Non-T, non-B lymphomas are rare in childhood and associated with cutaneous tumor

A. Bernard, S. B. Murphy, S. Melvin, Paul Bowman, J. Caillaud, J. Lemerle, L. Boumsell

Research output: Contribution to journalArticle

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Abstract

Tumor cells from a total of 116 children with non-Hodgkin's lymphoma were studied for their pattern of reactivity with a battery of cell markers, including their capacity for spontaneous formation of sheep erythrocyte rosettes (E-rosettes), demonstration of surface immunoglobulins (SIg), and positivity with antisera against T-cell antigens, the common acute-lymphoblastic-leukemia-associated antigen (cALLa), and Ia-like antigens. Fifty-eight children (50%) had T-cell lymphomas, including all those with mediastinal tumors. Fifty children (43%) had B-cell lymphomas, including 44 of the 45 with abdominal primaries. Eight children (7%) had non-T, non-B tumors, 4 of whom presented at a young age with cutaneous lymphoblastic tumors. These results demonstrate that the great majority of children with NHL, not leukemic at diagnosis, have tumors clearly committed to either T- or B-cell differentiation pathways and only rarely exhibit the common ALL phenotype (cALLa +,Ia+,E-,T-,SIg-), contrasting with the distribution of childhood lymphoblastic leukemias. The unusual association of these non-T, non-B cases with skin involvement has not previously been reported, raising speculation regarding patterns of lymphocyte traffic and origins of childhood lymphomas and leukemias.

Original languageEnglish
Pages (from-to)549-554
Number of pages6
JournalBlood
Volume59
Issue number3
StatePublished - 5 May 1982

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Tumors
Lymphoma
Skin
Neprilysin
B-Cell Antigen Receptors
T-cells
Histocompatibility Antigens Class II
Cells
Neoplasms
Lymphocytes
T-Cell Lymphoma
Viral Tumor Antigens
B-Cell Lymphoma
Antigens
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Non-Hodgkin's Lymphoma
Immune Sera
Cell Differentiation
Sheep
Leukemia

Cite this

Bernard, A., Murphy, S. B., Melvin, S., Bowman, P., Caillaud, J., Lemerle, J., & Boumsell, L. (1982). Non-T, non-B lymphomas are rare in childhood and associated with cutaneous tumor. Blood, 59(3), 549-554.
Bernard, A. ; Murphy, S. B. ; Melvin, S. ; Bowman, Paul ; Caillaud, J. ; Lemerle, J. ; Boumsell, L. / Non-T, non-B lymphomas are rare in childhood and associated with cutaneous tumor. In: Blood. 1982 ; Vol. 59, No. 3. pp. 549-554.
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abstract = "Tumor cells from a total of 116 children with non-Hodgkin's lymphoma were studied for their pattern of reactivity with a battery of cell markers, including their capacity for spontaneous formation of sheep erythrocyte rosettes (E-rosettes), demonstration of surface immunoglobulins (SIg), and positivity with antisera against T-cell antigens, the common acute-lymphoblastic-leukemia-associated antigen (cALLa), and Ia-like antigens. Fifty-eight children (50{\%}) had T-cell lymphomas, including all those with mediastinal tumors. Fifty children (43{\%}) had B-cell lymphomas, including 44 of the 45 with abdominal primaries. Eight children (7{\%}) had non-T, non-B tumors, 4 of whom presented at a young age with cutaneous lymphoblastic tumors. These results demonstrate that the great majority of children with NHL, not leukemic at diagnosis, have tumors clearly committed to either T- or B-cell differentiation pathways and only rarely exhibit the common ALL phenotype (cALLa +,Ia+,E-,T-,SIg-), contrasting with the distribution of childhood lymphoblastic leukemias. The unusual association of these non-T, non-B cases with skin involvement has not previously been reported, raising speculation regarding patterns of lymphocyte traffic and origins of childhood lymphomas and leukemias.",
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Bernard, A, Murphy, SB, Melvin, S, Bowman, P, Caillaud, J, Lemerle, J & Boumsell, L 1982, 'Non-T, non-B lymphomas are rare in childhood and associated with cutaneous tumor', Blood, vol. 59, no. 3, pp. 549-554.

Non-T, non-B lymphomas are rare in childhood and associated with cutaneous tumor. / Bernard, A.; Murphy, S. B.; Melvin, S.; Bowman, Paul; Caillaud, J.; Lemerle, J.; Boumsell, L.

In: Blood, Vol. 59, No. 3, 05.05.1982, p. 549-554.

Research output: Contribution to journalArticle

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AU - Bernard, A.

AU - Murphy, S. B.

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AU - Lemerle, J.

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N2 - Tumor cells from a total of 116 children with non-Hodgkin's lymphoma were studied for their pattern of reactivity with a battery of cell markers, including their capacity for spontaneous formation of sheep erythrocyte rosettes (E-rosettes), demonstration of surface immunoglobulins (SIg), and positivity with antisera against T-cell antigens, the common acute-lymphoblastic-leukemia-associated antigen (cALLa), and Ia-like antigens. Fifty-eight children (50%) had T-cell lymphomas, including all those with mediastinal tumors. Fifty children (43%) had B-cell lymphomas, including 44 of the 45 with abdominal primaries. Eight children (7%) had non-T, non-B tumors, 4 of whom presented at a young age with cutaneous lymphoblastic tumors. These results demonstrate that the great majority of children with NHL, not leukemic at diagnosis, have tumors clearly committed to either T- or B-cell differentiation pathways and only rarely exhibit the common ALL phenotype (cALLa +,Ia+,E-,T-,SIg-), contrasting with the distribution of childhood lymphoblastic leukemias. The unusual association of these non-T, non-B cases with skin involvement has not previously been reported, raising speculation regarding patterns of lymphocyte traffic and origins of childhood lymphomas and leukemias.

AB - Tumor cells from a total of 116 children with non-Hodgkin's lymphoma were studied for their pattern of reactivity with a battery of cell markers, including their capacity for spontaneous formation of sheep erythrocyte rosettes (E-rosettes), demonstration of surface immunoglobulins (SIg), and positivity with antisera against T-cell antigens, the common acute-lymphoblastic-leukemia-associated antigen (cALLa), and Ia-like antigens. Fifty-eight children (50%) had T-cell lymphomas, including all those with mediastinal tumors. Fifty children (43%) had B-cell lymphomas, including 44 of the 45 with abdominal primaries. Eight children (7%) had non-T, non-B tumors, 4 of whom presented at a young age with cutaneous lymphoblastic tumors. These results demonstrate that the great majority of children with NHL, not leukemic at diagnosis, have tumors clearly committed to either T- or B-cell differentiation pathways and only rarely exhibit the common ALL phenotype (cALLa +,Ia+,E-,T-,SIg-), contrasting with the distribution of childhood lymphoblastic leukemias. The unusual association of these non-T, non-B cases with skin involvement has not previously been reported, raising speculation regarding patterns of lymphocyte traffic and origins of childhood lymphomas and leukemias.

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Bernard A, Murphy SB, Melvin S, Bowman P, Caillaud J, Lemerle J et al. Non-T, non-B lymphomas are rare in childhood and associated with cutaneous tumor. Blood. 1982 May 5;59(3):549-554.