Abstract
Coadministration of human secretory IgA (sIgA) together with subtherapeutic vancomycin enhanced survival in the Clostridioides difficile infection (CDI) hamster model. Vancomycin (5 or 10 mg/kg × 5 days) plus healthy donor plasma sIgA/monomeric IgA (TID × 21 days) or hyperimmune sIgA/monomeric IgA (BID × 13 days) enhanced survival. Survival was improved compared to vancomycin alone, P =. 018 and. 039 by log-rank Mantel-Cox, for healthy and hyperimmune sIgA, respectively. Passive immunization with sIgA (recombinant human secretory component plus IgA dimer/polymer from pooled human plasma) can be administered orally and prevents death in a partially treated CDI hamster model.
Original language | English |
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Pages (from-to) | 1394-1397 |
Number of pages | 4 |
Journal | Journal of Infectious Diseases |
Volume | 224 |
Issue number | 8 |
DOIs | |
State | Published - 15 Oct 2021 |
Keywords
- Clostridioides difficile infection
- immunotherapy
- secretory IgA