TY - JOUR
T1 - Oncogenic activation in prostate cancer progression and metastasis
T2 - Molecular insights and future challenges
AU - Dasgupta, Subhamoy
AU - Srinidhi, Srinivasa
AU - Vishwanatha, Jamboor
PY - 2012
Y1 - 2012
N2 - Prostate cancer is a leading cause of death among men in the United States, and currently early diagnosis and appropriate treatment remain key approaches for patient care. Molecularly prostate cancer cells carry multiple perturbations that generate malignant phenotype capable of uncontrolled growth, survival, and invasion-metastasis to other organs. These alterations are acquired both by genetic and epigenetic changes in tumor cells resulting in the activation of growth factor receptors, signaling proteins, kinases, transcription factors and coregulators, and multiple proteases required for the progression of the disease. Recent advances provide novel insights into the molecular functions of these oncogenic activators, implicating potential therapeutic targeting opportunities for the treatment of prostate cancer.
AB - Prostate cancer is a leading cause of death among men in the United States, and currently early diagnosis and appropriate treatment remain key approaches for patient care. Molecularly prostate cancer cells carry multiple perturbations that generate malignant phenotype capable of uncontrolled growth, survival, and invasion-metastasis to other organs. These alterations are acquired both by genetic and epigenetic changes in tumor cells resulting in the activation of growth factor receptors, signaling proteins, kinases, transcription factors and coregulators, and multiple proteases required for the progression of the disease. Recent advances provide novel insights into the molecular functions of these oncogenic activators, implicating potential therapeutic targeting opportunities for the treatment of prostate cancer.
KW - PI3K-Akt
KW - Prostate cancer
KW - growth factor receptors
KW - oncogene
KW - proteases
KW - signaling pathways
UR - http://www.scopus.com/inward/record.url?scp=84869072462&partnerID=8YFLogxK
U2 - 10.4103/1477-3163.93001
DO - 10.4103/1477-3163.93001
M3 - Article
C2 - 22438770
AN - SCOPUS:84869072462
SN - 0974-6773
VL - 11
JO - Journal of Carcinogenesis
JF - Journal of Carcinogenesis
M1 - 4
ER -