Plasma cystatin C and high-density lipoprotein are important biomarkers of Alzheimer's disease and vascular dementia: A cross-sectional study

Rui Wang, Zhaoyu Chen, Yongmei Fu, Xiaobo Wei, Jinchi Liao, Xu Liu, Bingjun He, Yunqi Xu, Jing Zou, Xiaoyan Yang, Ruihui Weng, Sheng Tan, Christopher McElroy, Kunlin Jin, Qing Wang

Research output: Contribution to journalArticle

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Abstract

Objectives: Cystatin C (Cys C) and high-density lipoprotein (HDL) play critical roles in neurodegenerative diseases, such as dementia, Alzheimer's disease (AD) and vascular dementia (VaD). However, whether they can be used as reliable biomarkers to distinguish patients with dementia from healthy subjects and to determine disease severity remain largely unknown. Methods: We conducted a cross-sectional study to determine plasma Cys C and HDL levels of 88 patients with dementia (43 AD patients, 45 VaD patients) and 45 healthy age-matched controls. The severity of dementia was determined based on the Schwab and England Activities of Daily Living (ADL) Scale, the Mini-mental State Examination (MMSE), the Global Deterioration Scale (GDS), the Lawton Instrumental ADL (IADL) Scale, and the Hachinski Ischemia Scale (Hachinski). Receiver operating characteristic (ROC) curves were calculated to determine the diagnostic accuracy of Cys C and HDL levels in distinguishing patients with dementia from healthy subjects. Results: We found that plasma Cys C levels were higher, but HDL levels were lower in AD and VaD patients respectively, compared to healthy control subjects. Yet, Cys C levels were highest among patients with VaD. Interestingly, plasma Cys C levels were significantly correlated with IADL Scale scores. In addition, the ROC curves for Cys C (area under the curve, AUC 0.816 for AD, AUC 0.841 for VaD) and HDL (AUC 0.800 for AD, AUC 0.731 for VaD) exhibited potential diagnostic value in distinguishing AD/VaD patients from healthy subjects. While the ROC curve for the combination of Cys C and HDL (AUC 0.873 for AD, AUC 0.897 for VaD) showed higher diagnostic accuracy in distinguishing AD/VaD patients from healthy subjects than the separate curves for each parameter. Conclusions: Our findings suggest that the inflammatory mediators Cys C and HDL may play important roles in the pathogenesis of dementia, and plasma Cys C and HDL levels may be useful screening tools for differentiating AD/VaD patients from healthy subjects.

Original languageEnglish
Article number26
JournalFrontiers in Aging Neuroscience
Volume9
Issue numberFEB
DOIs
StatePublished - 7 Feb 2017

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Cystatin C
Vascular Dementia
HDL Lipoproteins
Alzheimer Disease
Cross-Sectional Studies
Biomarkers
Area Under Curve
Dementia
Healthy Volunteers
Activities of Daily Living
ROC Curve
England
Neurodegenerative Diseases
Ischemia

Keywords

  • Alzheimer's disease
  • Cystatin C
  • Dementia
  • High-density lipoprotein
  • Vascular dementia

