@article{afcf07c522694f7e9ec88a26993c547f,
title = "Non-homologous use of adipose-derived cell and tissue therapies: Osteoarthritis as a case study",
abstract = "Adipose tissue is widely recognized as an abundant and accessible human tissue that serves as a source of cells and extracellular matrix scaffolds for regenerative surgical applications. Increasingly, orthopedic surgeons are turning to adipose tissue as a resource in their treatment of osteoarthritis and related conditions. In the U.S., the regulatory landscape governing the orthopedic surgical utilization of autologous and allogeneic adipose tissue remains complex. This manuscript reviews the Food and Drug Administration's nomenclature and guidance regarding adipose tissue products. Additionally, it surveys recent pre-clinical and clinical trial literature relating to the application of adipose-derived cells and tissues in the treatment of osteoarthritis.",
keywords = "Adipose, Microfragmented fat, Osteoarthritis, Regenerative medicine, Regulatory agency, Stromal/stem cells",
author = "Trivia Frazier and Keith March and Garza, {Jaime R.} and Bunnell, {Bruce A.} and Darr, {Kevin F.} and Emma Rogers and Katie Hamel and Gimble, {Jeffrey M.}",
note = "Funding Information: T. Frazier and J.M. Gimble are co-founders, co-owners, and employees of Obatala Sciences, a for-profit biotechnology company focused on the development of adipose-derived cell and biomaterial products for research and clinical translational applications. They are co-inventors on patents relating to such products. Likewise, K. Hamel and E. Rogers are employees of Obatala Sciences. K. Darr is a co-owner and employee of Covington Orthopedics Sports Medicine Institute. K. March is actively involved as a developer and founder of TrueTrials.org , a 501c3 non-profit entity. J.R. Garza has received funding from the GID Group and InGeneron for the conduct of clinical trials and funding as a Medical Monitor/DSMB member for an FDA trial with 3D Bio. B.A. Bunnell, J.M. Gimble and K. March are former presidents and active board members of the International Federation of Adipose Therapeutics and Sciences (IFATS), a non-profit organization promoting research and clinical translation of adipose tissue products. Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = dec,
doi = "10.1016/j.bonr.2022.101601",
language = "English",
volume = "17",
journal = "Bone Reports",
issn = "2352-1872",
publisher = "Elsevier Inc.",
}