Novel ether derivatives of mannopeptimycin glycopeptide antibiotic

Phaik Eng Sum; David How; Nancy Torres; Peter J. Petersen; Eileen B. Lenoy; William J. Weiss; Tarek S. Mansour

doi:10.1016/S0960-894X(03)00045-3

Novel ether derivatives of mannopeptimycin glycopeptide antibiotic

Phaik Eng Sum, David How, Nancy Torres, Peter J. Petersen, Eileen B. Lenoy, William J. Weiss, Tarek S. Mansour

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Novel ether derivatives of mannopeptimycin glycopeptide were synthesized to probe their SAR. Many of these derivatives exhibited potent antibacterial activity against methicillin resistant and vancomycin resistant strains. These ether derivatives were prepared via reductive ring cleavage of acetals to give a mixture of 6-O, 4-O, 3-O, and 2-O-ether isomers. Both 6-O-ether and 4-O-ether showed significantly enhanced antibacterial activity over the parent and the isovalerate esters.

Original language	English
Pages (from-to)	1151-1155
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	6
DOIs	https://doi.org/10.1016/S0960-894X(03)00045-3
State	Published - 24 Mar 2003

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AU - Sum, Phaik Eng

AU - How, David

AU - Torres, Nancy

AU - Petersen, Peter J.

AU - Lenoy, Eileen B.

AU - Weiss, William J.

AU - Mansour, Tarek S.

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AB - Novel ether derivatives of mannopeptimycin glycopeptide were synthesized to probe their SAR. Many of these derivatives exhibited potent antibacterial activity against methicillin resistant and vancomycin resistant strains. These ether derivatives were prepared via reductive ring cleavage of acetals to give a mixture of 6-O, 4-O, 3-O, and 2-O-ether isomers. Both 6-O-ether and 4-O-ether showed significantly enhanced antibacterial activity over the parent and the isovalerate esters.

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Novel ether derivatives of mannopeptimycin glycopeptide antibiotic

Abstract

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