Physiological derangement of the trauma patient

Henry Liu; Hong Yan; Seth Christian; Santiago Gomez; Frank Rosinia; Mingbing Chen; Juan Tan; Charles J. Fox; Alan David Kaye

doi:10.1007/978-1-4939-0909-4_3

Physiological derangement of the trauma patient

Henry Liu, Hong Yan, Seth Christian, Santiago Gomez, Frank Rosinia, Mingbing Chen, Juan Tan, Charles J. Fox, Alan David Kaye

School of Public Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

This chapter provides a systemic review of trauma-related physiological changes with tremendous updated information. The first part of this chapter analyzed the general physiological changes according to the following categories: (1) hemorrhage-related changes: trauma-related vicious cycle of hemorrhage, resuscitation, and coagulopathy; mechanisms of acute trauma coagulopathy (excessive activation of coagulation, hyperfibrinolysis, hypothermia, acidosis, increased capillary permeability, and platelet dysfunction). (2) Stress-related changes (behavioral activation). (3) Pain-related changes (ventilation and mental status). (4) Inflammatory changes and sepsis. (5) Metabolic changes. The second part of the chapter discussed three system-specific physiological changes after trauma: head trauma, chest and cardiac trauma, and trauma to abdominal and digestive system.

Original language	English
Title of host publication	Anesthesia for Trauma
Subtitle of host publication	New Evidence and New Challenges
Publisher	Springer New York
Pages	45-65
Number of pages	21
ISBN (Electronic)	9781493909094
ISBN (Print)	1493909088, 9781493909087
DOIs	https://doi.org/10.1007/978-1-4939-0909-4_3
State	Published - 1 Mar 2014

Keywords

Trauma physiology
acute traumatic coagulopathy
inflammatory response
sepsis
trauma related hyperfibrinolysis
trauma-induced vicious cycle

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10.1007/978-1-4939-0909-4_3

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abstract = "This chapter provides a systemic review of trauma-related physiological changes with tremendous updated information. The first part of this chapter analyzed the general physiological changes according to the following categories: (1) hemorrhage-related changes: trauma-related vicious cycle of hemorrhage, resuscitation, and coagulopathy; mechanisms of acute trauma coagulopathy (excessive activation of coagulation, hyperfibrinolysis, hypothermia, acidosis, increased capillary permeability, and platelet dysfunction). (2) Stress-related changes (behavioral activation). (3) Pain-related changes (ventilation and mental status). (4) Inflammatory changes and sepsis. (5) Metabolic changes. The second part of the chapter discussed three system-specific physiological changes after trauma: head trauma, chest and cardiac trauma, and trauma to abdominal and digestive system.",

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AU - Gomez, Santiago

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AU - Tan, Juan

AU - Fox, Charles J.

AU - Kaye, Alan David

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Physiological derangement of the trauma patient

Abstract

Keywords

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