Plasma lipids and cholesterol esterification in Alzheimer's disease

Janice Knebl; Peggy DeFazio; Michael B. Clearfield; Laurie Little; Walter J. McConathy; Ruth Mc Pherson; Andras G. Lacko

doi:10.1016/0047-6374(94)90039-6

Plasma lipids and cholesterol esterification in Alzheimer's disease

Janice Knebl, Peggy DeFazio, Michael B. Clearfield, Laurie Little, Walter J. McConathy, Ruth Mc Pherson, Andras G. Lacko

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Abstract

Eight patients and eight age matched controls were recruited to study parameters related to plasma lipoprotein metabolism in Alzheimer's disease based on previous studies in Down's syndrome (A.G. Lacko et al., Clin. Chim. Acta, 132 (1983) 133). The fractional rate of cholesterol esterification (% cholesterol esterifed per hour) was 16% lower in the patient group compared with controls. Correlational analyses of lecithin/cholesterol acyltransferase (LCAT) activity and plasma lipids revealed additional differences between the Alzheimer's patients and control subjects. These data are strikingly similar to those obtained earlier with Down's syndrome patients. These data, combined with analyses of cholesteryl ester transfer protein (CETP) levels, suggest that reverse cholesterol transport in general and CETP activity in particular may be altered in Alzheimer's disease.

Original language	English
Pages (from-to)	69-77
Number of pages	9
Journal	Mechanisms of Ageing and Development
Volume	73
Issue number	1
DOIs	https://doi.org/10.1016/0047-6374(94)90039-6
State	Published - Jan 1994

Keywords

Alzheimer's disease
Cholesterol esterification
Down's syndrome
LCAT
Lipoproteins

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10.1016/0047-6374(94)90039-6

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title = "Plasma lipids and cholesterol esterification in Alzheimer's disease",

abstract = "Eight patients and eight age matched controls were recruited to study parameters related to plasma lipoprotein metabolism in Alzheimer's disease based on previous studies in Down's syndrome (A.G. Lacko et al., Clin. Chim. Acta, 132 (1983) 133). The fractional rate of cholesterol esterification (% cholesterol esterifed per hour) was 16% lower in the patient group compared with controls. Correlational analyses of lecithin/cholesterol acyltransferase (LCAT) activity and plasma lipids revealed additional differences between the Alzheimer's patients and control subjects. These data are strikingly similar to those obtained earlier with Down's syndrome patients. These data, combined with analyses of cholesteryl ester transfer protein (CETP) levels, suggest that reverse cholesterol transport in general and CETP activity in particular may be altered in Alzheimer's disease.",

keywords = "Alzheimer's disease, Cholesterol esterification, Down's syndrome, LCAT, Lipoproteins",

author = "Janice Knebl and Peggy DeFazio and Clearfield, {Michael B.} and Laurie Little and McConathy, {Walter J.} and {Mc Pherson}, Ruth and Lacko, {Andras G.}",

note = "Funding Information: Support for this study was provided by the Texas Institute for Education and Research on Aging (TIREA) and the Me&cal Service, Research and Development fund of the Department of Medlcme/UNTHSC Jan Sharp provided excellent secretarial assistance",

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doi = "10.1016/0047-6374(94)90039-6",

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AU - Knebl, Janice

AU - DeFazio, Peggy

AU - Clearfield, Michael B.

AU - Little, Laurie

AU - McConathy, Walter J.

AU - Mc Pherson, Ruth

AU - Lacko, Andras G.

N1 - Funding Information: Support for this study was provided by the Texas Institute for Education and Research on Aging (TIREA) and the Me&cal Service, Research and Development fund of the Department of Medlcme/UNTHSC Jan Sharp provided excellent secretarial assistance

PY - 1994/1

Y1 - 1994/1

N2 - Eight patients and eight age matched controls were recruited to study parameters related to plasma lipoprotein metabolism in Alzheimer's disease based on previous studies in Down's syndrome (A.G. Lacko et al., Clin. Chim. Acta, 132 (1983) 133). The fractional rate of cholesterol esterification (% cholesterol esterifed per hour) was 16% lower in the patient group compared with controls. Correlational analyses of lecithin/cholesterol acyltransferase (LCAT) activity and plasma lipids revealed additional differences between the Alzheimer's patients and control subjects. These data are strikingly similar to those obtained earlier with Down's syndrome patients. These data, combined with analyses of cholesteryl ester transfer protein (CETP) levels, suggest that reverse cholesterol transport in general and CETP activity in particular may be altered in Alzheimer's disease.

AB - Eight patients and eight age matched controls were recruited to study parameters related to plasma lipoprotein metabolism in Alzheimer's disease based on previous studies in Down's syndrome (A.G. Lacko et al., Clin. Chim. Acta, 132 (1983) 133). The fractional rate of cholesterol esterification (% cholesterol esterifed per hour) was 16% lower in the patient group compared with controls. Correlational analyses of lecithin/cholesterol acyltransferase (LCAT) activity and plasma lipids revealed additional differences between the Alzheimer's patients and control subjects. These data are strikingly similar to those obtained earlier with Down's syndrome patients. These data, combined with analyses of cholesteryl ester transfer protein (CETP) levels, suggest that reverse cholesterol transport in general and CETP activity in particular may be altered in Alzheimer's disease.

KW - Alzheimer's disease

KW - Cholesterol esterification

KW - Down's syndrome

KW - LCAT

KW - Lipoproteins

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Plasma lipids and cholesterol esterification in Alzheimer's disease

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Keywords

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