Physical provocation of pubertal anabolic androgenic steroid exposed male rats elicits aggression towards females

Rebecca L. Cunningham; Marilyn Y. McGinnis

doi:10.1016/j.yhbeh.2006.05.002

Physical provocation of pubertal anabolic androgenic steroid exposed male rats elicits aggression towards females

Rebecca L. Cunningham, Marilyn Y. McGinnis

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A rat model used to evaluate and find whether anabolic androgen steroid (AAS) potentiated aggression towards female rat and conditions under which this occurs were investigated. An animal study to investigate AAS-nduced aggression towards female rats where male rats exposed to AAS during puberty were allowed to interact with females in three states of sexual receptivity. The goals of this experiment was to identify conditions under which AAS-treated males exhibit aggression towards females. This study demonstrates that perturbal exposure of males to chronic high doses of the AAS, testosterone, increases aggression towards females, and the enhanced aggression occurs only in response to provocation and in the presence of unreceptive females. Understanding and recognizing the predictive factors are expected to be useful in preventing AAS-induced aggression within the human population by the use of cognitive therapies.

Original language	English
Pages (from-to)	410-416
Number of pages	7
Journal	Hormones and Behavior
Volume	50
Issue number	3
DOIs	https://doi.org/10.1016/j.yhbeh.2006.05.002
State	Published - Sep 2006

Keywords

AAS
Adolescence
Dominance
Mounting behavior
Puberty
Sex behavior
Stanozolol
Tail pinch
Testosterone
Violence

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10.1016/j.yhbeh.2006.05.002

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@article{16458d51e9874de79d5d12f830aae393,

title = "Physical provocation of pubertal anabolic androgenic steroid exposed male rats elicits aggression towards females",

abstract = "A rat model used to evaluate and find whether anabolic androgen steroid (AAS) potentiated aggression towards female rat and conditions under which this occurs were investigated. An animal study to investigate AAS-nduced aggression towards female rats where male rats exposed to AAS during puberty were allowed to interact with females in three states of sexual receptivity. The goals of this experiment was to identify conditions under which AAS-treated males exhibit aggression towards females. This study demonstrates that perturbal exposure of males to chronic high doses of the AAS, testosterone, increases aggression towards females, and the enhanced aggression occurs only in response to provocation and in the presence of unreceptive females. Understanding and recognizing the predictive factors are expected to be useful in preventing AAS-induced aggression within the human population by the use of cognitive therapies.",

keywords = "AAS, Adolescence, Dominance, Mounting behavior, Puberty, Sex behavior, Stanozolol, Tail pinch, Testosterone, Violence",

author = "Cunningham, {Rebecca L.} and McGinnis, {Marilyn Y.}",

note = "Funding Information: We would like to thank Mr. Daniel Wesson for his excellent technical assistance and advice and Drs. Augustus R. Lumia and J. Thomas Cunningham for their helpful comments on the manuscript. This research was supported by NIH Grant DA 10886 to M.Y.M.",

year = "2006",

month = sep,

doi = "10.1016/j.yhbeh.2006.05.002",

language = "English",

volume = "50",

pages = "410--416",

journal = "Hormones and Behavior",

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publisher = "Academic Press Inc.",

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AU - Cunningham, Rebecca L.

AU - McGinnis, Marilyn Y.

N1 - Funding Information: We would like to thank Mr. Daniel Wesson for his excellent technical assistance and advice and Drs. Augustus R. Lumia and J. Thomas Cunningham for their helpful comments on the manuscript. This research was supported by NIH Grant DA 10886 to M.Y.M.

PY - 2006/9

Y1 - 2006/9

N2 - A rat model used to evaluate and find whether anabolic androgen steroid (AAS) potentiated aggression towards female rat and conditions under which this occurs were investigated. An animal study to investigate AAS-nduced aggression towards female rats where male rats exposed to AAS during puberty were allowed to interact with females in three states of sexual receptivity. The goals of this experiment was to identify conditions under which AAS-treated males exhibit aggression towards females. This study demonstrates that perturbal exposure of males to chronic high doses of the AAS, testosterone, increases aggression towards females, and the enhanced aggression occurs only in response to provocation and in the presence of unreceptive females. Understanding and recognizing the predictive factors are expected to be useful in preventing AAS-induced aggression within the human population by the use of cognitive therapies.

AB - A rat model used to evaluate and find whether anabolic androgen steroid (AAS) potentiated aggression towards female rat and conditions under which this occurs were investigated. An animal study to investigate AAS-nduced aggression towards female rats where male rats exposed to AAS during puberty were allowed to interact with females in three states of sexual receptivity. The goals of this experiment was to identify conditions under which AAS-treated males exhibit aggression towards females. This study demonstrates that perturbal exposure of males to chronic high doses of the AAS, testosterone, increases aggression towards females, and the enhanced aggression occurs only in response to provocation and in the presence of unreceptive females. Understanding and recognizing the predictive factors are expected to be useful in preventing AAS-induced aggression within the human population by the use of cognitive therapies.

KW - AAS

KW - Adolescence

KW - Dominance

KW - Mounting behavior

KW - Puberty

KW - Sex behavior

KW - Stanozolol

KW - Tail pinch

KW - Testosterone

KW - Violence

UR - http://www.scopus.com/inward/record.url?scp=33747187852&partnerID=8YFLogxK

U2 - 10.1016/j.yhbeh.2006.05.002

DO - 10.1016/j.yhbeh.2006.05.002

M3 - Article

C2 - 16870187

AN - SCOPUS:33747187852

SN - 0018-506X

VL - 50

SP - 410

EP - 416

JO - Hormones and Behavior

JF - Hormones and Behavior

IS - 3

ER -

Physical provocation of pubertal anabolic androgenic steroid exposed male rats elicits aggression towards females

Abstract

Keywords

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