TY - JOUR
T1 - One-way generalization of clonidine to the discriminative stimulus produced by cocaine
AU - Wood, Douglas M.
AU - Lal, Harbans
AU - Yaden, Senka
AU - Emmett-Oglesby, M. W.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1985/10
Y1 - 1985/10
N2 - Rats were trained to discriminate the stimulus properties of either cocaine or clonidine using a food reinforced two-lever choice paradigm. After training, cocaine was generalized to the cocaine lever in a dose-dependent manner, and clonidine was generalized to the clonidine lever in a dose-dependent manner. Yohimbine, an alpha-2 antagonist, blocked the clonidine stimulus but not the cocaine stimulus. Cocaine was not generalized to the clonidine stimulus; however, clonidine was generalized to the cocaine stimulus, and this generalization was blocked by yohimbine. The one-way generalization of clonidine to cocaine suggests that clonidine has at least two discrete stimulus components: a major component that is not cocaine-like, and a minor component that can be detected by cocaine-trained subjects. In addition, the yohimbine blockade data suggest that both components of the clonidine stimulus are mediated via alpha-2 receptors.
AB - Rats were trained to discriminate the stimulus properties of either cocaine or clonidine using a food reinforced two-lever choice paradigm. After training, cocaine was generalized to the cocaine lever in a dose-dependent manner, and clonidine was generalized to the clonidine lever in a dose-dependent manner. Yohimbine, an alpha-2 antagonist, blocked the clonidine stimulus but not the cocaine stimulus. Cocaine was not generalized to the clonidine stimulus; however, clonidine was generalized to the cocaine stimulus, and this generalization was blocked by yohimbine. The one-way generalization of clonidine to cocaine suggests that clonidine has at least two discrete stimulus components: a major component that is not cocaine-like, and a minor component that can be detected by cocaine-trained subjects. In addition, the yohimbine blockade data suggest that both components of the clonidine stimulus are mediated via alpha-2 receptors.
KW - Alpha-2 receptors
KW - Clonidine
KW - Cocaine
KW - Discriminative stimulus
KW - Yohimbine
UR - http://www.scopus.com/inward/record.url?scp=0022394933&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(85)90414-9
DO - 10.1016/0091-3057(85)90414-9
M3 - Article
C2 - 2999832
AN - SCOPUS:0022394933
SN - 0091-3057
VL - 23
SP - 529
EP - 533
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 4
ER -