TY - JOUR
T1 - Ocular manifestations and concepts of systemic vasculitides
AU - Perez, Victor L.
AU - Chavala, Sai H.
AU - Ahmed, Muna
AU - Chu, David
AU - Zafirakis, Panos
AU - Baltatzis, Stefanos
AU - Ocampo, Vicente
AU - Foster, C. Stephen
PY - 2004/7
Y1 - 2004/7
N2 - Vasculitic disorders are relatively rare. Their etiology and pathophysiology remain enigmatic, leading to confusing nomenclature and multiple classification schemes. Untreated vasculitis can be fatal. Early diagnosis is the key to successful treatment and better prognosis. However, early diagnosis can be difficult; vasculitic conditions usually present with non-specific symptoms for a long period before clinically overt manifestations occur. Ophthalmologists should be familiar with the ocular manifestations of the vasculitic disorders because they may not only be sight-threatening, but more importantly could be the presenting manifestations of active, potentially lethal systemic disease. This review summarizes clinical and ocular manifestations of systemic vasculitic disorders. Furthermore, it discusses general concepts in diagnosis and treatment of these diseases in an effort to provide a practical framework for the ophthalmologist evaluating patients with vasculitis.
AB - Vasculitic disorders are relatively rare. Their etiology and pathophysiology remain enigmatic, leading to confusing nomenclature and multiple classification schemes. Untreated vasculitis can be fatal. Early diagnosis is the key to successful treatment and better prognosis. However, early diagnosis can be difficult; vasculitic conditions usually present with non-specific symptoms for a long period before clinically overt manifestations occur. Ophthalmologists should be familiar with the ocular manifestations of the vasculitic disorders because they may not only be sight-threatening, but more importantly could be the presenting manifestations of active, potentially lethal systemic disease. This review summarizes clinical and ocular manifestations of systemic vasculitic disorders. Furthermore, it discusses general concepts in diagnosis and treatment of these diseases in an effort to provide a practical framework for the ophthalmologist evaluating patients with vasculitis.
KW - Churg-Strauss syndrome
KW - Henoch-Schönlein purpura
KW - Kawasaki disease
KW - Takayasu's arteritis
KW - cutaneous leukocytoclastic angiitis
KW - giant cell arteritis
KW - microscopic polyangiitis
KW - ocular manifestations
KW - polyarteritis nodosa
KW - primary vasculitis
UR - http://www.scopus.com/inward/record.url?scp=3042660255&partnerID=8YFLogxK
U2 - 10.1016/j.survophthal.2004.04.008
DO - 10.1016/j.survophthal.2004.04.008
M3 - Review article
C2 - 15231396
AN - SCOPUS:3042660255
SN - 0039-6257
VL - 49
SP - 399
EP - 418
JO - Survey of Ophthalmology
JF - Survey of Ophthalmology
IS - 4
ER -