Peptidic prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Yang I. Lin; Panayota Bitha; Subas M. Sakya; Zhong Li; Stanley A. Lang; Youjun Yang; Niraja Bhachech; William J. Weiss; Peter J. Petersen; Nilda V. Jacobus; Karen Bush; Raymond T. Testa

doi:10.1016/S0960-894X(97)00281-3

Peptidic prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Yang I. Lin, Panayota Bitha, Subas M. Sakya, Zhong Li, Stanley A. Lang, Youjun Yang, Niraja Bhachech, William J. Weiss, Peter J. Petersen, Nilda V. Jacobus, Karen Bush, Raymond T. Testa

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Abstract

Peptidic prodrugs of the five most active aminomethyl-THF β- methylcarbapenems were synthesized. Of these, only L-amino acid derivatives from la demonstrated an improved oral activity. These results indicate that the L-amino acid derivatives from la are orally absorbed most likely through the dipeptide and tripeptide transport mechanism.

Original language	English
Pages (from-to)	1665-1670
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	13
DOIs	https://doi.org/10.1016/S0960-894X(97)00281-3
State	Published - 8 Jul 1997

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title = "Peptidic prodrugs of novel aminomethyl-THF 1β-methylcarbapenems",

abstract = "Peptidic prodrugs of the five most active aminomethyl-THF β- methylcarbapenems were synthesized. Of these, only L-amino acid derivatives from la demonstrated an improved oral activity. These results indicate that the L-amino acid derivatives from la are orally absorbed most likely through the dipeptide and tripeptide transport mechanism.",

author = "Lin, {Yang I.} and Panayota Bitha and Sakya, {Subas M.} and Zhong Li and Lang, {Stanley A.} and Youjun Yang and Niraja Bhachech and Weiss, {William J.} and Petersen, {Peter J.} and Jacobus, {Nilda V.} and Karen Bush and Testa, {Raymond T.}",

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TY - JOUR

T1 - Peptidic prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

AU - Lin, Yang I.

AU - Bitha, Panayota

AU - Sakya, Subas M.

AU - Li, Zhong

AU - Lang, Stanley A.

AU - Yang, Youjun

AU - Bhachech, Niraja

AU - Weiss, William J.

AU - Petersen, Peter J.

AU - Jacobus, Nilda V.

AU - Bush, Karen

AU - Testa, Raymond T.

PY - 1997/7/8

Y1 - 1997/7/8

N2 - Peptidic prodrugs of the five most active aminomethyl-THF β- methylcarbapenems were synthesized. Of these, only L-amino acid derivatives from la demonstrated an improved oral activity. These results indicate that the L-amino acid derivatives from la are orally absorbed most likely through the dipeptide and tripeptide transport mechanism.

AB - Peptidic prodrugs of the five most active aminomethyl-THF β- methylcarbapenems were synthesized. Of these, only L-amino acid derivatives from la demonstrated an improved oral activity. These results indicate that the L-amino acid derivatives from la are orally absorbed most likely through the dipeptide and tripeptide transport mechanism.

UR - http://www.scopus.com/inward/record.url?scp=0030812297&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(97)00281-3

DO - 10.1016/S0960-894X(97)00281-3

M3 - Article

AN - SCOPUS:0030812297

SN - 0960-894X

VL - 7

SP - 1665

EP - 1670

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

ER -

Peptidic prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Abstract

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