TY - JOUR
T1 - Pathway specificity of l-isoproterenol indicates β-adrenergic modulation of the Schaffer collateral pathway in field CA1 in the rat hippocampal slice
AU - Nejtek, Vicki
AU - Dahl, Dennis
PY - 1997/1/1
Y1 - 1997/1/1
N2 - Behavioral relevance of norepinephrine is associated with neuronal processing underlying arousal, affect, attention, learning and memory, and is associated with β-adrenergic modifications of neuronal activation in the hippocampal formation. This study utilized l-isoproterenol to initiate pathway-specific activation of afferents to hippocampal CA1 pyramidal cells. The consistent effects of l-isoproterenol on the initiation of action potentials to field CA1 pyramidal neurons to single-pulse stimulation was repeatedly associated with the activation of the Schaffer collateral pathway. In contrast, l-isoproterenol plus single-pulse stimulation never elicited action potential initiation of the perforant pathway to CA1. We interpret these results as indicating that β-adrenergic modification underlies the augmentation of information processing via the Schaffer collateral pathway in the trisynaptic circuit vs the direct perforant pathway.
AB - Behavioral relevance of norepinephrine is associated with neuronal processing underlying arousal, affect, attention, learning and memory, and is associated with β-adrenergic modifications of neuronal activation in the hippocampal formation. This study utilized l-isoproterenol to initiate pathway-specific activation of afferents to hippocampal CA1 pyramidal cells. The consistent effects of l-isoproterenol on the initiation of action potentials to field CA1 pyramidal neurons to single-pulse stimulation was repeatedly associated with the activation of the Schaffer collateral pathway. In contrast, l-isoproterenol plus single-pulse stimulation never elicited action potential initiation of the perforant pathway to CA1. We interpret these results as indicating that β-adrenergic modification underlies the augmentation of information processing via the Schaffer collateral pathway in the trisynaptic circuit vs the direct perforant pathway.
KW - hippocampal field CA1
KW - information processing
KW - l-isoproterenol
KW - norepinephrine
KW - β-adrenergic pathway specificity
UR - http://www.scopus.com/inward/record.url?scp=0030887791&partnerID=8YFLogxK
U2 - 10.1097/00001756-199702100-00033
DO - 10.1097/00001756-199702100-00033
M3 - Article
C2 - 9106759
AN - SCOPUS:0030887791
SN - 0959-4965
VL - 8
SP - 745
EP - 749
JO - NeuroReport
JF - NeuroReport
IS - 3
ER -