TY - JOUR
T1 - Nonhuman primate models of ischemic stroke and neurological evaluation after stroke
AU - Lin, Xiao
AU - Wang, Hua
AU - Chen, Jiayu
AU - Zhao, Peiqi
AU - Wen, Min
AU - Bingwa, Lebohang Anesu
AU - Jin, Kunlin
AU - Zhuge, Qichuan
AU - Yang, Su
N1 - Funding Information:
This research was funded by grants from the National Natural Science Foundation of China ( 81820108011 and 81771262 ), Zhejiang Provincial Natural Science Foundation ( 2020C03022 and 2017C03027 ).
Publisher Copyright:
© 2022 The Authors
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Nonhuman primates are closer to human beings than rodents in genetics, neuroanatomy, physiology and immunology. Nonhuman primates are therefore considered an ideal preclinical model to replicate various aspects of human stroke. Ischemia stroke models in nonhuman primates can better fit the physiological symptoms and changes in humans after cerebral ischemia. Currently, various construction methods and neurological evaluation methods have been developed and applied to stroke models of nonhuman primates, including craniectomy models, endovascular stroke models, autologous thrombus models and intraluminal filament models. Meanwhile, new innovative methods have emerged, such as the endothelin-1 model and photothrombosis model. In the past thirty years, these model studies have explored various mechanisms that are initiated in the first minutes, hours, and days after a stroke. Permanent and temporary middle cerebral artery occlusion models have been trying to simulate the complex situation of human stroke. However, a comprehensive comparison of the above methods, including their advantages and disadvantages, difficulty and application fields, is limited. Here, we introduce various modeling methods that are currently available for nonhuman primate stroke models, compare the differences between these different preparation methods, and analyze the advantages and disadvantages of the various methods and the fields of application. The imaging detection methods of nonhuman primates after cerebral ischemia and the neurological evaluation methods after stroke are also discussed briefly. Methods are sorted and compared so that scholars can choose appropriate modeling methods and evaluation methods to establish nonhuman primate stroke models.
AB - Nonhuman primates are closer to human beings than rodents in genetics, neuroanatomy, physiology and immunology. Nonhuman primates are therefore considered an ideal preclinical model to replicate various aspects of human stroke. Ischemia stroke models in nonhuman primates can better fit the physiological symptoms and changes in humans after cerebral ischemia. Currently, various construction methods and neurological evaluation methods have been developed and applied to stroke models of nonhuman primates, including craniectomy models, endovascular stroke models, autologous thrombus models and intraluminal filament models. Meanwhile, new innovative methods have emerged, such as the endothelin-1 model and photothrombosis model. In the past thirty years, these model studies have explored various mechanisms that are initiated in the first minutes, hours, and days after a stroke. Permanent and temporary middle cerebral artery occlusion models have been trying to simulate the complex situation of human stroke. However, a comprehensive comparison of the above methods, including their advantages and disadvantages, difficulty and application fields, is limited. Here, we introduce various modeling methods that are currently available for nonhuman primate stroke models, compare the differences between these different preparation methods, and analyze the advantages and disadvantages of the various methods and the fields of application. The imaging detection methods of nonhuman primates after cerebral ischemia and the neurological evaluation methods after stroke are also discussed briefly. Methods are sorted and compared so that scholars can choose appropriate modeling methods and evaluation methods to establish nonhuman primate stroke models.
KW - Ischemia stroke
KW - MCAO
KW - Neurological evaluation
KW - Nonhuman primates
UR - http://www.scopus.com/inward/record.url?scp=85129734318&partnerID=8YFLogxK
U2 - 10.1016/j.jneumeth.2022.109611
DO - 10.1016/j.jneumeth.2022.109611
M3 - Review article
C2 - 35487315
AN - SCOPUS:85129734318
SN - 0165-0270
VL - 376
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
M1 - 109611
ER -