Oncogenic activation in prostate cancer progression and metastasis: Molecular insights and future challenges

Subhamoy Dasgupta, Srinivasa Srinidhi, Jamboor K. Vishwanatha

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Prostate cancer is a leading cause of death among men in the United States, and currently early diagnosis and appropriate treatment remain key approaches for patient care. Molecularly prostate cancer cells carry multiple perturbations that generate malignant phenotype capable of uncontrolled growth, survival, and invasion-metastasis to other organs. These alterations are acquired both by genetic and epigenetic changes in tumor cells resulting in the activation of growth factor receptors, signaling proteins, kinases, transcription factors and coregulators, and multiple proteases required for the progression of the disease. Recent advances provide novel insights into the molecular functions of these oncogenic activators, implicating potential therapeutic targeting opportunities for the treatment of prostate cancer.

Original languageEnglish
Article number4
JournalJournal of Carcinogenesis
Volume11
DOIs
StatePublished - 1 Dec 2012

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Prostatic Neoplasms
Neoplasm Metastasis
Activator Appliances
Growth Factor Receptors
Epigenomics
Protein Kinases
Disease Progression
Early Diagnosis
Cause of Death
Patient Care
Peptide Hydrolases
Transcription Factors
Therapeutics
Phenotype
Survival
Growth
Neoplasms

Keywords

  • growth factor receptors
  • oncogene
  • PI3K-Akt
  • Prostate cancer
  • proteases
  • signaling pathways

Cite this

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Oncogenic activation in prostate cancer progression and metastasis : Molecular insights and future challenges. / Dasgupta, Subhamoy; Srinidhi, Srinivasa; Vishwanatha, Jamboor K.

In: Journal of Carcinogenesis, Vol. 11, 4, 01.12.2012.

Research output: Contribution to journalArticle

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