Non-steroidal anti-inflammatory drug (NSAID) use and breast cancer risk in the Western New York exposures and breast cancer (WEB) study

Theodore M. Brasky, Matthew R. Bonner, Kirsten B. Moysich, Christine B. Ambrosone, Jing Nie, Menghua Tao, Stephen B. Edge, Bhaskar V.S. Kallakury, Catalin Marian, Maurizio Trevisan, Peter G. Shields, Jo L. Freudenheim

Research output: Contribution to journalArticle

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Abstract

Objective: Chronic inflammation is suspected to have a role in breast carcinogenesis. Results of studies of non-steroidal anti-inflammatory drugs (NSAIDs) and breast cancer have been inconsistent. Timing of exposure and analysis of individual NSAIDs should be considered. Methods: We conducted a population-based case-control study in western New York State between 1996 and 2001. Cases, 35-79 years, had incident, primary, histologically confirmed breast cancer (n = 1,170). Controls (n = 2,115) were randomly selected from NY Department of Motor Vehicles records (<65 years) or Medicare rolls (≥65 years). Participants were queried on use of aspirin, ibuprofen, and acetaminophen in the year prior and on aspirin during adulthood. Unconditional logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (95% CI). Results: Recent aspirin use was inversely associated with breast cancer risk (adjusted OR 0.80, 95% CI: 0.68-0.94); the strongest reduction in risk was observed among those who took ≥2 pills/day on days that aspirin was taken (OR 0.74, 95% CI: 0.61-0. 90). Adult lifetime use was also associated with breast cancer risk (>10 days/month, adjusted OR 0.68, 95% CI: 0.46-1.00). Use of ibuprofen or acetaminophen was not associated with breast cancer. Conclusions: This is the first study to investigate the association of adult lifetime aspirin intake with breast cancer risk. Our findings provide evidence that aspirin use throughout a woman's life may confer some benefit.

Original languageEnglish
Pages (from-to)1503-1512
Number of pages10
JournalCancer Causes and Control
Volume21
Issue number9
DOIs
StatePublished - 1 Sep 2010

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Anti-Inflammatory Agents
Breast Neoplasms
Aspirin
Inflammatory Breast Neoplasms
Pharmaceutical Preparations
Ibuprofen
Motor Vehicles
Acetaminophen
Case-Control Studies
Carcinogenesis
Breast
Inflammation
Population

Keywords

  • Aspirin
  • Breast cancer
  • Ibuprofen
  • Inflammation
  • Non-steroidal anti-inflammatory drugs

Cite this

Brasky, Theodore M. ; Bonner, Matthew R. ; Moysich, Kirsten B. ; Ambrosone, Christine B. ; Nie, Jing ; Tao, Menghua ; Edge, Stephen B. ; Kallakury, Bhaskar V.S. ; Marian, Catalin ; Trevisan, Maurizio ; Shields, Peter G. ; Freudenheim, Jo L. / Non-steroidal anti-inflammatory drug (NSAID) use and breast cancer risk in the Western New York exposures and breast cancer (WEB) study. In: Cancer Causes and Control. 2010 ; Vol. 21, No. 9. pp. 1503-1512.
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title = "Non-steroidal anti-inflammatory drug (NSAID) use and breast cancer risk in the Western New York exposures and breast cancer (WEB) study",
abstract = "Objective: Chronic inflammation is suspected to have a role in breast carcinogenesis. Results of studies of non-steroidal anti-inflammatory drugs (NSAIDs) and breast cancer have been inconsistent. Timing of exposure and analysis of individual NSAIDs should be considered. Methods: We conducted a population-based case-control study in western New York State between 1996 and 2001. Cases, 35-79 years, had incident, primary, histologically confirmed breast cancer (n = 1,170). Controls (n = 2,115) were randomly selected from NY Department of Motor Vehicles records (<65 years) or Medicare rolls (≥65 years). Participants were queried on use of aspirin, ibuprofen, and acetaminophen in the year prior and on aspirin during adulthood. Unconditional logistic regression was used to estimate adjusted odds ratios (OR) and 95{\%} confidence intervals (95{\%} CI). Results: Recent aspirin use was inversely associated with breast cancer risk (adjusted OR 0.80, 95{\%} CI: 0.68-0.94); the strongest reduction in risk was observed among those who took ≥2 pills/day on days that aspirin was taken (OR 0.74, 95{\%} CI: 0.61-0. 90). Adult lifetime use was also associated with breast cancer risk (>10 days/month, adjusted OR 0.68, 95{\%} CI: 0.46-1.00). Use of ibuprofen or acetaminophen was not associated with breast cancer. Conclusions: This is the first study to investigate the association of adult lifetime aspirin intake with breast cancer risk. Our findings provide evidence that aspirin use throughout a woman's life may confer some benefit.",
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author = "Brasky, {Theodore M.} and Bonner, {Matthew R.} and Moysich, {Kirsten B.} and Ambrosone, {Christine B.} and Jing Nie and Menghua Tao and Edge, {Stephen B.} and Kallakury, {Bhaskar V.S.} and Catalin Marian and Maurizio Trevisan and Shields, {Peter G.} and Freudenheim, {Jo L.}",
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Brasky, TM, Bonner, MR, Moysich, KB, Ambrosone, CB, Nie, J, Tao, M, Edge, SB, Kallakury, BVS, Marian, C, Trevisan, M, Shields, PG & Freudenheim, JL 2010, 'Non-steroidal anti-inflammatory drug (NSAID) use and breast cancer risk in the Western New York exposures and breast cancer (WEB) study', Cancer Causes and Control, vol. 21, no. 9, pp. 1503-1512. https://doi.org/10.1007/s10552-010-9579-5

