Pathophysiology and clinical presentation of gastroesophageal reflux disease

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Gastroesophageal reflux disease is a common problem that results from a complex interplay of several pathophysiologic mechanisms. The lower esophageal sphincter has a major role in maintaining a barrier between the stomach's hostile environment and the less adaptable esophagus; therefore, dysfunction of the lower esophageal sphincter is a key contributing component in the pathophysiology of gastroesophageal reflux disease. Alterations in esophageal clearance and tissue resistance contribute to a lesser degree to gastroesophageal reflux disease. The disease also has a variety of clinical presentations. Classification into classic, atypical, and alarm symptoms improves recognition. Understanding symptom presentation through pathophysiologic correlation will help the clinician manage this common disorder.

Original languageEnglish
Pages (from-to)S1-S4
JournalJournal of the American Osteopathic Association
Issue number9 SUPPL. 1
StatePublished - 1 Dec 1997


  • Esophageal motility
  • Esophagus
  • Gastroesophageal reflux disease
  • Lower esophageal sphincter
  • Peristalsis
  • Stomach


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