Ossabaw Island miniature swine: Cardiometabolic syndrome assessment

Michael Sturek; Mouhamad Alloosh; James Wenzel; James P. Byrd; Jason M. Edwards; Pamela G. Lloyd; Johnathan D. Tune; Keith L. March; Michael A. Miller; Eric A. Mokelke; I. Lehr Brisbin

Ossabaw Island miniature swine: Cardiometabolic syndrome assessment

Michael Sturek, Mouhamad Alloosh, James Wenzel, James P. Byrd, Jason M. Edwards, Pamela G. Lloyd, Johnathan D. Tune, Keith L. March, Michael A. Miller, Eric A. Mokelke, I. Lehr Brisbin

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

52 Scopus citations

Abstract

Ossabaw swine were deposited on Ossabaw Island, GA, in the 1500s by Spanish explorers (Mayer and Brisbin, Jr., 1991) and, since then, the ocean has remained an impenetrable barrier to emigration of Ossabaw pigs to the mainland. Natural models of disease that arise from adaptation of animals to unique selection pressures can give insights into similar complex, multifactorial diseases in humans. Ossabaw miniature swine may recapitulate the natural pathogenesis of type 2 diabetes because of their “thrifty genotype” that enabled survival in the feast and famine ecology of Ossabaw Island. The thrifty genotype hypothesis is that in the hunter-gatherer stages of human development the ability to store excess fat enabled survival during periods of famine (Neel, 1962).

Original language	English
Title of host publication	Swine in the Laboratory
Subtitle of host publication	Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition
Publisher	CRC Press
Pages	397-402
Number of pages	6
ISBN (Electronic)	9781420009156
ISBN (Print)	9780849392788
State	Published - 1 Jan 2007

Cite this

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title = "Ossabaw Island miniature swine: Cardiometabolic syndrome assessment",

abstract = "Ossabaw swine were deposited on Ossabaw Island, GA, in the 1500s by Spanish explorers (Mayer and Brisbin, Jr., 1991) and, since then, the ocean has remained an impenetrable barrier to emigration of Ossabaw pigs to the mainland. Natural models of disease that arise from adaptation of animals to unique selection pressures can give insights into similar complex, multifactorial diseases in humans. Ossabaw miniature swine may recapitulate the natural pathogenesis of type 2 diabetes because of their “thrifty genotype” that enabled survival in the feast and famine ecology of Ossabaw Island. The thrifty genotype hypothesis is that in the hunter-gatherer stages of human development the ability to store excess fat enabled survival during periods of famine (Neel, 1962).",

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AU - Sturek, Michael

AU - Alloosh, Mouhamad

AU - Wenzel, James

AU - Byrd, James P.

AU - Edwards, Jason M.

AU - Lloyd, Pamela G.

AU - Tune, Johnathan D.

AU - March, Keith L.

AU - Miller, Michael A.

AU - Mokelke, Eric A.

AU - Brisbin, I. Lehr

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AB - Ossabaw swine were deposited on Ossabaw Island, GA, in the 1500s by Spanish explorers (Mayer and Brisbin, Jr., 1991) and, since then, the ocean has remained an impenetrable barrier to emigration of Ossabaw pigs to the mainland. Natural models of disease that arise from adaptation of animals to unique selection pressures can give insights into similar complex, multifactorial diseases in humans. Ossabaw miniature swine may recapitulate the natural pathogenesis of type 2 diabetes because of their “thrifty genotype” that enabled survival in the feast and famine ecology of Ossabaw Island. The thrifty genotype hypothesis is that in the hunter-gatherer stages of human development the ability to store excess fat enabled survival during periods of famine (Neel, 1962).

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Ossabaw Island miniature swine: Cardiometabolic syndrome assessment

Abstract

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