Pharmacokinetics of anidulafungin in pleural fluid during the treatment of a patient with Candida empyema

Brad Moriyama, Marisa Ditullio, Eleanor Wilson, Stacey A. Henning, Scott R. Penzak, Robert L. Danner, Gennethel Pennick, Michael G. Rinaldi, Adrian M. Zelazny, Juan Gea-Banacloche, A. John Barrett, Thomas J. Walsh

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Candida empyema is a serious complication of disseminated candidiasis. However, little is known about the intrapleural pharmacokinetics of echinocandins. We report the penetration of anidulafungin into the pleural fluid of a patient with Candida tropicalis empyema. The anidulafungin ratio for the area under the concentration-time curve from 0 h to the last measurement between pleural fluid and serum values was only 0.125 (12.5%), with pleural fluid concentrations ranging between 0.67 and 0.88 μg/ml.

Original languageEnglish
Pages (from-to)2478-2480
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume55
Issue number5
DOIs
StatePublished - May 2011

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