Orthostatic hypotension in aging humans

Xiangrong Shi, D. Walter Wray, Kevin J. Formes, Hong Wei Wang, Patrick M. Hayes, Albert Yurvati, Martin S. Weiss, I. Philip Reese

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Abstract

We tested the hypothesis that hypotension occurred in older adults at the onset of orthostatic challenge as a result of vagal dysfunction. Responses of heart rate (HR) and mean arterial pressure (MAP) were compared between 10 healthy older and younger adults during onset and sustained lower body negative pressure (LBNP). A younger group was also assessed after blockade of the parasympathetic nervous system with the use of atropine or glycopyrrolate and after blockade of the β1-adrenoceptor by use of metoprolol. Baseline HR (older vs. younger: 59 ± 4 vs. 54 ± 1 beats/min) and MAP (83 ± 2 vs. 89 ± 3 mmHg) were not significantly different between the groups. During -40 Torr, significant tachycardia occurred at the first HR response in the younger subjects without hypotension, whereas significant hypotension [change in MAP (AMAP) -7 ± 2 mmHg] was observed in the elderly without tachycardia. After the parasympathetic blockade, tachycardiac responses of younger subjects were diminished and associated with a significant hypotension at the onset of LBNP. However, MAP was not affected after the cardiac sympathetic blockade. We concluded that the elderly experienced orthostatic hypotension at the onset of orthostatic challenge because of a diminished HR response. However, an augmented vasoconstriction helped with the maintenance of their blood pressure during sustained LBNP.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume279
Issue number4 48-4
StatePublished - 7 Dec 2000

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Orthostatic Hypotension
Lower Body Negative Pressure
Hypotension
Arterial Pressure
Heart Rate
Tachycardia
Glycopyrrolate
Parasympathetic Nervous System
Metoprolol
Vasoconstriction
Atropine
Adrenergic Receptors
Young Adult
Maintenance
Blood Pressure

Keywords

  • Atropine
  • Glycopyrrolate
  • Lower body negative pressure
  • Metoprolol
  • Tachycardiac response
  • Vagal dysfunction

Cite this

Shi, X., Wray, D. W., Formes, K. J., Wang, H. W., Hayes, P. M., Yurvati, A., ... Reese, I. P. (2000). Orthostatic hypotension in aging humans. American Journal of Physiology - Heart and Circulatory Physiology, 279(4 48-4).
Shi, Xiangrong ; Wray, D. Walter ; Formes, Kevin J. ; Wang, Hong Wei ; Hayes, Patrick M. ; Yurvati, Albert ; Weiss, Martin S. ; Reese, I. Philip. / Orthostatic hypotension in aging humans. In: American Journal of Physiology - Heart and Circulatory Physiology. 2000 ; Vol. 279, No. 4 48-4.
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Shi, X, Wray, DW, Formes, KJ, Wang, HW, Hayes, PM, Yurvati, A, Weiss, MS & Reese, IP 2000, 'Orthostatic hypotension in aging humans', American Journal of Physiology - Heart and Circulatory Physiology, vol. 279, no. 4 48-4.

Orthostatic hypotension in aging humans. / Shi, Xiangrong; Wray, D. Walter; Formes, Kevin J.; Wang, Hong Wei; Hayes, Patrick M.; Yurvati, Albert; Weiss, Martin S.; Reese, I. Philip.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 279, No. 4 48-4, 07.12.2000.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Orthostatic hypotension in aging humans

AU - Shi, Xiangrong

AU - Wray, D. Walter

AU - Formes, Kevin J.

AU - Wang, Hong Wei

AU - Hayes, Patrick M.

AU - Yurvati, Albert

AU - Weiss, Martin S.

AU - Reese, I. Philip

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N2 - We tested the hypothesis that hypotension occurred in older adults at the onset of orthostatic challenge as a result of vagal dysfunction. Responses of heart rate (HR) and mean arterial pressure (MAP) were compared between 10 healthy older and younger adults during onset and sustained lower body negative pressure (LBNP). A younger group was also assessed after blockade of the parasympathetic nervous system with the use of atropine or glycopyrrolate and after blockade of the β1-adrenoceptor by use of metoprolol. Baseline HR (older vs. younger: 59 ± 4 vs. 54 ± 1 beats/min) and MAP (83 ± 2 vs. 89 ± 3 mmHg) were not significantly different between the groups. During -40 Torr, significant tachycardia occurred at the first HR response in the younger subjects without hypotension, whereas significant hypotension [change in MAP (AMAP) -7 ± 2 mmHg] was observed in the elderly without tachycardia. After the parasympathetic blockade, tachycardiac responses of younger subjects were diminished and associated with a significant hypotension at the onset of LBNP. However, MAP was not affected after the cardiac sympathetic blockade. We concluded that the elderly experienced orthostatic hypotension at the onset of orthostatic challenge because of a diminished HR response. However, an augmented vasoconstriction helped with the maintenance of their blood pressure during sustained LBNP.

AB - We tested the hypothesis that hypotension occurred in older adults at the onset of orthostatic challenge as a result of vagal dysfunction. Responses of heart rate (HR) and mean arterial pressure (MAP) were compared between 10 healthy older and younger adults during onset and sustained lower body negative pressure (LBNP). A younger group was also assessed after blockade of the parasympathetic nervous system with the use of atropine or glycopyrrolate and after blockade of the β1-adrenoceptor by use of metoprolol. Baseline HR (older vs. younger: 59 ± 4 vs. 54 ± 1 beats/min) and MAP (83 ± 2 vs. 89 ± 3 mmHg) were not significantly different between the groups. During -40 Torr, significant tachycardia occurred at the first HR response in the younger subjects without hypotension, whereas significant hypotension [change in MAP (AMAP) -7 ± 2 mmHg] was observed in the elderly without tachycardia. After the parasympathetic blockade, tachycardiac responses of younger subjects were diminished and associated with a significant hypotension at the onset of LBNP. However, MAP was not affected after the cardiac sympathetic blockade. We concluded that the elderly experienced orthostatic hypotension at the onset of orthostatic challenge because of a diminished HR response. However, an augmented vasoconstriction helped with the maintenance of their blood pressure during sustained LBNP.

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JO - American Journal of Physiology - Heart and Circulatory Physiology

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SN - 0363-6135

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