Odorant Item Specific Olfactory Identification Deficit May Differentiate Alzheimer Disease From Aging

Texas Alzheimer's Research, Care Consortium

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: To explore whether the ability to recognize specific odorant items is differentially affected in aging versus Alzheimer disease (AD); to refine olfactory identification deficit (OID) as a biomarker of prodromal and early AD. Design: Prospective multicenter cross-sectional study with a longitudinal arm. Setting: Outpatient memory diagnostic clinics in New York and Texas. Participants: Adults aged 65 and older with amnestic mild cognitive impairment (aMCI) and AD and healthy aging (HA) subjects in the comparison group. Measurements: Participants completed the University of Pennsylvania Smell Identification Test (UPSIT) and neuropsychological testing. AD-associated odorants (AD-10) were selected based on a model of ordinal logistic regression. Age-associated odorants (Age-10) were identified using a linear model. Results: For the 841 participants (234 HA, 192 aMCI, 415 AD), AD-10 was superior to Age-10 in separating HA and AD. AD-10 was associated with a more widespread cognitive deficit across multiple domains, in contrast to Age-10. The disease- and age-associated odorants clustered separately in age and AD. AD-10 predicted conversion from aMCI to AD. Conclusions: Nonoverlapping UPSIT items were identified that were individually associated with age and disease. Despite a modest predictive value of the AD-specific items for conversion to AD, the AD-specific items may be useful in enriching samples to better identify those at risk for AD. Further studies are needed with monomolecular and unilateral stimulation and orthogonal biomarker validation to further refine disease- and age-associated signals.

Original languageEnglish
Pages (from-to)835-846
Number of pages12
JournalAmerican Journal of Geriatric Psychiatry
Volume26
Issue number8
DOIs
StatePublished - Aug 2018

Fingerprint

Alzheimer Disease
Smell
Odorants
Healthy Volunteers
Biomarkers
Aptitude
Neuropsychological Tests
Linear Models
Outpatients
Cross-Sectional Studies
Logistic Models
Alzheimer Disease 10

Keywords

  • Alzheimer disease
  • cognitive aging
  • mild cognitive impairment
  • olfactory identification
  • smell

Cite this

@article{4ede369c3ab1419e92a6b5bec25e2b70,
title = "Odorant Item Specific Olfactory Identification Deficit May Differentiate Alzheimer Disease From Aging",
abstract = "Objectives: To explore whether the ability to recognize specific odorant items is differentially affected in aging versus Alzheimer disease (AD); to refine olfactory identification deficit (OID) as a biomarker of prodromal and early AD. Design: Prospective multicenter cross-sectional study with a longitudinal arm. Setting: Outpatient memory diagnostic clinics in New York and Texas. Participants: Adults aged 65 and older with amnestic mild cognitive impairment (aMCI) and AD and healthy aging (HA) subjects in the comparison group. Measurements: Participants completed the University of Pennsylvania Smell Identification Test (UPSIT) and neuropsychological testing. AD-associated odorants (AD-10) were selected based on a model of ordinal logistic regression. Age-associated odorants (Age-10) were identified using a linear model. Results: For the 841 participants (234 HA, 192 aMCI, 415 AD), AD-10 was superior to Age-10 in separating HA and AD. AD-10 was associated with a more widespread cognitive deficit across multiple domains, in contrast to Age-10. The disease- and age-associated odorants clustered separately in age and AD. AD-10 predicted conversion from aMCI to AD. Conclusions: Nonoverlapping UPSIT items were identified that were individually associated with age and disease. Despite a modest predictive value of the AD-specific items for conversion to AD, the AD-specific items may be useful in enriching samples to better identify those at risk for AD. Further studies are needed with monomolecular and unilateral stimulation and orthogonal biomarker validation to further refine disease- and age-associated signals.",
keywords = "Alzheimer disease, cognitive aging, mild cognitive impairment, olfactory identification, smell",
author = "{Texas Alzheimer's Research, Care Consortium} and Woodward, {Matthew R.} and Hafeez, {Muhammad Ubaid} and Qianya Qi and Ahmed Riaz and Benedict, {Ralph H.B.} and Li Yan and Kinga Szigeti and Valory Pavlik and Paul Massman and Eveleen Darby and Monica Rodriguear and {Khaleeq Ansari}, Aisha and DeToledo, {John C.} and Hemachandra Reddy and Henrick Wilms and Kim Johnson and Victoria Perez and Thomas Fairchild and Janice Knebl and O'Bryant, {Sid E.} and Hall, {James R.} and Leigh Johnson and Barber, {Robert C.} and Douglas Mains and Lisa Alvarez and Munro Cullum and Roger Rosenberg and Benjamin Williams and Mary Quiceno and Joan Reisch and Hynan, {Linda S.} and Ryan Huebinger and Janet Smith and Trung Nguyen and Donald Royall and Raymond Palmer and Marsha Polk and Alan Stevens and Marcia Ory and David Paydarfar and John Bertelson and Martin Woon and Gayle Ayres and Alyssa Aguirre and Wilhelmsen, {Kirk C.} and Tilson, {Jeffrey L.}",
year = "2018",
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pages = "835--846",
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}

Odorant Item Specific Olfactory Identification Deficit May Differentiate Alzheimer Disease From Aging. / Texas Alzheimer's Research, Care Consortium.

