Abstract
Haloperidol (HL) and reduced haloperidol (RH) plasma concentrations were measured in geriatric patients (n = 45) and schizophrenic patients (n = 8). In the elderly patients, HL doses were 1-4 mg/day while only 2 mg/day was used in the schizophrenics. At HL 2 mg/day dose in both age groups, mean plasma HL levels were approximately twice as high in the elderly patients compared to the schizophrenics (1.39 ± 0.82 vs. 0.56 ± 0.23 ng/ml, p < 0.02). RH plasma concentrations were almost 5 times greater in the elderly patients (0.54 ± 0.35 vs. 0.09 ± 0.05 ng/ml, p < 0.0001). These results suggest that HL plasma concentrations in the elderly are greater than in adult schizophrenic patients treated with similiar HL doses.
Original language | English |
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Pages (from-to) | 12-16 |
Number of pages | 5 |
Journal | Neuropsychobiology |
Volume | 33 |
Issue number | 1 |
DOIs | |
State | Published - 1996 |
Keywords
- Geriatrics
- Haloperidol
- Plasma levels
- Reduced haloperidol