Ocular hypotensive effects of lofexidine, an alpha2‐adrenoreceptor agonist

Edward E. Elko, Tung Tran, Harbans Lal, Thomas Yorio

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Abstract

The present study examines the ocular hypotensive efficacy end pupillary response of the alpha2‐adrenergic receptor agonists lofexidine and clonidine. The topical administration of lofexidine to rabbit eyes in concentrations ranging from 0.25 to 5%, produced a dosedependent bilateral reduction in intraocular pressure (IOP), with the contralateral (untreated) eye exhibiting a significantly greater reduction in IOP than the ipsilateral (treated) eye, particularly at the lower concentrations. The maximum decrease in IOP was observed at 60 min postdrug with the IOP recovering gradually to predrug values with time. Pupillary dilatation was observed only in the durg‐treated eye. Unlike lofexidine, clonidine had no effect on pupillalry diameter. Clonidine decreaed IOP predominantly in the untereated contralateral eye at doses ranging from 0.625% to 5%, whereas a significant ocular hypertensive effect of clonidine was noted at the 7.5% dose in the treated ipsilateral eye. The present data provide evidence that topically administered lofexidine lowers IOP in normotensive New Zealand White (NZW) rabbits.

Original languageEnglish
Pages (from-to)169-175
Number of pages7
JournalDrug Development Research
Volume14
Issue number2
DOIs
Publication statusPublished - 1988

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Keywords

  • antiglaucoma drugs
  • clonidine
  • intraocular pressure

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