Cite this

Wang, Rui ; Chen, Zhaoyu ; Fu, Yongmei ; Wei, Xiaobo ; Liao, Jinchi ; Liu, Xu ; He, Bingjun ; Xu, Yunqi ; Zou, Jing ; Yang, Xiaoyan ; Weng, Ruihui ; Tan, Sheng ; McElroy, Christopher ; Jin, Kunlin ; Wang, Qing. / Plasma cystatin C and high-density lipoprotein are important biomarkers of Alzheimer's disease and vascular dementia : A cross-sectional study. In: Frontiers in Aging Neuroscience. 2017 ; Vol. 9, No. FEB.
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abstract = "Objectives: Cystatin C (Cys C) and high-density lipoprotein (HDL) play critical roles in neurodegenerative diseases, such as dementia, Alzheimer's disease (AD) and vascular dementia (VaD). However, whether they can be used as reliable biomarkers to distinguish patients with dementia from healthy subjects and to determine disease severity remain largely unknown. Methods: We conducted a cross-sectional study to determine plasma Cys C and HDL levels of 88 patients with dementia (43 AD patients, 45 VaD patients) and 45 healthy age-matched controls. The severity of dementia was determined based on the Schwab and England Activities of Daily Living (ADL) Scale, the Mini-mental State Examination (MMSE), the Global Deterioration Scale (GDS), the Lawton Instrumental ADL (IADL) Scale, and the Hachinski Ischemia Scale (Hachinski). Receiver operating characteristic (ROC) curves were calculated to determine the diagnostic accuracy of Cys C and HDL levels in distinguishing patients with dementia from healthy subjects. Results: We found that plasma Cys C levels were higher, but HDL levels were lower in AD and VaD patients respectively, compared to healthy control subjects. Yet, Cys C levels were highest among patients with VaD. Interestingly, plasma Cys C levels were significantly correlated with IADL Scale scores. In addition, the ROC curves for Cys C (area under the curve, AUC 0.816 for AD, AUC 0.841 for VaD) and HDL (AUC 0.800 for AD, AUC 0.731 for VaD) exhibited potential diagnostic value in distinguishing AD/VaD patients from healthy subjects. While the ROC curve for the combination of Cys C and HDL (AUC 0.873 for AD, AUC 0.897 for VaD) showed higher diagnostic accuracy in distinguishing AD/VaD patients from healthy subjects than the separate curves for each parameter. Conclusions: Our findings suggest that the inflammatory mediators Cys C and HDL may play important roles in the pathogenesis of dementia, and plasma Cys C and HDL levels may be useful screening tools for differentiating AD/VaD patients from healthy subjects.",
keywords = "Alzheimer's disease, Cystatin C, Dementia, High-density lipoprotein, Vascular dementia",
author = "Rui Wang and Zhaoyu Chen and Yongmei Fu and Xiaobo Wei and Jinchi Liao and Xu Liu and Bingjun He and Yunqi Xu and Jing Zou and Xiaoyan Yang and Ruihui Weng and Sheng Tan and Christopher McElroy and Kunlin Jin and Qing Wang",
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Wang, R, Chen, Z, Fu, Y, Wei, X, Liao, J, Liu, X, He, B, Xu, Y, Zou, J, Yang, X, Weng, R, Tan, S, McElroy, C, Jin, K & Wang, Q 2017, 'Plasma cystatin C and high-density lipoprotein are important biomarkers of Alzheimer's disease and vascular dementia: A cross-sectional study', Frontiers in Aging Neuroscience, vol. 9, no. FEB, 26. https://doi.org/10.3389/fnagi.2017.00026

Plasma cystatin C and high-density lipoprotein are important biomarkers of Alzheimer's disease and vascular dementia : A cross-sectional study. / Wang, Rui; Chen, Zhaoyu; Fu, Yongmei; Wei, Xiaobo; Liao, Jinchi; Liu, Xu; He, Bingjun; Xu, Yunqi; Zou, Jing; Yang, Xiaoyan; Weng, Ruihui; Tan, Sheng; McElroy, Christopher; Jin, Kunlin; Wang, Qing.

In: Frontiers in Aging Neuroscience, Vol. 9, No. FEB, 26, 07.02.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Plasma cystatin C and high-density lipoprotein are important biomarkers of Alzheimer's disease and vascular dementia

