On allele frequency computation from DNA typing data

Ranajit Chakraborty, Li An, Yixi Zhong, M. R. Srinivasan, Bruce Budowle

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Forensic applications of DNA typing data require the estimation of the frequencies of all observed alleles, which is currently done by a fixed set of groupings (binning) of alleles in a database. Recently it's validity has been questioned on the ground that when a DNA fragment size is close to a bin boundary, the frequencies of all adjacent bins should be added. On the contrary, the current forensic database indicates that when the match window of a DNA fragment overlaps 2 bins, it is enough to consider the bin with the larger frequency, and this never underestimates the frequency within the match interval with the current choice of fixed-bin widths. On average, the current fixed-bin procedure yields an allele frequency at least 2-fold higher than that of a floating-bin.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalInternational journal of legal medicine
Volume106
Issue number2
DOIs
StatePublished - 1 Mar 1993

Keywords

  • Allele frequency computation
  • Fixed bin
  • Floating bin

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