TY - JOUR
T1 - Population studies on three Native Alaska population groups using STR loci
AU - Budowle, Bruce
AU - Chidambaram, Abirami
AU - Strickland, Leanne
AU - Beheim, Chris W.
AU - Taft, George M.
AU - Chakraborty, Ranajit
N1 - Funding Information:
This research was supported in part by a grants from the National Institute of Justice, Forensic DNA Laboratory Improvement Program and the Bureau of Justice Assistance, State Identification Systems Program.
PY - 2002/9/10
Y1 - 2002/9/10
N2 - Allele distributions for 13 short tandem repeat (STR) loci D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, TH01, TPOX, CSF1PO and D16S539 were determined for three Native Alaskan population groups - Athabaskans, Inupiats, and Yupiks. Although genetic diversity is lower in the Native Alaskan populations compared with Caucasians and Africans, almost all loci are highly polymorphic in all three Native Alaskan groups. There was little evidence for departures from Hardy-Weinberg expectations (HWE) in any of the populations. Only two examples of detectable departures from HWE out of 39 locus-population tests performed were observed based on the exact test (Yupik, D8S1179, P=0.030; Yupik, D5S818, P=0.016). The FST estimate overall 13 STR loci is 0.0309 for the Native Alaskan populations. Based on a genetic distance measure, Athabaskans are more closely related to Apaches and Navajos (all of the same linguistic group) than the other Native Alaskan groups. The FST estimate for Athabaskans, Apaches and Navajos is 0.0180 and for Inupiats and Yupiks is 0.0167. The allele frequency data can be used for estimating DNA profile frequencies for Native Americans residing in Alaska.
AB - Allele distributions for 13 short tandem repeat (STR) loci D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, TH01, TPOX, CSF1PO and D16S539 were determined for three Native Alaskan population groups - Athabaskans, Inupiats, and Yupiks. Although genetic diversity is lower in the Native Alaskan populations compared with Caucasians and Africans, almost all loci are highly polymorphic in all three Native Alaskan groups. There was little evidence for departures from Hardy-Weinberg expectations (HWE) in any of the populations. Only two examples of detectable departures from HWE out of 39 locus-population tests performed were observed based on the exact test (Yupik, D8S1179, P=0.030; Yupik, D5S818, P=0.016). The FST estimate overall 13 STR loci is 0.0309 for the Native Alaskan populations. Based on a genetic distance measure, Athabaskans are more closely related to Apaches and Navajos (all of the same linguistic group) than the other Native Alaskan groups. The FST estimate for Athabaskans, Apaches and Navajos is 0.0180 and for Inupiats and Yupiks is 0.0167. The allele frequency data can be used for estimating DNA profile frequencies for Native Americans residing in Alaska.
KW - Alaska native population
KW - Allele frequency
KW - AmpFlSTR Profiler Plus and AmpFlSTR Cofiler
KW - Athabaskan
KW - Eskimo
KW - Genetic profile
KW - Inupiat
KW - Population genetics
KW - Short tandem repeats (STRs)
KW - Yupik
UR - http://www.scopus.com/inward/record.url?scp=0037057114&partnerID=8YFLogxK
U2 - 10.1016/S0379-0738(02)00209-8
DO - 10.1016/S0379-0738(02)00209-8
M3 - Article
C2 - 12230997
AN - SCOPUS:0037057114
SN - 0379-0738
VL - 129
SP - 51
EP - 57
JO - Forensic Science International
JF - Forensic Science International
IS - 1
ER -