Novel ether derivatives of mannopeptimycin glycopeptide antibiotic

Phaik Eng Sum, David How, Nancy Torres, Peter J. Petersen, Eileen B. Lenoy, William J. Weiss, Tarek S. Mansour

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Novel ether derivatives of mannopeptimycin glycopeptide were synthesized to probe their SAR. Many of these derivatives exhibited potent antibacterial activity against methicillin resistant and vancomycin resistant strains. These ether derivatives were prepared via reductive ring cleavage of acetals to give a mixture of 6-O, 4-O, 3-O, and 2-O-ether isomers. Both 6-O-ether and 4-O-ether showed significantly enhanced antibacterial activity over the parent and the isovalerate esters.

Original languageEnglish
Pages (from-to)1151-1155
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number6
DOIs
StatePublished - 24 Mar 2003

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