Open-label nefazodone in patients with a major depressive episode and alcohol dependence

E. Sherwood Brown, Leonardo Bobadilla, Vicki A. Nejtek, Dana Perantie, Harminder Dhillon, Alan Frol

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Purpose: Major depressive disorder (MDD) and alcohol dependence (AD) frequently occur together. However, MDD clinical trials generally exclude patients with alcohol-related disorders. General Methods: A 12-week, open-label trial of nefazodone in a group of people (n=13) with both a current major depressive episode and current AD was conducted to examine the effect of this antidepressant on depressive symptoms, alcohol use, and cognition. Findings: Scores on the Hamilton Rating Scale for Depression (HRSD) and Hamilton Rating Scale for Anxiety (HRSA) significantly decreased from baseline to exit. In addition, significant reduction in alcohol craving, drinks/week, and days of alcohol use/week was found. Scores on the Rey Auditory Verbal Learning Test (RAVLT) did not significantly improve during the study. Changes in mood/anxiety and memory did not correlate with changes in alcohol use. Conclusions: Thus, nefazodone therapy was associated with improvement in mood/anxiety and alcohol use, which seem to be independent of each other in this patient sample. However, declarative memory, which was low average at baseline, did not show statistically significant improvement during the 12 weeks of the study.

Original languageEnglish
Pages (from-to)681-685
Number of pages5
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume27
Issue number4
DOIs
StatePublished - Jun 2003

Keywords

  • Alcohol dependence
  • Antidepressant
  • Major depressive disorder
  • Nefazodone

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