Abstract
Gastroesophageal reflux disease is a common problem that results from a complex interplay of several pathophysiologic mechanisms. The lower esophageal sphincter has a major role in maintaining a barrier between the stomach's hostile environment and the less adaptable esophagus; therefore, dysfunction of the lower esophageal sphincter is a key contributing component in the pathophysiology of gastroesophageal reflux disease. Alterations in esophageal clearance and tissue resistance contribute to a lesser degree to gastroesophageal reflux disease. The disease also has a variety of clinical presentations. Classification into classic, atypical, and alarm symptoms improves recognition. Understanding symptom presentation through pathophysiologic correlation will help the clinician manage this common disorder.
Original language | English |
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Pages (from-to) | S1-S4 |
Journal | Journal of the American Osteopathic Association |
Volume | 97 |
Issue number | 9 SUPPL. 1 |
State | Published - 1 Dec 1997 |
Keywords
- Esophageal motility
- Esophagus
- Gastroesophageal reflux disease
- Lower esophageal sphincter
- Peristalsis
- Stomach