Abstract
A series of 8-substituted benzodifuran analogs was prepared and evaluated for 5-HT2A receptor binding and activation. Several compounds containing ether and ester functionality were found to be potent agonists. Topical ocular administration of 5, 18, and 25 effectively reduced intra-ocular pressure in the hypertensive cynomolgus monkey eye in the range of 25-37%.
Original language | English |
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Pages (from-to) | 2998-3002 |
Number of pages | 5 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 17 |
Issue number | 11 |
DOIs | |
State | Published - 1 Jun 2007 |
Keywords
- (R)-DOI
- 5-HT agonist
- Benzodifuran
- Glaucoma
- IOP
- Oxadiazole