Oral Immunotherapy with Human Secretory Immunoglobulin A Improves Survival in the Hamster Model of Clostridioides difficile Infection

Estelle F. Chiari; William Weiss; Michael R. Simon; Stephan T. Kiessig; Mark Pulse; Stephen C. Brown; Hanne R. Gerding; Maurice Mandago; Karina Gisch; Christoph Von Eichel-Streiber

doi:10.1093/infdis/jiab087

Oral Immunotherapy with Human Secretory Immunoglobulin A Improves Survival in the Hamster Model of Clostridioides difficile Infection

Estelle F. Chiari, William Weiss, Michael R. Simon, Stephan T. Kiessig, Mark Pulse, Stephen C. Brown, Hanne R. Gerding, Maurice Mandago, Karina Gisch, Christoph Von Eichel-Streiber

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4 Scopus citations

Abstract

Coadministration of human secretory IgA (sIgA) together with subtherapeutic vancomycin enhanced survival in the Clostridioides difficile infection (CDI) hamster model. Vancomycin (5 or 10 mg/kg × 5 days) plus healthy donor plasma sIgA/monomeric IgA (TID × 21 days) or hyperimmune sIgA/monomeric IgA (BID × 13 days) enhanced survival. Survival was improved compared to vancomycin alone, P =. 018 and. 039 by log-rank Mantel-Cox, for healthy and hyperimmune sIgA, respectively. Passive immunization with sIgA (recombinant human secretory component plus IgA dimer/polymer from pooled human plasma) can be administered orally and prevents death in a partially treated CDI hamster model.

Original language	English
Pages (from-to)	1394-1397
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	224
Issue number	8
DOIs	https://doi.org/10.1093/infdis/jiab087
State	Published - 15 Oct 2021

Keywords

Clostridioides difficile infection
immunotherapy
secretory IgA

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Chiari, E. F., Weiss, W., Simon, M. R., Kiessig, S. T., Pulse, M., Brown, S. C., Gerding, H. R., Mandago, M., Gisch, K., & Von Eichel-Streiber, C. (2021). Oral Immunotherapy with Human Secretory Immunoglobulin A Improves Survival in the Hamster Model of Clostridioides difficile Infection. Journal of Infectious Diseases, 224(8), 1394-1397. https://doi.org/10.1093/infdis/jiab087

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title = "Oral Immunotherapy with Human Secretory Immunoglobulin A Improves Survival in the Hamster Model of Clostridioides difficile Infection",

abstract = "Coadministration of human secretory IgA (sIgA) together with subtherapeutic vancomycin enhanced survival in the Clostridioides difficile infection (CDI) hamster model. Vancomycin (5 or 10 mg/kg × 5 days) plus healthy donor plasma sIgA/monomeric IgA (TID × 21 days) or hyperimmune sIgA/monomeric IgA (BID × 13 days) enhanced survival. Survival was improved compared to vancomycin alone, P =. 018 and. 039 by log-rank Mantel-Cox, for healthy and hyperimmune sIgA, respectively. Passive immunization with sIgA (recombinant human secretory component plus IgA dimer/polymer from pooled human plasma) can be administered orally and prevents death in a partially treated CDI hamster model.",

keywords = "Clostridioides difficile infection, immunotherapy, secretory IgA",

author = "Chiari, {Estelle F.} and William Weiss and Simon, {Michael R.} and Kiessig, {Stephan T.} and Mark Pulse and Brown, {Stephen C.} and Gerding, {Hanne R.} and Maurice Mandago and Karina Gisch and {Von Eichel-Streiber}, Christoph",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",

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doi = "10.1093/infdis/jiab087",

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Chiari, EF, Weiss, W, Simon, MR, Kiessig, ST, Pulse, M, Brown, SC, Gerding, HR, Mandago, M, Gisch, K & Von Eichel-Streiber, C 2021, 'Oral Immunotherapy with Human Secretory Immunoglobulin A Improves Survival in the Hamster Model of Clostridioides difficile Infection', Journal of Infectious Diseases, vol. 224, no. 8, pp. 1394-1397. https://doi.org/10.1093/infdis/jiab087

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T1 - Oral Immunotherapy with Human Secretory Immunoglobulin A Improves Survival in the Hamster Model of Clostridioides difficile Infection

AU - Chiari, Estelle F.

AU - Weiss, William

AU - Simon, Michael R.

AU - Kiessig, Stephan T.

AU - Pulse, Mark

AU - Brown, Stephen C.

AU - Gerding, Hanne R.

AU - Mandago, Maurice

AU - Gisch, Karina

AU - Von Eichel-Streiber, Christoph

N1 - Publisher Copyright: © 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2021/10/15

Y1 - 2021/10/15

N2 - Coadministration of human secretory IgA (sIgA) together with subtherapeutic vancomycin enhanced survival in the Clostridioides difficile infection (CDI) hamster model. Vancomycin (5 or 10 mg/kg × 5 days) plus healthy donor plasma sIgA/monomeric IgA (TID × 21 days) or hyperimmune sIgA/monomeric IgA (BID × 13 days) enhanced survival. Survival was improved compared to vancomycin alone, P =. 018 and. 039 by log-rank Mantel-Cox, for healthy and hyperimmune sIgA, respectively. Passive immunization with sIgA (recombinant human secretory component plus IgA dimer/polymer from pooled human plasma) can be administered orally and prevents death in a partially treated CDI hamster model.

AB - Coadministration of human secretory IgA (sIgA) together with subtherapeutic vancomycin enhanced survival in the Clostridioides difficile infection (CDI) hamster model. Vancomycin (5 or 10 mg/kg × 5 days) plus healthy donor plasma sIgA/monomeric IgA (TID × 21 days) or hyperimmune sIgA/monomeric IgA (BID × 13 days) enhanced survival. Survival was improved compared to vancomycin alone, P =. 018 and. 039 by log-rank Mantel-Cox, for healthy and hyperimmune sIgA, respectively. Passive immunization with sIgA (recombinant human secretory component plus IgA dimer/polymer from pooled human plasma) can be administered orally and prevents death in a partially treated CDI hamster model.

KW - Clostridioides difficile infection

KW - immunotherapy

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SN - 0022-1899

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JF - Journal of Infectious Diseases

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ER -

Oral Immunotherapy with Human Secretory Immunoglobulin A Improves Survival in the Hamster Model of Clostridioides difficile Infection

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