TY - JOUR
T1 - Population data of 21 non-CODIS STR loci in Han population of northern China
AU - Yuan, Li
AU - Ge, Jianye
AU - Lu, Di
AU - Yang, Xue
PY - 2012/7/1
Y1 - 2012/7/1
N2 - Allele frequencies and forensic statistics of 21 autosomal short tandem repeat loci (i.e., D6S474, D12ATA63, D22S1045, D10S1248, D1S1677, D11S4463, D1S1627, D3S4529, D2S441, D6S1017, D4S2408, D19S433, D17S1301, D1GATA113, D18S853, D20S482, D14S1434, D9S1122, D2S1776, D10S1435 and D5S2500) were estimated in Han population from northern China (n0220). Significant deviation from Hardy-Weinberg equilibrium was detected only for D22S1045. The observed heterozygosity, the expected heterozygosity, the discrimination power, the probability of paternity exclusion in trios, the probability of paternity exclusion in duos and the polymorphic information content ranged from 0.591 to 0.836, 0.594 to 0.830, 0.762 to 0.948, 0.341 to 0.659, 0.189 to 0.487 and 0.535 to 0.807, respectively. Triallelic patterns were observed at D19S433 and D10S1435. Mutations occurred at D22ATA63, D10S1248, D19S433 and D14S1434 loci with all single-step mutations. The expected mutation rates of these four loci are 0.0042 with 95% confidence interval [0.0001, 0.0232] in a total of 238 meioses. Our results show that these 21 non- CODIS STR loci are highly polymorphic and can be useful for human identification and kinship analysis in Northern Han population in China.
AB - Allele frequencies and forensic statistics of 21 autosomal short tandem repeat loci (i.e., D6S474, D12ATA63, D22S1045, D10S1248, D1S1677, D11S4463, D1S1627, D3S4529, D2S441, D6S1017, D4S2408, D19S433, D17S1301, D1GATA113, D18S853, D20S482, D14S1434, D9S1122, D2S1776, D10S1435 and D5S2500) were estimated in Han population from northern China (n0220). Significant deviation from Hardy-Weinberg equilibrium was detected only for D22S1045. The observed heterozygosity, the expected heterozygosity, the discrimination power, the probability of paternity exclusion in trios, the probability of paternity exclusion in duos and the polymorphic information content ranged from 0.591 to 0.836, 0.594 to 0.830, 0.762 to 0.948, 0.341 to 0.659, 0.189 to 0.487 and 0.535 to 0.807, respectively. Triallelic patterns were observed at D19S433 and D10S1435. Mutations occurred at D22ATA63, D10S1248, D19S433 and D14S1434 loci with all single-step mutations. The expected mutation rates of these four loci are 0.0042 with 95% confidence interval [0.0001, 0.0232] in a total of 238 meioses. Our results show that these 21 non- CODIS STR loci are highly polymorphic and can be useful for human identification and kinship analysis in Northern Han population in China.
KW - Genotyping
KW - Han population
KW - Linkage
KW - Linkage Disequilibrium
KW - Non-CODIS
KW - Population data
KW - Short tandem repeats
UR - http://www.scopus.com/inward/record.url?scp=84864059262&partnerID=8YFLogxK
U2 - 10.1007/s00414-011-0664-4
DO - 10.1007/s00414-011-0664-4
M3 - Article
C2 - 22245836
AN - SCOPUS:84864059262
SN - 0937-9827
VL - 126
SP - 659
EP - 664
JO - International Journal of Legal Medicine
JF - International Journal of Legal Medicine
IS - 4
ER -