Oncogenic activation in prostate cancer progression and metastasis: Molecular insights and future challenges

Subhamoy Dasgupta, Srinivasa Srinidhi, Jamboor Vishwanatha

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Prostate cancer is a leading cause of death among men in the United States, and currently early diagnosis and appropriate treatment remain key approaches for patient care. Molecularly prostate cancer cells carry multiple perturbations that generate malignant phenotype capable of uncontrolled growth, survival, and invasion-metastasis to other organs. These alterations are acquired both by genetic and epigenetic changes in tumor cells resulting in the activation of growth factor receptors, signaling proteins, kinases, transcription factors and coregulators, and multiple proteases required for the progression of the disease. Recent advances provide novel insights into the molecular functions of these oncogenic activators, implicating potential therapeutic targeting opportunities for the treatment of prostate cancer.

Original languageEnglish
Article number4
JournalJournal of Carcinogenesis
Volume11
DOIs
StatePublished - 2012

Keywords

  • PI3K-Akt
  • Prostate cancer
  • growth factor receptors
  • oncogene
  • proteases
  • signaling pathways

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