Plasticity of heart rate signalling and complexity with exercise training in obese individuals with and without type 2 diabetes

J. A. Kanaley, Styliani Goulopoulou, R. M. Franklin, T. Baynard, M. E. Holmstrup, R. Carhart, R. S. Weinstock, B. Fernhall

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19 Citations (Scopus)

Abstract

Objective:To examine the responsiveness of cardiac autonomic function and baroreflex sensitivity (BRS) to exercise training in obese individuals without (OB) and with type 2 diabetes (ObT2D).Design:Subjects were tested in the supine position and in response to a sympathetic challenge before and after a 16-week aerobic training program. All testing was conducted in the morning following a 12-h fast.Subjects:A total of 34 OB and 22 ObT2D men and women (40-60 years of age) were studied.Measurements:Heart rate variability (HRV) was measured at rest via continuous ECG (spectral analysis with the autoregressive approach) and in response to upright tilt. The dynamics of heart rate complexity were analyzed with sample entropy and Lempel-Ziv entropy, and BRS was determined via the sequence technique. Subjects were aerobically trained 4 times per week for 30-45 min for 16 weeks.Results:Resting HR decreased and total power (lnTP, ms 2) of HRV increased in response to exercise training (P0.05). High frequency power (lnHF) increased in OB subjects but not in OBT2D, and no changes occurred in ln low frequency/HF power with training. Upright tilt decreased lnTP and lnHF and increased LF/HF (P0.01) but there were no group differences in the magnitude of these changes nor were they altered with training in either group. Tilt also decreased complexity (sample entropy and Lempel-Ziv entropy; P0.001), but there was no group or training effect on complexity. BRS decreased with upright tilt (P0.01) but did not change with training. Compared to OB subjects the ObT2D had less tilt-induced changes in BRS.Conclusion:Exercise training improved HRV and parasympathetic modulation (lnHF) in OB subjects but not in ObT2D, indicating plasticity in the autonomic nervous system in response to this weight-neutral exercise program only in the absence of diabetes. HR complexity and BRS were not altered by 16 weeks of training in either OB or ObT2D individuals.

Original languageEnglish
Pages (from-to)1198-1206
Number of pages9
JournalInternational Journal of Obesity
Volume33
Issue number10
DOIs
StatePublished - 1 Oct 2009

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Baroreflex
Type 2 Diabetes Mellitus
Entropy
Heart Rate
Exercise
Supine Position
Autonomic Nervous System
Electrocardiography
Education
Weights and Measures

Keywords

  • Autonomic nervous system
  • HRV
  • Insulin resistance
  • Physical activity
  • R-R variation; upright tilt

Cite this

Kanaley, J. A. ; Goulopoulou, Styliani ; Franklin, R. M. ; Baynard, T. ; Holmstrup, M. E. ; Carhart, R. ; Weinstock, R. S. ; Fernhall, B. / Plasticity of heart rate signalling and complexity with exercise training in obese individuals with and without type 2 diabetes. In: International Journal of Obesity. 2009 ; Vol. 33, No. 10. pp. 1198-1206.
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abstract = "Objective:To examine the responsiveness of cardiac autonomic function and baroreflex sensitivity (BRS) to exercise training in obese individuals without (OB) and with type 2 diabetes (ObT2D).Design:Subjects were tested in the supine position and in response to a sympathetic challenge before and after a 16-week aerobic training program. All testing was conducted in the morning following a 12-h fast.Subjects:A total of 34 OB and 22 ObT2D men and women (40-60 years of age) were studied.Measurements:Heart rate variability (HRV) was measured at rest via continuous ECG (spectral analysis with the autoregressive approach) and in response to upright tilt. The dynamics of heart rate complexity were analyzed with sample entropy and Lempel-Ziv entropy, and BRS was determined via the sequence technique. Subjects were aerobically trained 4 times per week for 30-45 min for 16 weeks.Results:Resting HR decreased and total power (lnTP, ms 2) of HRV increased in response to exercise training (P0.05). High frequency power (lnHF) increased in OB subjects but not in OBT2D, and no changes occurred in ln low frequency/HF power with training. Upright tilt decreased lnTP and lnHF and increased LF/HF (P0.01) but there were no group differences in the magnitude of these changes nor were they altered with training in either group. Tilt also decreased complexity (sample entropy and Lempel-Ziv entropy; P0.001), but there was no group or training effect on complexity. BRS decreased with upright tilt (P0.01) but did not change with training. Compared to OB subjects the ObT2D had less tilt-induced changes in BRS.Conclusion:Exercise training improved HRV and parasympathetic modulation (lnHF) in OB subjects but not in ObT2D, indicating plasticity in the autonomic nervous system in response to this weight-neutral exercise program only in the absence of diabetes. HR complexity and BRS were not altered by 16 weeks of training in either OB or ObT2D individuals.",
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Plasticity of heart rate signalling and complexity with exercise training in obese individuals with and without type 2 diabetes. / Kanaley, J. A.; Goulopoulou, Styliani; Franklin, R. M.; Baynard, T.; Holmstrup, M. E.; Carhart, R.; Weinstock, R. S.; Fernhall, B.