In: American Journal of Geriatric Psychiatry, Vol. 26, No. 8, 08.2018, p. 835-846.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Odorant Item Specific Olfactory Identification Deficit May Differentiate Alzheimer Disease From Aging

AU - Texas Alzheimer's Research, Care Consortium

AU - Woodward, Matthew R.

AU - Hafeez, Muhammad Ubaid

AU - Qi, Qianya

AU - Riaz, Ahmed

AU - Benedict, Ralph H.B.

AU - Yan, Li

AU - Szigeti, Kinga

AU - Pavlik, Valory

AU - Massman, Paul

AU - Darby, Eveleen

AU - Rodriguear, Monica

AU - Khaleeq Ansari, Aisha

AU - DeToledo, John C.

AU - Reddy, Hemachandra

AU - Wilms, Henrick

AU - Johnson, Kim

AU - Perez, Victoria

AU - Fairchild, Thomas

AU - Knebl, Janice

AU - O'Bryant, Sid E.

AU - Hall, James R.

AU - Johnson, Leigh

AU - Barber, Robert C.

AU - Mains, Douglas

AU - Alvarez, Lisa

AU - Cullum, Munro

AU - Rosenberg, Roger

AU - Williams, Benjamin

AU - Quiceno, Mary

AU - Reisch, Joan

AU - Hynan, Linda S.

AU - Huebinger, Ryan

AU - Smith, Janet

AU - Nguyen, Trung

AU - Royall, Donald

AU - Palmer, Raymond

AU - Polk, Marsha

AU - Stevens, Alan

AU - Ory, Marcia

AU - Paydarfar, David

AU - Bertelson, John

AU - Woon, Martin

AU - Ayres, Gayle

AU - Aguirre, Alyssa

AU - Wilhelmsen, Kirk C.

AU - Tilson, Jeffrey L.

PY - 2018/8

Y1 - 2018/8

N2 - Objectives: To explore whether the ability to recognize specific odorant items is differentially affected in aging versus Alzheimer disease (AD); to refine olfactory identification deficit (OID) as a biomarker of prodromal and early AD. Design: Prospective multicenter cross-sectional study with a longitudinal arm. Setting: Outpatient memory diagnostic clinics in New York and Texas. Participants: Adults aged 65 and older with amnestic mild cognitive impairment (aMCI) and AD and healthy aging (HA) subjects in the comparison group. Measurements: Participants completed the University of Pennsylvania Smell Identification Test (UPSIT) and neuropsychological testing. AD-associated odorants (AD-10) were selected based on a model of ordinal logistic regression. Age-associated odorants (Age-10) were identified using a linear model. Results: For the 841 participants (234 HA, 192 aMCI, 415 AD), AD-10 was superior to Age-10 in separating HA and AD. AD-10 was associated with a more widespread cognitive deficit across multiple domains, in contrast to Age-10. The disease- and age-associated odorants clustered separately in age and AD. AD-10 predicted conversion from aMCI to AD. Conclusions: Nonoverlapping UPSIT items were identified that were individually associated with age and disease. Despite a modest predictive value of the AD-specific items for conversion to AD, the AD-specific items may be useful in enriching samples to better identify those at risk for AD. Further studies are needed with monomolecular and unilateral stimulation and orthogonal biomarker validation to further refine disease- and age-associated signals.

AB - Objectives: To explore whether the ability to recognize specific odorant items is differentially affected in aging versus Alzheimer disease (AD); to refine olfactory identification deficit (OID) as a biomarker of prodromal and early AD. Design: Prospective multicenter cross-sectional study with a longitudinal arm. Setting: Outpatient memory diagnostic clinics in New York and Texas. Participants: Adults aged 65 and older with amnestic mild cognitive impairment (aMCI) and AD and healthy aging (HA) subjects in the comparison group. Measurements: Participants completed the University of Pennsylvania Smell Identification Test (UPSIT) and neuropsychological testing. AD-associated odorants (AD-10) were selected based on a model of ordinal logistic regression. Age-associated odorants (Age-10) were identified using a linear model. Results: For the 841 participants (234 HA, 192 aMCI, 415 AD), AD-10 was superior to Age-10 in separating HA and AD. AD-10 was associated with a more widespread cognitive deficit across multiple domains, in contrast to Age-10. The disease- and age-associated odorants clustered separately in age and AD. AD-10 predicted conversion from aMCI to AD. Conclusions: Nonoverlapping UPSIT items were identified that were individually associated with age and disease. Despite a modest predictive value of the AD-specific items for conversion to AD, the AD-specific items may be useful in enriching samples to better identify those at risk for AD. Further studies are needed with monomolecular and unilateral stimulation and orthogonal biomarker validation to further refine disease- and age-associated signals.

KW - Alzheimer disease

KW - cognitive aging

KW - mild cognitive impairment

KW - olfactory identification

KW - smell

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VL - 26

SP - 835

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JO - American Journal of Geriatric Psychiatry

JF - American Journal of Geriatric Psychiatry

SN - 1064-7481

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