Abstract
Forensic applications of DNA typing data require the estimation of the frequencies of all observed alleles, which is currently done by a fixed set of groupings (binning) of alleles in a database. Recently it's validity has been questioned on the ground that when a DNA fragment size is close to a bin boundary, the frequencies of all adjacent bins should be added. On the contrary, the current forensic database indicates that when the match window of a DNA fragment overlaps 2 bins, it is enough to consider the bin with the larger frequency, and this never underestimates the frequency within the match interval with the current choice of fixed-bin widths. On average, the current fixed-bin procedure yields an allele frequency at least 2-fold higher than that of a floating-bin.
Original language | English |
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Pages (from-to) | 103-106 |
Number of pages | 4 |
Journal | International journal of legal medicine |
Volume | 106 |
Issue number | 2 |
DOIs | |
State | Published - Mar 1993 |
Keywords
- Allele frequency computation
- Fixed bin
- Floating bin