In: International Journal of Obesity, Vol. 33, No. 10, 01.10.2009, p. 1198-1206.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Plasticity of heart rate signalling and complexity with exercise training in obese individuals with and without type 2 diabetes

AU - Kanaley, J. A.

AU - Goulopoulou, Styliani

AU - Franklin, R. M.

AU - Baynard, T.

AU - Holmstrup, M. E.

AU - Carhart, R.

AU - Weinstock, R. S.

AU - Fernhall, B.

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N2 - Objective:To examine the responsiveness of cardiac autonomic function and baroreflex sensitivity (BRS) to exercise training in obese individuals without (OB) and with type 2 diabetes (ObT2D).Design:Subjects were tested in the supine position and in response to a sympathetic challenge before and after a 16-week aerobic training program. All testing was conducted in the morning following a 12-h fast.Subjects:A total of 34 OB and 22 ObT2D men and women (40-60 years of age) were studied.Measurements:Heart rate variability (HRV) was measured at rest via continuous ECG (spectral analysis with the autoregressive approach) and in response to upright tilt. The dynamics of heart rate complexity were analyzed with sample entropy and Lempel-Ziv entropy, and BRS was determined via the sequence technique. Subjects were aerobically trained 4 times per week for 30-45 min for 16 weeks.Results:Resting HR decreased and total power (lnTP, ms 2) of HRV increased in response to exercise training (P0.05). High frequency power (lnHF) increased in OB subjects but not in OBT2D, and no changes occurred in ln low frequency/HF power with training. Upright tilt decreased lnTP and lnHF and increased LF/HF (P0.01) but there were no group differences in the magnitude of these changes nor were they altered with training in either group. Tilt also decreased complexity (sample entropy and Lempel-Ziv entropy; P0.001), but there was no group or training effect on complexity. BRS decreased with upright tilt (P0.01) but did not change with training. Compared to OB subjects the ObT2D had less tilt-induced changes in BRS.Conclusion:Exercise training improved HRV and parasympathetic modulation (lnHF) in OB subjects but not in ObT2D, indicating plasticity in the autonomic nervous system in response to this weight-neutral exercise program only in the absence of diabetes. HR complexity and BRS were not altered by 16 weeks of training in either OB or ObT2D individuals.

AB - Objective:To examine the responsiveness of cardiac autonomic function and baroreflex sensitivity (BRS) to exercise training in obese individuals without (OB) and with type 2 diabetes (ObT2D).Design:Subjects were tested in the supine position and in response to a sympathetic challenge before and after a 16-week aerobic training program. All testing was conducted in the morning following a 12-h fast.Subjects:A total of 34 OB and 22 ObT2D men and women (40-60 years of age) were studied.Measurements:Heart rate variability (HRV) was measured at rest via continuous ECG (spectral analysis with the autoregressive approach) and in response to upright tilt. The dynamics of heart rate complexity were analyzed with sample entropy and Lempel-Ziv entropy, and BRS was determined via the sequence technique. Subjects were aerobically trained 4 times per week for 30-45 min for 16 weeks.Results:Resting HR decreased and total power (lnTP, ms 2) of HRV increased in response to exercise training (P0.05). High frequency power (lnHF) increased in OB subjects but not in OBT2D, and no changes occurred in ln low frequency/HF power with training. Upright tilt decreased lnTP and lnHF and increased LF/HF (P0.01) but there were no group differences in the magnitude of these changes nor were they altered with training in either group. Tilt also decreased complexity (sample entropy and Lempel-Ziv entropy; P0.001), but there was no group or training effect on complexity. BRS decreased with upright tilt (P0.01) but did not change with training. Compared to OB subjects the ObT2D had less tilt-induced changes in BRS.Conclusion:Exercise training improved HRV and parasympathetic modulation (lnHF) in OB subjects but not in ObT2D, indicating plasticity in the autonomic nervous system in response to this weight-neutral exercise program only in the absence of diabetes. HR complexity and BRS were not altered by 16 weeks of training in either OB or ObT2D individuals.

KW - Autonomic nervous system

KW - HRV

KW - Insulin resistance

KW - Physical activity

KW - R-R variation; upright tilt

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