Polyketide biosynthesis beyond the type I, II, and III polyketide synthase paradigms: A progress report

Ben Shen, Yi Qiang Cheng, Steven D. Christenson, Hui Jiang, Jianhua Ju, Hyung Jin Kwon, Si Kyu Lim, Wen Liu, Koichi Nonaka, Jeong Woo Seo, Wyatt C. Smith, Scott Standage, Gong Li Tang, Steven Van Lanen, Jian Zhang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

6 Scopus citations

Abstract

The archetypical polyketide synthases (PKSs), known as type I, II, and III PKSs, have accounted for the vast structural diversities embodied by polyketide natural products, but recent progress in polyketide biosynthesis clearly suggests much greater diversity for PKS mechanism and structure. We have previously argued the emergence of novel PKSs and cautioned the oversimplification of polyketide biosynthesis according to the type I, II, and III PKS paradigms on the basis of our studies on the biosynthesis of the enediynes, the macrotetrolides, and leinamycin. We present here a brief progress report on our current effort to mechanistically characterize these novel PKSs.

Original languageEnglish
Title of host publicationPolyketides Biosynthesis, Biological Activity, and Genetic Engineering
EditorsAgnes Rimando, Scott Baerson
Pages154-166
Number of pages13
StatePublished - 2007

Publication series

NameACS Symposium Series
Volume955
ISSN (Print)0097-6156

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