T2 - A cross-sectional study

AU - Wang, Rui

AU - Chen, Zhaoyu

AU - Fu, Yongmei

AU - Wei, Xiaobo

AU - Liao, Jinchi

AU - Liu, Xu

AU - He, Bingjun

AU - Xu, Yunqi

AU - Zou, Jing

AU - Yang, Xiaoyan

AU - Weng, Ruihui

AU - Tan, Sheng

AU - McElroy, Christopher

AU - Jin, Kunlin

AU - Wang, Qing

PY - 2017/2/7

Y1 - 2017/2/7

N2 - Objectives: Cystatin C (Cys C) and high-density lipoprotein (HDL) play critical roles in neurodegenerative diseases, such as dementia, Alzheimer's disease (AD) and vascular dementia (VaD). However, whether they can be used as reliable biomarkers to distinguish patients with dementia from healthy subjects and to determine disease severity remain largely unknown. Methods: We conducted a cross-sectional study to determine plasma Cys C and HDL levels of 88 patients with dementia (43 AD patients, 45 VaD patients) and 45 healthy age-matched controls. The severity of dementia was determined based on the Schwab and England Activities of Daily Living (ADL) Scale, the Mini-mental State Examination (MMSE), the Global Deterioration Scale (GDS), the Lawton Instrumental ADL (IADL) Scale, and the Hachinski Ischemia Scale (Hachinski). Receiver operating characteristic (ROC) curves were calculated to determine the diagnostic accuracy of Cys C and HDL levels in distinguishing patients with dementia from healthy subjects. Results: We found that plasma Cys C levels were higher, but HDL levels were lower in AD and VaD patients respectively, compared to healthy control subjects. Yet, Cys C levels were highest among patients with VaD. Interestingly, plasma Cys C levels were significantly correlated with IADL Scale scores. In addition, the ROC curves for Cys C (area under the curve, AUC 0.816 for AD, AUC 0.841 for VaD) and HDL (AUC 0.800 for AD, AUC 0.731 for VaD) exhibited potential diagnostic value in distinguishing AD/VaD patients from healthy subjects. While the ROC curve for the combination of Cys C and HDL (AUC 0.873 for AD, AUC 0.897 for VaD) showed higher diagnostic accuracy in distinguishing AD/VaD patients from healthy subjects than the separate curves for each parameter. Conclusions: Our findings suggest that the inflammatory mediators Cys C and HDL may play important roles in the pathogenesis of dementia, and plasma Cys C and HDL levels may be useful screening tools for differentiating AD/VaD patients from healthy subjects.

AB - Objectives: Cystatin C (Cys C) and high-density lipoprotein (HDL) play critical roles in neurodegenerative diseases, such as dementia, Alzheimer's disease (AD) and vascular dementia (VaD). However, whether they can be used as reliable biomarkers to distinguish patients with dementia from healthy subjects and to determine disease severity remain largely unknown. Methods: We conducted a cross-sectional study to determine plasma Cys C and HDL levels of 88 patients with dementia (43 AD patients, 45 VaD patients) and 45 healthy age-matched controls. The severity of dementia was determined based on the Schwab and England Activities of Daily Living (ADL) Scale, the Mini-mental State Examination (MMSE), the Global Deterioration Scale (GDS), the Lawton Instrumental ADL (IADL) Scale, and the Hachinski Ischemia Scale (Hachinski). Receiver operating characteristic (ROC) curves were calculated to determine the diagnostic accuracy of Cys C and HDL levels in distinguishing patients with dementia from healthy subjects. Results: We found that plasma Cys C levels were higher, but HDL levels were lower in AD and VaD patients respectively, compared to healthy control subjects. Yet, Cys C levels were highest among patients with VaD. Interestingly, plasma Cys C levels were significantly correlated with IADL Scale scores. In addition, the ROC curves for Cys C (area under the curve, AUC 0.816 for AD, AUC 0.841 for VaD) and HDL (AUC 0.800 for AD, AUC 0.731 for VaD) exhibited potential diagnostic value in distinguishing AD/VaD patients from healthy subjects. While the ROC curve for the combination of Cys C and HDL (AUC 0.873 for AD, AUC 0.897 for VaD) showed higher diagnostic accuracy in distinguishing AD/VaD patients from healthy subjects than the separate curves for each parameter. Conclusions: Our findings suggest that the inflammatory mediators Cys C and HDL may play important roles in the pathogenesis of dementia, and plasma Cys C and HDL levels may be useful screening tools for differentiating AD/VaD patients from healthy subjects.

KW - Alzheimer's disease

KW - Cystatin C

KW - Dementia

KW - High-density lipoprotein

KW - Vascular dementia

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U2 - 10.3389/fnagi.2017.00026

DO - 10.3389/fnagi.2017.00026

M3 - Article

AN - SCOPUS:85014514622

VL - 9

JO - Frontiers in Aging Neuroscience

JF - Frontiers in Aging Neuroscience

SN - 1663-4365

IS - FEB

M1 - 26

ER -