Part 2 - Coronary angiography with gadofosveset trisodium: A prospective intra-subject comparison for dose optimization for 100 % efficiency imaging

Mark A. Ahlman, Fabio S. Raman, Jianing Pang, Filip Zemrak, Veit Sandfort, Scott Robert Penzak, Zhaoyang Fan, Songtao Liu, Debiao Li, David A. Bluemke

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Three tesla (3T) coronary magnetic resonance angiography (MRA) may be optimized using gadolinium-based contrast agents (GBCA) such as gadofosveset trisodium. The goal of this study was to evaluate if there is a qualitative or quantitative improvement in the coronary arteries with variation in contrast dose. Methods: Twenty-eight healthy volunteers were prospectively recruited for coronary MRA at 3T using a steady state injection technique for 3D radial whole-heart image acquisition with retrospective respiratory self-gating (ClinicalTrials.gov identifier: NCT01853592). Nineteen volunteers completed both single- and double-dose imaging instances (0.03 and 0.06 mmol/kg, respectively). Intra-individual comparison of image quality was assessed by measurement of apparent signal/contrast-to-noise ratio (aSNR/aCNR) and subjective evaluation of image quality by 2 independent reviewers. Results: The average duration of coronary MRA acquisition was 7.2 ± 1.2 min. There was significantly higher (60 %, p < 0.001) aSNR of the aorta and right/left ventricle for the double dose compared to single dose injection scheme and aSNR of the coronary arteries increased by 70 % (p < 0.001) for the double dose injection. aCNR increased by +55 % and +60 % in the ventricles and coronary arteries, respectively (p < 0.001). Overall segmental artery visualization for single dose was possible 47 % of the time, which improved to 60 % with double dose (p = 0.019), predominantly driven by improvements in more distal segment visualization (+40 % improvement in mid arterial segments, p = 0.013). Conclusions: Gadofosveset trisodium dose of 0.06 mmol/kg significantly quantitatively and qualitatively improves the coronary artery image quality compared to 0.03 mmol/kg at 3T for moderate duration (6-8 min) steady state contrast enhanced coronary MRA.

Original languageEnglish
Article number58
JournalBMC Cardiovascular Disorders
Volume16
Issue number1
DOIs
StatePublished - 1 Jan 2016

Fingerprint

Magnetic Resonance Angiography
Coronary Angiography
Coronary Vessels
Injections
Heart Ventricles
Gadolinium
Signal-To-Noise Ratio
Contrast Media
Aorta
Volunteers
Healthy Volunteers
Arteries
gadofosveset trisodium

Keywords

  • 3.0 Tesla
  • Gadofosveset trisodium
  • Gadolinium-based intravascular contrast agent
  • Image quality
  • MS-325
  • Navigator-based angiography
  • Respiratory motion correction
  • Whole-heart coronary magnetic resonance angiography

Cite this

Ahlman, Mark A. ; Raman, Fabio S. ; Pang, Jianing ; Zemrak, Filip ; Sandfort, Veit ; Penzak, Scott Robert ; Fan, Zhaoyang ; Liu, Songtao ; Li, Debiao ; Bluemke, David A. / Part 2 - Coronary angiography with gadofosveset trisodium : A prospective intra-subject comparison for dose optimization for 100 % efficiency imaging. In: BMC Cardiovascular Disorders. 2016 ; Vol. 16, No. 1.
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abstract = "Background: Three tesla (3T) coronary magnetic resonance angiography (MRA) may be optimized using gadolinium-based contrast agents (GBCA) such as gadofosveset trisodium. The goal of this study was to evaluate if there is a qualitative or quantitative improvement in the coronary arteries with variation in contrast dose. Methods: Twenty-eight healthy volunteers were prospectively recruited for coronary MRA at 3T using a steady state injection technique for 3D radial whole-heart image acquisition with retrospective respiratory self-gating (ClinicalTrials.gov identifier: NCT01853592). Nineteen volunteers completed both single- and double-dose imaging instances (0.03 and 0.06 mmol/kg, respectively). Intra-individual comparison of image quality was assessed by measurement of apparent signal/contrast-to-noise ratio (aSNR/aCNR) and subjective evaluation of image quality by 2 independent reviewers. Results: The average duration of coronary MRA acquisition was 7.2 ± 1.2 min. There was significantly higher (60 {\%}, p < 0.001) aSNR of the aorta and right/left ventricle for the double dose compared to single dose injection scheme and aSNR of the coronary arteries increased by 70 {\%} (p < 0.001) for the double dose injection. aCNR increased by +55 {\%} and +60 {\%} in the ventricles and coronary arteries, respectively (p < 0.001). Overall segmental artery visualization for single dose was possible 47 {\%} of the time, which improved to 60 {\%} with double dose (p = 0.019), predominantly driven by improvements in more distal segment visualization (+40 {\%} improvement in mid arterial segments, p = 0.013). Conclusions: Gadofosveset trisodium dose of 0.06 mmol/kg significantly quantitatively and qualitatively improves the coronary artery image quality compared to 0.03 mmol/kg at 3T for moderate duration (6-8 min) steady state contrast enhanced coronary MRA.",
keywords = "3.0 Tesla, Gadofosveset trisodium, Gadolinium-based intravascular contrast agent, Image quality, MS-325, Navigator-based angiography, Respiratory motion correction, Whole-heart coronary magnetic resonance angiography",
author = "Ahlman, {Mark A.} and Raman, {Fabio S.} and Jianing Pang and Filip Zemrak and Veit Sandfort and Penzak, {Scott Robert} and Zhaoyang Fan and Songtao Liu and Debiao Li and Bluemke, {David A.}",
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Part 2 - Coronary angiography with gadofosveset trisodium : A prospective intra-subject comparison for dose optimization for 100 % efficiency imaging. / Ahlman, Mark A.; Raman, Fabio S.; Pang, Jianing; Zemrak, Filip; Sandfort, Veit; Penzak, Scott Robert; Fan, Zhaoyang; Liu, Songtao; Li, Debiao; Bluemke, David A.

