TY - JOUR
T1 - Obesity-related increased γ' fibrinogen concentration in children and its reduction by a physical activity-based lifestyle intervention
T2 - A randomized controlled study
AU - Lovely, Rehana
AU - Hossain, Jobayer
AU - Ramsey, Jonathen P.
AU - Komakula, Venugopal
AU - George, Donald
AU - Farrell, David H.
AU - Balagopal, Prabhakaran
N1 - Funding Information:
P. B. is supported by Nemours Research Programs and the American Heart Association Scientist Development Grant Award . Oregon Health & Science University (OHSU) and D.F. have significant interest in Gamma Therapeutics, a company that may have commercial interest in this research and technology; this potential conflict of interest has been reviewed and managed by OHSU. The other authors declare no conflicts of interest.
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/8
Y1 - 2013/8
N2 - Objective: To determine if elevated plasma γ′-fibrinogen, typically involved in the formation of fibrinolysis-resistant clots, confers an increased risk for cardiovascular disease (CVD) and thrombosis in children as it does in adults. Although obesity-related hyperfibrinogenemia is frequently reported in children, the role of γ′ fibrinogen and its response to physical activity-based lifestyle are less clear in this population. Study design: In a randomized controlled 3-month physical activity-based lifestyle intervention, γ′ fibrinogen concentration was measured in 21 children (aged 14-18 years; Tanner stage > IV), including 15 in the obese group and 6 in the normal weight group, with body mass index percentiles for age and sex of >95 and <85, respectively. Results: The relationships between γ′ fibrinogen and other risk factors for CVD, such as markers of insulin resistance and subclinical inflammation, along with body composition (as measured by dual-energy X-ray absortiometry), were assessed before and after the intervention. γ′ fibrinogen concentration was higher in the obese group compared with the normal weight group (P <.05) and was correlated with other risk factors for CVD (adjusted R2 = 0.9; P <.05), and insulin emerged as the major predictor of γ′ fibrinogen. The intervention reduced γ′-fibrinogen concentration (P <.05). Conclusion: Our data reveal: (1) elevated γ′ fibrinogen concentrations in obese insulin-resistant children compared with normal lean controls; (2) a relationship between γ′ fibrinogen and other CVD risk factors; and (3) physical activity-induced reduction in γ′ fibrinogen in obese children.
AB - Objective: To determine if elevated plasma γ′-fibrinogen, typically involved in the formation of fibrinolysis-resistant clots, confers an increased risk for cardiovascular disease (CVD) and thrombosis in children as it does in adults. Although obesity-related hyperfibrinogenemia is frequently reported in children, the role of γ′ fibrinogen and its response to physical activity-based lifestyle are less clear in this population. Study design: In a randomized controlled 3-month physical activity-based lifestyle intervention, γ′ fibrinogen concentration was measured in 21 children (aged 14-18 years; Tanner stage > IV), including 15 in the obese group and 6 in the normal weight group, with body mass index percentiles for age and sex of >95 and <85, respectively. Results: The relationships between γ′ fibrinogen and other risk factors for CVD, such as markers of insulin resistance and subclinical inflammation, along with body composition (as measured by dual-energy X-ray absortiometry), were assessed before and after the intervention. γ′ fibrinogen concentration was higher in the obese group compared with the normal weight group (P <.05) and was correlated with other risk factors for CVD (adjusted R2 = 0.9; P <.05), and insulin emerged as the major predictor of γ′ fibrinogen. The intervention reduced γ′-fibrinogen concentration (P <.05). Conclusion: Our data reveal: (1) elevated γ′ fibrinogen concentrations in obese insulin-resistant children compared with normal lean controls; (2) a relationship between γ′ fibrinogen and other CVD risk factors; and (3) physical activity-induced reduction in γ′ fibrinogen in obese children.
KW - BMI
KW - BSA
KW - Body mass index
KW - Bovine serum albumin
KW - C-reactive protein
KW - CRP
KW - CVD
KW - Cardiovascular disease
KW - DEXA
KW - Dual-energy X-ray absorptiometry
KW - HOMA-IR
KW - Homeostasis model of assessment-insulin resistance
KW - IL
KW - Interleukin
KW - PBS
KW - Phosphate-buffered saline
UR - http://www.scopus.com/inward/record.url?scp=84880618613&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2013.01.004
DO - 10.1016/j.jpeds.2013.01.004
M3 - Article
C2 - 23415619
AN - SCOPUS:84880618613
SN - 0022-3476
VL - 163
SP - 333
EP - 338
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
IS - 2
ER -