Pathway specificity of l-isoproterenol indicates β-adrenergic modulation of the Schaffer collateral pathway in field CA1 in the rat hippocampal slice

Vicki Nejtek, Dennis Dahl

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Behavioral relevance of norepinephrine is associated with neuronal processing underlying arousal, affect, attention, learning and memory, and is associated with β-adrenergic modifications of neuronal activation in the hippocampal formation. This study utilized l-isoproterenol to initiate pathway-specific activation of afferents to hippocampal CA1 pyramidal cells. The consistent effects of l-isoproterenol on the initiation of action potentials to field CA1 pyramidal neurons to single-pulse stimulation was repeatedly associated with the activation of the Schaffer collateral pathway. In contrast, l-isoproterenol plus single-pulse stimulation never elicited action potential initiation of the perforant pathway to CA1. We interpret these results as indicating that β-adrenergic modification underlies the augmentation of information processing via the Schaffer collateral pathway in the trisynaptic circuit vs the direct perforant pathway.

Original languageEnglish
Pages (from-to)745-749
Number of pages5
JournalNeuroReport
Volume8
Issue number3
DOIs
StatePublished - 1 Jan 1997

Keywords

  • hippocampal field CA1
  • information processing
  • l-isoproterenol
  • norepinephrine
  • β-adrenergic pathway specificity

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