Plasma haloperidol and reduced haloperidol concentrations in a geriatric population

Wen Ho Chang, Michael W. Jann, Teh Soon Chiang, Hsin Nan Lin, Wei Herng Hu, Ching Paio Chien

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Haloperidol (HL) and reduced haloperidol (RH) plasma concentrations were measured in geriatric patients (n = 45) and schizophrenic patients (n = 8). In the elderly patients, HL doses were 1-4 mg/day while only 2 mg/day was used in the schizophrenics. At HL 2 mg/day dose in both age groups, mean plasma HL levels were approximately twice as high in the elderly patients compared to the schizophrenics (1.39 ± 0.82 vs. 0.56 ± 0.23 ng/ml, p < 0.02). RH plasma concentrations were almost 5 times greater in the elderly patients (0.54 ± 0.35 vs. 0.09 ± 0.05 ng/ml, p < 0.0001). These results suggest that HL plasma concentrations in the elderly are greater than in adult schizophrenic patients treated with similiar HL doses.

Original languageEnglish
Pages (from-to)12-16
Number of pages5
JournalNeuropsychobiology
Volume33
Issue number1
DOIs
StatePublished - 1 Jan 1996

Keywords

  • Geriatrics
  • Haloperidol
  • Plasma levels
  • Reduced haloperidol

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