Pharmacological induction of neuroglobin expression

Kunlin Jin, Xiao Ou Mao, Lin Xie, Varghese John, David A. Greenberg

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Neuroglobin (Ngb) is an intracellular, oxygen-binding neuronal protein with protective effects against ischemia and related pathological processes. To identify small molecules capable of inducing Ngb protein expression, which might have therapeutic benefit, we examined Ngb expression by Western blot in cultured HN33 (mouse hippocampal neuron ! N18TG2 neuroblastoma) cells. In addition to deferoxamine, which was shown previously to enhance Ngb levels, Ngb expression was increased by the short-chain fatty acids cinnamic acid and valproic acid (≥100 μmol/l), but not by other short-chain fatty acids, histone deacetylase inhibitors, or anticonvulsants. Drugs that stimulate the expression of neuroprotective proteins like Ngb may have therapeutic potential in the treatment of stroke and other neurological disorders.

Original languageEnglish
Pages (from-to)81-84
Number of pages4
Issue number1-2
StatePublished - Feb 2011


  • Cinnamic acid
  • Ischemia
  • Neuroglobin
  • Valproic acid


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