No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women

Results from a multicenter study in Eastern and Central Europe

Ann Davis, Menghua Tao, Jia Chen, Ghislaine Scelo, Vladimir Bencko, Eleonora Fabianova, Lenka Foretova, Vladimir Janout, Jolanta Lissowska, Dana Mates, Ioan N. Mates, Peter Rudnai, David Zaridze, Paolo Boffetta

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2 Citations (Scopus)

Abstract

Alterations in global DNA methylation have been suggested to play an important role in cancer development. We evaluated the association of global DNA methylation in peripheral blood with the risk of lung cancer in nonsmoking women from six countries in Central and Eastern Europe. This multicenter case-control study included primary, incident lung cancer cases diagnosed from 1998 to 2001 and controls frequency-matched for geographic area, sex, and age. Global methylation was assessed in peripheral blood DNA from 83 nonsmoking female cases and 181 nonsmoking female controls using the luminometric methylation assay (LUMA). Unconditional logistic regression models were used to estimate associations between DNA methylation in the blood and the risk of lung cancer. LUMA methylation level was not associated with the risk of lung cancer in nonsmoking women. Associations were not significantly different according to different strata of age, BMI, alcohol drinking, or second-hand tobacco smoke exposure status. In our study of nonsmoking women, the LUMA methylation level in peripheral blood was not associated with the risk of lung cancer. Our findings do not support an association of global blood DNA methylation with the risk of lung cancer in nonsmoking women.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalEuropean Journal of Cancer Prevention
Volume27
Issue number1
DOIs
StatePublished - 1 Jan 2018

Fingerprint

Eastern Europe
DNA Methylation
Methylation
Multicenter Studies
Lung Neoplasms
Logistic Models
Tobacco Smoke Pollution
Alcohol Drinking
Tobacco
Case-Control Studies
DNA
Neoplasms

Keywords

  • epidemiology
  • global methylation
  • lung cancer
  • never-smoking women

Cite this

Davis, Ann ; Tao, Menghua ; Chen, Jia ; Scelo, Ghislaine ; Bencko, Vladimir ; Fabianova, Eleonora ; Foretova, Lenka ; Janout, Vladimir ; Lissowska, Jolanta ; Mates, Dana ; Mates, Ioan N. ; Rudnai, Peter ; Zaridze, David ; Boffetta, Paolo. / No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women : Results from a multicenter study in Eastern and Central Europe. In: European Journal of Cancer Prevention. 2018 ; Vol. 27, No. 1. pp. 1-5.
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abstract = "Alterations in global DNA methylation have been suggested to play an important role in cancer development. We evaluated the association of global DNA methylation in peripheral blood with the risk of lung cancer in nonsmoking women from six countries in Central and Eastern Europe. This multicenter case-control study included primary, incident lung cancer cases diagnosed from 1998 to 2001 and controls frequency-matched for geographic area, sex, and age. Global methylation was assessed in peripheral blood DNA from 83 nonsmoking female cases and 181 nonsmoking female controls using the luminometric methylation assay (LUMA). Unconditional logistic regression models were used to estimate associations between DNA methylation in the blood and the risk of lung cancer. LUMA methylation level was not associated with the risk of lung cancer in nonsmoking women. Associations were not significantly different according to different strata of age, BMI, alcohol drinking, or second-hand tobacco smoke exposure status. In our study of nonsmoking women, the LUMA methylation level in peripheral blood was not associated with the risk of lung cancer. Our findings do not support an association of global blood DNA methylation with the risk of lung cancer in nonsmoking women.",
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author = "Ann Davis and Menghua Tao and Jia Chen and Ghislaine Scelo and Vladimir Bencko and Eleonora Fabianova and Lenka Foretova and Vladimir Janout and Jolanta Lissowska and Dana Mates and Mates, {Ioan N.} and Peter Rudnai and David Zaridze and Paolo Boffetta",
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Davis, A, Tao, M, Chen, J, Scelo, G, Bencko, V, Fabianova, E, Foretova, L, Janout, V, Lissowska, J, Mates, D, Mates, IN, Rudnai, P, Zaridze, D & Boffetta, P 2018, 'No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: Results from a multicenter study in Eastern and Central Europe', European Journal of Cancer Prevention, vol. 27, no. 1, pp. 1-5. https://doi.org/10.1097/CEJ.0000000000000244

No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women : Results from a multicenter study in Eastern and Central Europe. / Davis, Ann; Tao, Menghua; Chen, Jia; Scelo, Ghislaine; Bencko, Vladimir; Fabianova, Eleonora; Foretova, Lenka; Janout, Vladimir; Lissowska, Jolanta; Mates, Dana; Mates, Ioan N.; Rudnai, Peter; Zaridze, David; Boffetta, Paolo.

In: European Journal of Cancer Prevention, Vol. 27, No. 1, 01.01.2018, p. 1-5.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women

T2 - Results from a multicenter study in Eastern and Central Europe

AU - Davis, Ann

AU - Tao, Menghua

AU - Chen, Jia

AU - Scelo, Ghislaine

AU - Bencko, Vladimir

AU - Fabianova, Eleonora

AU - Foretova, Lenka

AU - Janout, Vladimir

AU - Lissowska, Jolanta

AU - Mates, Dana

AU - Mates, Ioan N.

AU - Rudnai, Peter

AU - Zaridze, David

AU - Boffetta, Paolo

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N2 - Alterations in global DNA methylation have been suggested to play an important role in cancer development. We evaluated the association of global DNA methylation in peripheral blood with the risk of lung cancer in nonsmoking women from six countries in Central and Eastern Europe. This multicenter case-control study included primary, incident lung cancer cases diagnosed from 1998 to 2001 and controls frequency-matched for geographic area, sex, and age. Global methylation was assessed in peripheral blood DNA from 83 nonsmoking female cases and 181 nonsmoking female controls using the luminometric methylation assay (LUMA). Unconditional logistic regression models were used to estimate associations between DNA methylation in the blood and the risk of lung cancer. LUMA methylation level was not associated with the risk of lung cancer in nonsmoking women. Associations were not significantly different according to different strata of age, BMI, alcohol drinking, or second-hand tobacco smoke exposure status. In our study of nonsmoking women, the LUMA methylation level in peripheral blood was not associated with the risk of lung cancer. Our findings do not support an association of global blood DNA methylation with the risk of lung cancer in nonsmoking women.

AB - Alterations in global DNA methylation have been suggested to play an important role in cancer development. We evaluated the association of global DNA methylation in peripheral blood with the risk of lung cancer in nonsmoking women from six countries in Central and Eastern Europe. This multicenter case-control study included primary, incident lung cancer cases diagnosed from 1998 to 2001 and controls frequency-matched for geographic area, sex, and age. Global methylation was assessed in peripheral blood DNA from 83 nonsmoking female cases and 181 nonsmoking female controls using the luminometric methylation assay (LUMA). Unconditional logistic regression models were used to estimate associations between DNA methylation in the blood and the risk of lung cancer. LUMA methylation level was not associated with the risk of lung cancer in nonsmoking women. Associations were not significantly different according to different strata of age, BMI, alcohol drinking, or second-hand tobacco smoke exposure status. In our study of nonsmoking women, the LUMA methylation level in peripheral blood was not associated with the risk of lung cancer. Our findings do not support an association of global blood DNA methylation with the risk of lung cancer in nonsmoking women.

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KW - global methylation

KW - lung cancer

KW - never-smoking women

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