Oral polio vaccine. Effect of booster vaccination one to 14 years after primary series

J. W. Bass, S. B. Halstead, G. W. Fischer, J. K. Podgore, John Podgore

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Abstract

The authors studied the persistence of antibody after vaccination and the response to booster revaccination with trivalent oral polio vaccine (TOPV) administered at varied intervals after the primary series in a large group of children. Decline in antibody was related to intervals since last vaccination, and not to sex, age, age at primary vaccination, or type and number of previous administrations. Geometric mean titers of neutralizing antibody were 11.3 for type 1 and 8.0 for types 2 and 3 poliovirus when vaccine had been given the previous year, declining to 3.2, 3.0, and 2.1 for types 1, 2, and 3 after nine years. Most children with an initial titer of 4 or less responded to revaccination with a fourfold or greater increase in titer of IgG. Geometric mean titers for all three types of polio dropped to this level when last TOPV administration had been five to six years or more.

Original languageEnglish
Pages (from-to)2252-2255
Number of pages4
JournalJournal of the American Medical Association
Volume239
Issue number21
DOIs
StatePublished - 1 Dec 1978

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Poliomyelitis
Secondary Immunization
Vaccination
Vaccines
Poliovirus Vaccines
Antibodies
Neutralizing Antibodies
Immunoglobulin G

Cite this

Bass, J. W. ; Halstead, S. B. ; Fischer, G. W. ; Podgore, J. K. ; Podgore, John. / Oral polio vaccine. Effect of booster vaccination one to 14 years after primary series. In: Journal of the American Medical Association. 1978 ; Vol. 239, No. 21. pp. 2252-2255.
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Oral polio vaccine. Effect of booster vaccination one to 14 years after primary series. / Bass, J. W.; Halstead, S. B.; Fischer, G. W.; Podgore, J. K.; Podgore, John.

In: Journal of the American Medical Association, Vol. 239, No. 21, 01.12.1978, p. 2252-2255.

Research output: Contribution to journalArticleResearchpeer-review

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