Abstract
Uveoretinitis induced in Lewis rats by foot pad injections of retinal soluble (S) antigen is a model system used to study the immunopathogenesis of the autoimmune uveoretinitides in which delayed hypersensitivity plays a dominant role. Since down-regulation of delayed hypersensitivity can be achieved by injection of antigens into the anterior chamber of the eye, we have examined the potential of intracameral S antigen to mitigate experimental autoimmune uveitis. The results of these studies reveal that pretreatment of Lewis rats with S antigen injected into the anterior chamber markedly reduces the incidence and expression of experimental autoimmune uveitis.
| Original language | English |
|---|---|
| Pages (from-to) | 772-774 |
| Number of pages | 3 |
| Journal | Investigative Ophthalmology and Visual Science |
| Volume | 30 |
| Issue number | 4 |
| State | Published - 1989 |