Non-steroidal anti-inflammatory drug (NSAID) use and breast cancer risk in the Western New York exposures and breast cancer (WEB) study. / Brasky, Theodore M.; Bonner, Matthew R.; Moysich, Kirsten B.; Ambrosone, Christine B.; Nie, Jing; Tao, Menghua; Edge, Stephen B.; Kallakury, Bhaskar V.S.; Marian, Catalin; Trevisan, Maurizio; Shields, Peter G.; Freudenheim, Jo L.

In: Cancer Causes and Control, Vol. 21, No. 9, 01.09.2010, p. 1503-1512.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Non-steroidal anti-inflammatory drug (NSAID) use and breast cancer risk in the Western New York exposures and breast cancer (WEB) study

AU - Brasky, Theodore M.

AU - Bonner, Matthew R.

AU - Moysich, Kirsten B.

AU - Ambrosone, Christine B.

AU - Nie, Jing

AU - Tao, Menghua

AU - Edge, Stephen B.

AU - Kallakury, Bhaskar V.S.

AU - Marian, Catalin

AU - Trevisan, Maurizio

AU - Shields, Peter G.

AU - Freudenheim, Jo L.

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Objective: Chronic inflammation is suspected to have a role in breast carcinogenesis. Results of studies of non-steroidal anti-inflammatory drugs (NSAIDs) and breast cancer have been inconsistent. Timing of exposure and analysis of individual NSAIDs should be considered. Methods: We conducted a population-based case-control study in western New York State between 1996 and 2001. Cases, 35-79 years, had incident, primary, histologically confirmed breast cancer (n = 1,170). Controls (n = 2,115) were randomly selected from NY Department of Motor Vehicles records (<65 years) or Medicare rolls (≥65 years). Participants were queried on use of aspirin, ibuprofen, and acetaminophen in the year prior and on aspirin during adulthood. Unconditional logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (95% CI). Results: Recent aspirin use was inversely associated with breast cancer risk (adjusted OR 0.80, 95% CI: 0.68-0.94); the strongest reduction in risk was observed among those who took ≥2 pills/day on days that aspirin was taken (OR 0.74, 95% CI: 0.61-0. 90). Adult lifetime use was also associated with breast cancer risk (>10 days/month, adjusted OR 0.68, 95% CI: 0.46-1.00). Use of ibuprofen or acetaminophen was not associated with breast cancer. Conclusions: This is the first study to investigate the association of adult lifetime aspirin intake with breast cancer risk. Our findings provide evidence that aspirin use throughout a woman's life may confer some benefit.

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