Origin and bioactivities of thiosulfinated FK228

Xiangyang Liu, Grant C. Currens, Liang Xue, Yi Qiang Cheng

Research output: Contribution to journalArticle

Abstract

During a large laboratory-scale purification of FK228 from the fermentation broth of Burkholderia thailandensis MSMB43, a small amount of thiosulfinated FK228 (TS-FK228) was unexpectedly purified only after the broth was mixed with silica gel. Evidence supports the postulations that TS-FK228 was derived from FK228 through spontaneous chemical reaction with silica gel, and TS-FK228 existed as two isomers 1 and 2. TS-FK228 demonstrated similar inhibitory activity and profile against human class I histone deacetylases but exhibited a much higher antiproliferative activity against representative human cancer cell lines when compared to FK228.

Original languageEnglish
Pages (from-to)538-542
Number of pages5
JournalMedChemComm
Volume10
Issue number4
DOIs
StatePublished - 2019

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