TY - JOUR
T1 - Paternity testing with genetic markers
T2 - Are Y-linked genes more efficient than autosomal ones?
AU - Chakraborty, R.
PY - 1985
Y1 - 1985
N2 - The average probability of exclusion for a Y-linked locus is computed and compared with that for an autosomal locus. It is shown that even if a Y-linked locus is only marginally polymorphic, it considerably enhances the chance of paternity exclusion in paternity dispute cases involving sons. For the positive identification of paternity, a Y-linked marker is not necessarily more ideal than an analogous autosomal marker since the discrimination of true fathers from random men not excluded from paternity (RMNEP) is still difficult on the basis of a paternity index. It is concluded that Y-linked markers are more efficient for paternity exclusions of male children, while for the positive identification of paternity their advantages over the autosomal markers are questionable.
AB - The average probability of exclusion for a Y-linked locus is computed and compared with that for an autosomal locus. It is shown that even if a Y-linked locus is only marginally polymorphic, it considerably enhances the chance of paternity exclusion in paternity dispute cases involving sons. For the positive identification of paternity, a Y-linked marker is not necessarily more ideal than an analogous autosomal marker since the discrimination of true fathers from random men not excluded from paternity (RMNEP) is still difficult on the basis of a paternity index. It is concluded that Y-linked markers are more efficient for paternity exclusions of male children, while for the positive identification of paternity their advantages over the autosomal markers are questionable.
UR - http://www.scopus.com/inward/record.url?scp=0021836893&partnerID=8YFLogxK
U2 - 10.1002/ajmg.1320210212
DO - 10.1002/ajmg.1320210212
M3 - Article
C2 - 3860007
AN - SCOPUS:0021836893
SN - 0148-7299
VL - 21
SP - 297
EP - 305
JO - American Journal of Medical Genetics
JF - American Journal of Medical Genetics
IS - 2
ER -