Ocular injection of retinal S antigen: Suppression of autoimmune uveitis

K. Mizuno, A. F. Clark, J. W. Streilein

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Uveoretinitis induced in Lewis rats by foot pad injections of retinal soluble (S) antigen is a model system used to study the immunopathogenesis of the autoimmune uveoretinitides in which delayed hypersensitivity plays a dominant role. Since down-regulation of delayed hypersensitivity can be achieved by injection of antigens into the anterior chamber of the eye, we have examined the potential of intracameral S antigen to mitigate experimental autoimmune uveitis. The results of these studies reveal that pretreatment of Lewis rats with S antigen injected into the anterior chamber markedly reduces the incidence and expression of experimental autoimmune uveitis.

Original languageEnglish
Pages (from-to)772-774
Number of pages3
JournalInvestigative Ophthalmology and Visual Science
Issue number4
StatePublished - 1989


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