Abstract
This chapter provides a systemic review of trauma-related physiological changes with tremendous updated information. The first part of this chapter analyzed the general physiological changes according to the following categories: (1) hemorrhage-related changes: trauma-related vicious cycle of hemorrhage, resuscitation, and coagulopathy; mechanisms of acute trauma coagulopathy (excessive activation of coagulation, hyperfibrinolysis, hypothermia, acidosis, increased capillary permeability, and platelet dysfunction). (2) Stress-related changes (behavioral activation). (3) Pain-related changes (ventilation and mental status). (4) Inflammatory changes and sepsis. (5) Metabolic changes. The second part of the chapter discussed three system-specific physiological changes after trauma: head trauma, chest and cardiac trauma, and trauma to abdominal and digestive system.
Original language | English |
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Title of host publication | Anesthesia for Trauma |
Subtitle of host publication | New Evidence and New Challenges |
Publisher | Springer New York |
Pages | 45-65 |
Number of pages | 21 |
ISBN (Electronic) | 9781493909094 |
ISBN (Print) | 1493909088, 9781493909087 |
DOIs | |
State | Published - 1 Mar 2014 |
Keywords
- Trauma physiology
- acute traumatic coagulopathy
- inflammatory response
- sepsis
- trauma related hyperfibrinolysis
- trauma-induced vicious cycle