Perforin: More than just an effector molecule

Susan E. Stepp, Porunelloor A. Mathew, Michael Bennett, Geneviève De Saint Basile, Vinay Kumar

Research output: Contribution to journalShort surveypeer-review

106 Scopus citations


Perforin mediates the destruction of virus-infected or transformed cells. However, the finding that perforin deficiency is the underlying cause of familial hemophagocytic lymphohistiocytosis indicates that it also regulates the immune response.

Original languageEnglish
Pages (from-to)254-256
Number of pages3
JournalImmunology Today
Issue number6
StatePublished - 1 Jun 2000


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