Origin and bioactivities of thiosulfinated FK228

Xiangyang Liu; Grant C. Currens; Liang Xue; Yi Qiang Cheng

doi:10.1039/c9md00060g

Origin and bioactivities of thiosulfinated FK228

Xiangyang Liu, Grant C. Currens, Liang Xue, Yi Qiang Cheng

Research output: Contribution to journal › Article › peer-review

Abstract

During a large laboratory-scale purification of FK228 from the fermentation broth of Burkholderia thailandensis MSMB43, a small amount of thiosulfinated FK228 (TS-FK228) was unexpectedly purified only after the broth was mixed with silica gel. Evidence supports the postulations that TS-FK228 was derived from FK228 through spontaneous chemical reaction with silica gel, and TS-FK228 existed as two isomers 1 and 2. TS-FK228 demonstrated similar inhibitory activity and profile against human class I histone deacetylases but exhibited a much higher antiproliferative activity against representative human cancer cell lines when compared to FK228.

Original language	English
Pages (from-to)	538-542
Number of pages	5
Journal	MedChemComm
Volume	10
Issue number	4
DOIs	https://doi.org/10.1039/c9md00060g
State	Published - 2019

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title = "Origin and bioactivities of thiosulfinated FK228",

abstract = "During a large laboratory-scale purification of FK228 from the fermentation broth of Burkholderia thailandensis MSMB43, a small amount of thiosulfinated FK228 (TS-FK228) was unexpectedly purified only after the broth was mixed with silica gel. Evidence supports the postulations that TS-FK228 was derived from FK228 through spontaneous chemical reaction with silica gel, and TS-FK228 existed as two isomers 1 and 2. TS-FK228 demonstrated similar inhibitory activity and profile against human class I histone deacetylases but exhibited a much higher antiproliferative activity against representative human cancer cell lines when compared to FK228.",

author = "Xiangyang Liu and Currens, {Grant C.} and Liang Xue and Cheng, {Yi Qiang}",

note = "Funding Information: This work was supported in parts by an NIH/NCI grant R01 CA152212 and by institutional funds from the University of North Texas Health Science Center. Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

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doi = "10.1039/c9md00060g",

language = "English",

volume = "10",

pages = "538--542",

journal = "MedChemComm",

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T1 - Origin and bioactivities of thiosulfinated FK228

AU - Liu, Xiangyang

AU - Currens, Grant C.

AU - Xue, Liang

AU - Cheng, Yi Qiang

N1 - Funding Information: This work was supported in parts by an NIH/NCI grant R01 CA152212 and by institutional funds from the University of North Texas Health Science Center. Publisher Copyright: © 2019 The Royal Society of Chemistry.

PY - 2019

Y1 - 2019

N2 - During a large laboratory-scale purification of FK228 from the fermentation broth of Burkholderia thailandensis MSMB43, a small amount of thiosulfinated FK228 (TS-FK228) was unexpectedly purified only after the broth was mixed with silica gel. Evidence supports the postulations that TS-FK228 was derived from FK228 through spontaneous chemical reaction with silica gel, and TS-FK228 existed as two isomers 1 and 2. TS-FK228 demonstrated similar inhibitory activity and profile against human class I histone deacetylases but exhibited a much higher antiproliferative activity against representative human cancer cell lines when compared to FK228.

AB - During a large laboratory-scale purification of FK228 from the fermentation broth of Burkholderia thailandensis MSMB43, a small amount of thiosulfinated FK228 (TS-FK228) was unexpectedly purified only after the broth was mixed with silica gel. Evidence supports the postulations that TS-FK228 was derived from FK228 through spontaneous chemical reaction with silica gel, and TS-FK228 existed as two isomers 1 and 2. TS-FK228 demonstrated similar inhibitory activity and profile against human class I histone deacetylases but exhibited a much higher antiproliferative activity against representative human cancer cell lines when compared to FK228.

UR - http://www.scopus.com/inward/record.url?scp=85064625232&partnerID=8YFLogxK

U2 - 10.1039/c9md00060g

DO - 10.1039/c9md00060g

M3 - Article

AN - SCOPUS:85064625232

SN - 2040-2503

VL - 10

SP - 538

EP - 542

JO - MedChemComm

JF - MedChemComm

IS - 4

ER -

Origin and bioactivities of thiosulfinated FK228

Abstract

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