Perioperative 18F-fluorodeoxyglucose-guided imaging using the becquerel as a quantitative measure for optimizing surgical resection in patients with advanced malignancy

Douglas A. Murrey; Eamonn E. Bahnson; Nathan C. Hall; Stephen P. Povoski; Cathy M. Mojzisik; Donn C. Young; Suhail Sharif; Morgan A. Johnson; Sherif Abdel-Misih; Edward W. Martin; Michael V. Knopp

doi:10.1016/j.amjsurg.2009.08.014

Perioperative ¹⁸F-fluorodeoxyglucose-guided imaging using the becquerel as a quantitative measure for optimizing surgical resection in patients with advanced malignancy

Douglas A. Murrey, Eamonn E. Bahnson, Nathan C. Hall, Stephen P. Povoski, Cathy M. Mojzisik, Donn C. Young, Suhail Sharif, Morgan A. Johnson, Sherif Abdel-Misih, Edward W. Martin, Michael V. Knopp

Medical Education & Health Systems Science

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) scanning is a widely accepted preoperative tumor imaging modality. Herein, we evaluate the becquerel (Bq) as a potential novel quantitative PET measure for application of surgical specimen imaging. Methods: Retrospectively, PET-avid lesions that could be followed from preoperative imaging, confidently identified in the operating room, imaged ex vivo, and correlated with histopathology were included in this study. Bq counts from both in vivo (preoperative) and ex vivo (surgical specimen) PET/CT images were measured and correlated with histopathology. Results: Fifty-five PET-avid lesions in 37 patients were included. Forty-six of 55 PET-avid lesions identified were found to contain malignancy on histopathology. Mean Bq counts for the PET-avid lesions were significantly higher that the adjacent PET-nonavid areas (background) within both in vivo and ex vivo imaging (P < .001 and P < .001, respectively). When analyzing all 55 lesions, we found significant increases in Bq levels. PET-avid lesions from in vivo to ex vivo images (P < .001) without significant increases in Bq levels in PET-nonavid lesions from in vivo to ex vivo images (P = .06). When comparing Bq levels between the 2 groups (malignant and benign), we found significantly higher Bq counts in the malignant group on in vivo imaging (P = .02) as well as significantly lower Bq counts in FDG-nonavid areas on ex vivo imaging (P = .04) within the malignant group. Significant differences in PET-avid to PET-nonavid Becquerels ratios within both in vivo and ex vivo images (P = .004, P = .002 respectively) were found, with ex vivo ratio being significantly higher (P < .001). Conclusions: ¹⁸F-FDG PET/CT imaging using Bqs is the potential to discern malignant lesions from benign tissues within both in vivo and ex vivo scans.

Original language	English
Pages (from-to)	834-840
Number of pages	7
Journal	American Journal of Surgery
Volume	198
Issue number	6
DOIs	https://doi.org/10.1016/j.amjsurg.2009.08.014
State	Published - 1 Dec 2009

Keywords

Becquerel
Computed tomography scans
Gamma probe
Imaging surgical specimens
Positron emission tomography
Tumor quantification

Access to Document

10.1016/j.amjsurg.2009.08.014

Cite this

Murrey, D. A., Bahnson, E. E., Hall, N. C., Povoski, S. P., Mojzisik, C. M., Young, D. C., Sharif, S., Johnson, M. A., Abdel-Misih, S., Martin, E. W., & Knopp, M. V. (2009). Perioperative ¹⁸F-fluorodeoxyglucose-guided imaging using the becquerel as a quantitative measure for optimizing surgical resection in patients with advanced malignancy. American Journal of Surgery, 198(6), 834-840. https://doi.org/10.1016/j.amjsurg.2009.08.014

