TY - JOUR
T1 - Nonspecific lymphocyte responses in F344 and LEW rats
T2 - Susceptibility to murine respiratory mycoplasmosis and examination of cellular basis for strain differences
AU - Davis, Jerry K.
AU - Simecka, Jerry W.
AU - Williamson, Jo S.P.
AU - Ross, Suzanne E.
AU - Margaret Juliana, M.
AU - Thorp, Randall B.
AU - Cassell, Gail H.
PY - 1985
Y1 - 1985
N2 - Mycoplasma pulmonis produces a mitogen which may play a role in the pathogenesis of murine respiratory mycoplasmosis in rats. Since LEW rats are more susceptible to this disease than F344 rats are, these 2 strains were used to examine a possible association between disease severity and the level of nonspecific lymphocyte stimulation by mitogens, including M. pulmonis membrane preparations. F344 and LEW spleen, lung, blood, and lymph node lymphocytes were exposed to various mitogens. LEW lymphocytes gave a significantly higher response to mitogenic stimulation, regardless of their anatomical source. These differences in lymphocyte responsiveness were primarily due to differences within the nonadherent cell population. Significantly higher numbers of W3/25+ (T helper) cells were found in LEW lymphoid populations, whereas no difference was found in MRC OX-8+ (T suppressor/cytotoxic) cells. These data suggest an association between disease severity and host responsiveness to nonspecific stimuli.
AB - Mycoplasma pulmonis produces a mitogen which may play a role in the pathogenesis of murine respiratory mycoplasmosis in rats. Since LEW rats are more susceptible to this disease than F344 rats are, these 2 strains were used to examine a possible association between disease severity and the level of nonspecific lymphocyte stimulation by mitogens, including M. pulmonis membrane preparations. F344 and LEW spleen, lung, blood, and lymph node lymphocytes were exposed to various mitogens. LEW lymphocytes gave a significantly higher response to mitogenic stimulation, regardless of their anatomical source. These differences in lymphocyte responsiveness were primarily due to differences within the nonadherent cell population. Significantly higher numbers of W3/25+ (T helper) cells were found in LEW lymphoid populations, whereas no difference was found in MRC OX-8+ (T suppressor/cytotoxic) cells. These data suggest an association between disease severity and host responsiveness to nonspecific stimuli.
UR - http://www.scopus.com/inward/record.url?scp=0021878166&partnerID=8YFLogxK
U2 - 10.1128/iai.49.1.152-158.1985
DO - 10.1128/iai.49.1.152-158.1985
M3 - Article
C2 - 3159678
AN - SCOPUS:0021878166
SN - 0019-9567
VL - 49
SP - 152
EP - 158
JO - Infection and Immunity
JF - Infection and Immunity
IS - 1
ER -