Pharmacological induction of neuroglobin expression

Kunlin Jin, Xiao Ou Mao, Lin Xie, Varghese John, David A. Greenberg

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Neuroglobin (Ngb) is an intracellular, oxygen-binding neuronal protein with protective effects against ischemia and related pathological processes. To identify small molecules capable of inducing Ngb protein expression, which might have therapeutic benefit, we examined Ngb expression by Western blot in cultured HN33 (mouse hippocampal neuron ! N18TG2 neuroblastoma) cells. In addition to deferoxamine, which was shown previously to enhance Ngb levels, Ngb expression was increased by the short-chain fatty acids cinnamic acid and valproic acid (≥100 μmol/l), but not by other short-chain fatty acids, histone deacetylase inhibitors, or anticonvulsants. Drugs that stimulate the expression of neuroprotective proteins like Ngb may have therapeutic potential in the treatment of stroke and other neurological disorders.

Original languageEnglish
Pages (from-to)81-84
Number of pages4
JournalPharmacology
Volume87
Issue number1-2
DOIs
StatePublished - Feb 2011

Keywords

  • Cinnamic acid
  • Ischemia
  • Neuroglobin
  • Valproic acid

Fingerprint Dive into the research topics of 'Pharmacological induction of neuroglobin expression'. Together they form a unique fingerprint.

  • Cite this

    Jin, K., Mao, X. O., Xie, L., John, V., & Greenberg, D. A. (2011). Pharmacological induction of neuroglobin expression. Pharmacology, 87(1-2), 81-84. https://doi.org/10.1159/000322998