@article{3f3c22fc61af4cf595a4cc83ac490011,

title = "Perioperative 18F-fluorodeoxyglucose-guided imaging using the becquerel as a quantitative measure for optimizing surgical resection in patients with advanced malignancy",

abstract = "Background: 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) scanning is a widely accepted preoperative tumor imaging modality. Herein, we evaluate the becquerel (Bq) as a potential novel quantitative PET measure for application of surgical specimen imaging. Methods: Retrospectively, PET-avid lesions that could be followed from preoperative imaging, confidently identified in the operating room, imaged ex vivo, and correlated with histopathology were included in this study. Bq counts from both in vivo (preoperative) and ex vivo (surgical specimen) PET/CT images were measured and correlated with histopathology. Results: Fifty-five PET-avid lesions in 37 patients were included. Forty-six of 55 PET-avid lesions identified were found to contain malignancy on histopathology. Mean Bq counts for the PET-avid lesions were significantly higher that the adjacent PET-nonavid areas (background) within both in vivo and ex vivo imaging (P < .001 and P < .001, respectively). When analyzing all 55 lesions, we found significant increases in Bq levels. PET-avid lesions from in vivo to ex vivo images (P < .001) without significant increases in Bq levels in PET-nonavid lesions from in vivo to ex vivo images (P = .06). When comparing Bq levels between the 2 groups (malignant and benign), we found significantly higher Bq counts in the malignant group on in vivo imaging (P = .02) as well as significantly lower Bq counts in FDG-nonavid areas on ex vivo imaging (P = .04) within the malignant group. Significant differences in PET-avid to PET-nonavid Becquerels ratios within both in vivo and ex vivo images (P = .004, P = .002 respectively) were found, with ex vivo ratio being significantly higher (P < .001). Conclusions: 18F-FDG PET/CT imaging using Bqs is the potential to discern malignant lesions from benign tissues within both in vivo and ex vivo scans.",

keywords = "Becquerel, Computed tomography scans, Gamma probe, Imaging surgical specimens, Positron emission tomography, Tumor quantification",

author = "Murrey, {Douglas A.} and Bahnson, {Eamonn E.} and Hall, {Nathan C.} and Povoski, {Stephen P.} and Mojzisik, {Cathy M.} and Young, {Donn C.} and Suhail Sharif and Johnson, {Morgan A.} and Sherif Abdel-Misih and Martin, {Edward W.} and Knopp, {Michael V.}",

year = "2009",

month = dec,

day = "1",

doi = "10.1016/j.amjsurg.2009.08.014",

language = "English",

volume = "198",

pages = "834--840",

journal = "American Journal of Surgery",

issn = "0002-9610",

publisher = "Elsevier Inc.",

number = "6",

}

Murrey, DA, Bahnson, EE, Hall, NC, Povoski, SP, Mojzisik, CM, Young, DC, Sharif, S, Johnson, MA, Abdel-Misih, S, Martin, EW & Knopp, MV 2009, 'Perioperative ¹⁸F-fluorodeoxyglucose-guided imaging using the becquerel as a quantitative measure for optimizing surgical resection in patients with advanced malignancy', American Journal of Surgery, vol. 198, no. 6, pp. 834-840. https://doi.org/10.1016/j.amjsurg.2009.08.014

Perioperative ¹⁸F-fluorodeoxyglucose-guided imaging using the becquerel as a quantitative measure for optimizing surgical resection in patients with advanced malignancy. / Murrey, Douglas A.; Bahnson, Eamonn E.; Hall, Nathan C. et al.
In: American Journal of Surgery, Vol. 198, No. 6, 01.12.2009, p. 834-840.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Perioperative 18F-fluorodeoxyglucose-guided imaging using the becquerel as a quantitative measure for optimizing surgical resection in patients with advanced malignancy

AU - Murrey, Douglas A.

AU - Bahnson, Eamonn E.

AU - Hall, Nathan C.

AU - Povoski, Stephen P.

AU - Mojzisik, Cathy M.

AU - Young, Donn C.

AU - Sharif, Suhail

AU - Johnson, Morgan A.

AU - Abdel-Misih, Sherif

AU - Martin, Edward W.

