Nonprimate models for glaucoma retinopathy and optic neuropathy

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

The generation and advancement of animal models have contributed significantly to the advancement of glaucoma research. This chapter describes and summarizes major nonprimate animal models useful for the study of this disease. Rodent models, both rats and mice, have been popular for glaucoma studies, because of the relatively better-developed genetic and genomic tools and the similarity of the relevant ocular structures between human and these animals. The larger animals, e.g., rabbit, feline, canine, bovine, ovine, and porcine models, have also been successfully used and provided valuable information on various aspects of the disease. Some of the models depicted in this chapter involve a transient or chronic ocular hypertension. Others do not affect intraocular pressure, but instead address certain specific mechanisms of the disease and serve as surrogate models.

Original languageEnglish
Title of host publicationAnimal Models for Retinal Diseases
EditorsLok-Hou Pang, Abbot Clark
Pages139-164
Number of pages26
DOIs
StatePublished - 25 Jan 2010

Publication series

NameNeuromethods
Volume46
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

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Keywords

  • Bovine
  • Canine
  • Feline
  • Glaucoma models
  • Glaucomatous optic neuropathy
  • Glaucomatous retinopathy
  • Ovine
  • Porcine
  • Rabbit
  • Rodent

Cite this

Pang, I-H., & Clark, A. (2010). Nonprimate models for glaucoma retinopathy and optic neuropathy. In L-H. Pang, & A. Clark (Eds.), Animal Models for Retinal Diseases (pp. 139-164). (Neuromethods; Vol. 46). https://doi.org/10.1007/978-1-60761-541-5_8