Non-T, non-B lymphomas are rare in childhood and associated with cutaneous tumor

A. Bernard, S. B. Murphy, S. Melvin, W. P. Bowman, J. Caillaud, J. Lemerle, L. Boumsell

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Abstract

Tumor cells from a total of 116 children with non-Hodgkin's lymphoma were studied for their pattern of reactivity with a battery of cell markers, including their capacity for spontaneous formation of sheep erythrocyte rosettes (E-rosettes), demonstration of surface immunoglobulins (SIg), and positivity with antisera against T-cell antigens, the common acute-lymphoblastic-leukemia-associated antigen (cALLa), and Ia-like antigens. Fifty-eight children (50%) had T-cell lymphomas, including all those with mediastinal tumors. Fifty children (43%) had B-cell lymphomas, including 44 of the 45 with abdominal primaries. Eight children (7%) had non-T, non-B tumors, 4 of whom presented at a young age with cutaneous lymphoblastic tumors. These results demonstrate that the great majority of children with NHL, not leukemic at diagnosis, have tumors clearly committed to either T- or B-cell differentiation pathways and only rarely exhibit the common ALL phenotype (cALLa +,Ia+,E-,T-,SIg-), contrasting with the distribution of childhood lymphoblastic leukemias. The unusual association of these non-T, non-B cases with skin involvement has not previously been reported, raising speculation regarding patterns of lymphocyte traffic and origins of childhood lymphomas and leukemias.

Original languageEnglish
Pages (from-to)549-554
Number of pages6
JournalUnknown Journal
Volume59
Issue number3
DOIs
StatePublished - 1982

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    Bernard, A., Murphy, S. B., Melvin, S., Bowman, W. P., Caillaud, J., Lemerle, J., & Boumsell, L. (1982). Non-T, non-B lymphomas are rare in childhood and associated with cutaneous tumor. Unknown Journal, 59(3), 549-554. https://doi.org/10.1182/blood.v59.3.549.549