Plasma lipids and cholesterol esterification in Alzheimer's disease

Janice Knebl; Peggy DeFazio; Michael B. Clearfield; Laurie Little; Walter J. McConathy; Ruth Mc Pherson; Andras G. Lacko

doi:10.1016/0047-6374(94)90039-6

Plasma lipids and cholesterol esterification in Alzheimer's disease

Janice Knebl, Peggy DeFazio, Michael B. Clearfield, Laurie Little, Walter J. McConathy, Ruth Mc Pherson, Andras G. Lacko

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Eight patients and eight age matched controls were recruited to study parameters related to plasma lipoprotein metabolism in Alzheimer's disease based on previous studies in Down's syndrome (A.G. Lacko et al., Clin. Chim. Acta, 132 (1983) 133). The fractional rate of cholesterol esterification (% cholesterol esterifed per hour) was 16% lower in the patient group compared with controls. Correlational analyses of lecithin/cholesterol acyltransferase (LCAT) activity and plasma lipids revealed additional differences between the Alzheimer's patients and control subjects. These data are strikingly similar to those obtained earlier with Down's syndrome patients. These data, combined with analyses of cholesteryl ester transfer protein (CETP) levels, suggest that reverse cholesterol transport in general and CETP activity in particular may be altered in Alzheimer's disease.

Original language	English
Pages (from-to)	69-77
Number of pages	9
Journal	Mechanisms of Ageing and Development
Volume	73
Issue number	1
DOIs	https://doi.org/10.1016/0047-6374(94)90039-6
State	Published - Jan 1994

Keywords

Alzheimer's disease
Cholesterol esterification
Down's syndrome
LCAT
Lipoproteins

Access to Document

10.1016/0047-6374(94)90039-6

Link to publication in Scopus

Fingerprint Dive into the research topics of 'Plasma lipids and cholesterol esterification in Alzheimer's disease'. Together they form a unique fingerprint.

Cite this

@article{b96bc157c1b649f3b825568c78138d27,

title = "Plasma lipids and cholesterol esterification in Alzheimer's disease",

abstract = "Eight patients and eight age matched controls were recruited to study parameters related to plasma lipoprotein metabolism in Alzheimer's disease based on previous studies in Down's syndrome (A.G. Lacko et al., Clin. Chim. Acta, 132 (1983) 133). The fractional rate of cholesterol esterification (% cholesterol esterifed per hour) was 16% lower in the patient group compared with controls. Correlational analyses of lecithin/cholesterol acyltransferase (LCAT) activity and plasma lipids revealed additional differences between the Alzheimer's patients and control subjects. These data are strikingly similar to those obtained earlier with Down's syndrome patients. These data, combined with analyses of cholesteryl ester transfer protein (CETP) levels, suggest that reverse cholesterol transport in general and CETP activity in particular may be altered in Alzheimer's disease.",

keywords = "Alzheimer's disease, Cholesterol esterification, Down's syndrome, LCAT, Lipoproteins",

author = "Janice Knebl and Peggy DeFazio and Clearfield, {Michael B.} and Laurie Little and McConathy, {Walter J.} and {Mc Pherson}, Ruth and Lacko, {Andras G.}",

year = "1994",

month = jan,

doi = "10.1016/0047-6374(94)90039-6",

language = "English",

volume = "73",

pages = "69--77",

journal = "Mechanisms of Ageing and Development",

issn = "0047-6374",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Plasma lipids and cholesterol esterification in Alzheimer's disease

AU - Knebl, Janice

AU - DeFazio, Peggy

AU - Clearfield, Michael B.

AU - Little, Laurie

AU - McConathy, Walter J.

AU - Mc Pherson, Ruth

AU - Lacko, Andras G.

PY - 1994/1

Y1 - 1994/1

N2 - Eight patients and eight age matched controls were recruited to study parameters related to plasma lipoprotein metabolism in Alzheimer's disease based on previous studies in Down's syndrome (A.G. Lacko et al., Clin. Chim. Acta, 132 (1983) 133). The fractional rate of cholesterol esterification (% cholesterol esterifed per hour) was 16% lower in the patient group compared with controls. Correlational analyses of lecithin/cholesterol acyltransferase (LCAT) activity and plasma lipids revealed additional differences between the Alzheimer's patients and control subjects. These data are strikingly similar to those obtained earlier with Down's syndrome patients. These data, combined with analyses of cholesteryl ester transfer protein (CETP) levels, suggest that reverse cholesterol transport in general and CETP activity in particular may be altered in Alzheimer's disease.

AB - Eight patients and eight age matched controls were recruited to study parameters related to plasma lipoprotein metabolism in Alzheimer's disease based on previous studies in Down's syndrome (A.G. Lacko et al., Clin. Chim. Acta, 132 (1983) 133). The fractional rate of cholesterol esterification (% cholesterol esterifed per hour) was 16% lower in the patient group compared with controls. Correlational analyses of lecithin/cholesterol acyltransferase (LCAT) activity and plasma lipids revealed additional differences between the Alzheimer's patients and control subjects. These data are strikingly similar to those obtained earlier with Down's syndrome patients. These data, combined with analyses of cholesteryl ester transfer protein (CETP) levels, suggest that reverse cholesterol transport in general and CETP activity in particular may be altered in Alzheimer's disease.

KW - Alzheimer's disease

KW - Cholesterol esterification

KW - Down's syndrome

KW - LCAT

KW - Lipoproteins

UR - http://www.scopus.com/inward/record.url?scp=0028204944&partnerID=8YFLogxK

U2 - 10.1016/0047-6374(94)90039-6

DO - 10.1016/0047-6374(94)90039-6

M3 - Article

C2 - 8028399

AN - SCOPUS:0028204944

VL - 73

SP - 69

EP - 77

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

SN - 0047-6374

IS - 1

ER -