In: BMC Cardiovascular Disorders, Vol. 16, No. 1, 58, 01.01.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Part 2 - Coronary angiography with gadofosveset trisodium

T2 - A prospective intra-subject comparison for dose optimization for 100 % efficiency imaging

AU - Ahlman, Mark A.

AU - Raman, Fabio S.

AU - Pang, Jianing

AU - Zemrak, Filip

AU - Sandfort, Veit

AU - Penzak, Scott Robert

AU - Fan, Zhaoyang

AU - Liu, Songtao

AU - Li, Debiao

AU - Bluemke, David A.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: Three tesla (3T) coronary magnetic resonance angiography (MRA) may be optimized using gadolinium-based contrast agents (GBCA) such as gadofosveset trisodium. The goal of this study was to evaluate if there is a qualitative or quantitative improvement in the coronary arteries with variation in contrast dose. Methods: Twenty-eight healthy volunteers were prospectively recruited for coronary MRA at 3T using a steady state injection technique for 3D radial whole-heart image acquisition with retrospective respiratory self-gating (ClinicalTrials.gov identifier: NCT01853592). Nineteen volunteers completed both single- and double-dose imaging instances (0.03 and 0.06 mmol/kg, respectively). Intra-individual comparison of image quality was assessed by measurement of apparent signal/contrast-to-noise ratio (aSNR/aCNR) and subjective evaluation of image quality by 2 independent reviewers. Results: The average duration of coronary MRA acquisition was 7.2 ± 1.2 min. There was significantly higher (60 %, p < 0.001) aSNR of the aorta and right/left ventricle for the double dose compared to single dose injection scheme and aSNR of the coronary arteries increased by 70 % (p < 0.001) for the double dose injection. aCNR increased by +55 % and +60 % in the ventricles and coronary arteries, respectively (p < 0.001). Overall segmental artery visualization for single dose was possible 47 % of the time, which improved to 60 % with double dose (p = 0.019), predominantly driven by improvements in more distal segment visualization (+40 % improvement in mid arterial segments, p = 0.013). Conclusions: Gadofosveset trisodium dose of 0.06 mmol/kg significantly quantitatively and qualitatively improves the coronary artery image quality compared to 0.03 mmol/kg at 3T for moderate duration (6-8 min) steady state contrast enhanced coronary MRA.

AB - Background: Three tesla (3T) coronary magnetic resonance angiography (MRA) may be optimized using gadolinium-based contrast agents (GBCA) such as gadofosveset trisodium. The goal of this study was to evaluate if there is a qualitative or quantitative improvement in the coronary arteries with variation in contrast dose. Methods: Twenty-eight healthy volunteers were prospectively recruited for coronary MRA at 3T using a steady state injection technique for 3D radial whole-heart image acquisition with retrospective respiratory self-gating (ClinicalTrials.gov identifier: NCT01853592). Nineteen volunteers completed both single- and double-dose imaging instances (0.03 and 0.06 mmol/kg, respectively). Intra-individual comparison of image quality was assessed by measurement of apparent signal/contrast-to-noise ratio (aSNR/aCNR) and subjective evaluation of image quality by 2 independent reviewers. Results: The average duration of coronary MRA acquisition was 7.2 ± 1.2 min. There was significantly higher (60 %, p < 0.001) aSNR of the aorta and right/left ventricle for the double dose compared to single dose injection scheme and aSNR of the coronary arteries increased by 70 % (p < 0.001) for the double dose injection. aCNR increased by +55 % and +60 % in the ventricles and coronary arteries, respectively (p < 0.001). Overall segmental artery visualization for single dose was possible 47 % of the time, which improved to 60 % with double dose (p = 0.019), predominantly driven by improvements in more distal segment visualization (+40 % improvement in mid arterial segments, p = 0.013). Conclusions: Gadofosveset trisodium dose of 0.06 mmol/kg significantly quantitatively and qualitatively improves the coronary artery image quality compared to 0.03 mmol/kg at 3T for moderate duration (6-8 min) steady state contrast enhanced coronary MRA.

KW - 3.0 Tesla

KW - Gadofosveset trisodium

KW - Gadolinium-based intravascular contrast agent

KW - Image quality

KW - MS-325

KW - Navigator-based angiography

KW - Respiratory motion correction

KW - Whole-heart coronary magnetic resonance angiography

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U2 - 10.1186/s12872-015-0152-8

DO - 10.1186/s12872-015-0152-8

M3 - Article

C2 - 27004532

AN - SCOPUS:85007471120

VL - 16

JO - BMC Cardiovascular Disorders

JF - BMC Cardiovascular Disorders

SN - 1471-2261

IS - 1

M1 - 58

ER -