Perforin: More than just an effector molecule

Susan E. Stepp; Porunelloor A. Mathew; Michael Bennett; Geneviève De Saint Basile; Vinay Kumar

doi:10.1016/S0167-5699(00)01622-4

Perforin: More than just an effector molecule

Susan E. Stepp, Porunelloor A. Mathew, Michael Bennett, Geneviève De Saint Basile, Vinay Kumar

Research output: Contribution to journal › Short survey › peer-review

106 Scopus citations

Abstract

Perforin mediates the destruction of virus-infected or transformed cells. However, the finding that perforin deficiency is the underlying cause of familial hemophagocytic lymphohistiocytosis indicates that it also regulates the immune response.

Original language	English
Pages (from-to)	254-256
Number of pages	3
Journal	Immunology Today
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/S0167-5699(00)01622-4
State	Published - 1 Jun 2000

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title = "Perforin: More than just an effector molecule",

abstract = "Perforin mediates the destruction of virus-infected or transformed cells. However, the finding that perforin deficiency is the underlying cause of familial hemophagocytic lymphohistiocytosis indicates that it also regulates the immune response.",

author = "Stepp, {Susan E.} and Mathew, {Porunelloor A.} and Michael Bennett and {De Saint Basile}, Genevi{\`e}ve and Vinay Kumar",

year = "2000",

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T2 - More than just an effector molecule

AU - Stepp, Susan E.

AU - Mathew, Porunelloor A.

AU - Bennett, Michael

AU - De Saint Basile, Geneviève

AU - Kumar, Vinay

PY - 2000/6/1

Y1 - 2000/6/1

N2 - Perforin mediates the destruction of virus-infected or transformed cells. However, the finding that perforin deficiency is the underlying cause of familial hemophagocytic lymphohistiocytosis indicates that it also regulates the immune response.

AB - Perforin mediates the destruction of virus-infected or transformed cells. However, the finding that perforin deficiency is the underlying cause of familial hemophagocytic lymphohistiocytosis indicates that it also regulates the immune response.

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U2 - 10.1016/S0167-5699(00)01622-4

DO - 10.1016/S0167-5699(00)01622-4

M3 - Short survey

C2 - 10825735

AN - SCOPUS:0034087520

SN - 0167-5699

VL - 21

SP - 254

EP - 256

JO - Immunology Today

JF - Immunology Today

IS - 6

ER -

Perforin: More than just an effector molecule

Abstract

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