AU - Knopp, Michael V.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Background: 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) scanning is a widely accepted preoperative tumor imaging modality. Herein, we evaluate the becquerel (Bq) as a potential novel quantitative PET measure for application of surgical specimen imaging. Methods: Retrospectively, PET-avid lesions that could be followed from preoperative imaging, confidently identified in the operating room, imaged ex vivo, and correlated with histopathology were included in this study. Bq counts from both in vivo (preoperative) and ex vivo (surgical specimen) PET/CT images were measured and correlated with histopathology. Results: Fifty-five PET-avid lesions in 37 patients were included. Forty-six of 55 PET-avid lesions identified were found to contain malignancy on histopathology. Mean Bq counts for the PET-avid lesions were significantly higher that the adjacent PET-nonavid areas (background) within both in vivo and ex vivo imaging (P < .001 and P < .001, respectively). When analyzing all 55 lesions, we found significant increases in Bq levels. PET-avid lesions from in vivo to ex vivo images (P < .001) without significant increases in Bq levels in PET-nonavid lesions from in vivo to ex vivo images (P = .06). When comparing Bq levels between the 2 groups (malignant and benign), we found significantly higher Bq counts in the malignant group on in vivo imaging (P = .02) as well as significantly lower Bq counts in FDG-nonavid areas on ex vivo imaging (P = .04) within the malignant group. Significant differences in PET-avid to PET-nonavid Becquerels ratios within both in vivo and ex vivo images (P = .004, P = .002 respectively) were found, with ex vivo ratio being significantly higher (P < .001). Conclusions: 18F-FDG PET/CT imaging using Bqs is the potential to discern malignant lesions from benign tissues within both in vivo and ex vivo scans.

AB - Background: 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) scanning is a widely accepted preoperative tumor imaging modality. Herein, we evaluate the becquerel (Bq) as a potential novel quantitative PET measure for application of surgical specimen imaging. Methods: Retrospectively, PET-avid lesions that could be followed from preoperative imaging, confidently identified in the operating room, imaged ex vivo, and correlated with histopathology were included in this study. Bq counts from both in vivo (preoperative) and ex vivo (surgical specimen) PET/CT images were measured and correlated with histopathology. Results: Fifty-five PET-avid lesions in 37 patients were included. Forty-six of 55 PET-avid lesions identified were found to contain malignancy on histopathology. Mean Bq counts for the PET-avid lesions were significantly higher that the adjacent PET-nonavid areas (background) within both in vivo and ex vivo imaging (P < .001 and P < .001, respectively). When analyzing all 55 lesions, we found significant increases in Bq levels. PET-avid lesions from in vivo to ex vivo images (P < .001) without significant increases in Bq levels in PET-nonavid lesions from in vivo to ex vivo images (P = .06). When comparing Bq levels between the 2 groups (malignant and benign), we found significantly higher Bq counts in the malignant group on in vivo imaging (P = .02) as well as significantly lower Bq counts in FDG-nonavid areas on ex vivo imaging (P = .04) within the malignant group. Significant differences in PET-avid to PET-nonavid Becquerels ratios within both in vivo and ex vivo images (P = .004, P = .002 respectively) were found, with ex vivo ratio being significantly higher (P < .001). Conclusions: 18F-FDG PET/CT imaging using Bqs is the potential to discern malignant lesions from benign tissues within both in vivo and ex vivo scans.

KW - Becquerel

KW - Computed tomography scans

KW - Gamma probe

KW - Imaging surgical specimens

KW - Positron emission tomography

KW - Tumor quantification

UR - http://www.scopus.com/inward/record.url?scp=71149105709&partnerID=8YFLogxK

U2 - 10.1016/j.amjsurg.2009.08.014

DO - 10.1016/j.amjsurg.2009.08.014

M3 - Article

C2 - 19969138

AN - SCOPUS:71149105709

SN - 0002-9610

VL - 198

SP - 834

EP - 840

JO - American Journal of Surgery

JF - American Journal of Surgery

IS - 6

ER -

Perioperative ¹⁸F-fluorodeoxyglucose-guided imaging using the becquerel as a quantitative measure for optimizing surgical resection in patients with advanced malignancy

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this