New structures of the O-specific polysaccharides of Proteus. 4. Polysaccharides containing unusual acidic N-acyl derivatives of 4-amino-4,6-dideoxy-D-glucose

A. N. Kondakova; B. Linder; R. Fudala; S. N. Senchenkova; H. Moll; A. S. Shashkov; W. Kaca; U. Zähringer; Y. A. Knirel

doi:10.1023/B:BIRY.0000043546.46903.32

New structures of the O-specific polysaccharides of Proteus. 4. Polysaccharides containing unusual acidic N-acyl derivatives of 4-amino-4,6-dideoxy-D-glucose

A. N. Kondakova, B. Linder, R. Fudala, S. N. Senchenkova, H. Moll, A. S. Shashkov, W. Kaca, U. Zähringer, Y. A. Knirel

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Abstract

The structures of the O-polysaccharides of the lipopolysaccharides of Proteus mirabilis O7 and O49 were determined by chemical methods, mass spectrometry, including MS/MS, and NMR spectroscopy, including experiments run in an H₂O/D₂O mixture to reveal correlations for NH protons. The O-polysaccharides were found to contain N-carboxyacetyl (malonyl) and N-(3-carboxypropanoyl) (succinyl) derivatives of 4-amino-4,6-dideoxyglucose (4-amino-4-deoxyquinovose, Qui4N), respectively. The behavior of Qui4N derivatives with the dicarboxylic acids under conditions of acid hydrolysis and methanolysis was studied using GLC-MS.

Original language	English
Pages (from-to)	1034-1043
Number of pages	10
Journal	Biochemistry (Moscow)
Volume	69
Issue number	9
DOIs	https://doi.org/10.1023/B:BIRY.0000043546.46903.32
State	Published - Sep 2004

Keywords

4-amino-4,6-dideoxy-d-glucose
Aspartic acid
MS/MS
Malonic acid
O-polysaccharide
Proteus mirabilis
Succinic acid

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Kondakova, A. N., Linder, B., Fudala, R., Senchenkova, S. N., Moll, H., Shashkov, A. S., Kaca, W., Zähringer, U., & Knirel, Y. A. (2004). New structures of the O-specific polysaccharides of Proteus. 4. Polysaccharides containing unusual acidic N-acyl derivatives of 4-amino-4,6-dideoxy-D-glucose. Biochemistry (Moscow), 69(9), 1034-1043. https://doi.org/10.1023/B:BIRY.0000043546.46903.32

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title = "New structures of the O-specific polysaccharides of Proteus. 4. Polysaccharides containing unusual acidic N-acyl derivatives of 4-amino-4,6-dideoxy-D-glucose",

abstract = "The structures of the O-polysaccharides of the lipopolysaccharides of Proteus mirabilis O7 and O49 were determined by chemical methods, mass spectrometry, including MS/MS, and NMR spectroscopy, including experiments run in an H2O/D2O mixture to reveal correlations for NH protons. The O-polysaccharides were found to contain N-carboxyacetyl (malonyl) and N-(3-carboxypropanoyl) (succinyl) derivatives of 4-amino-4,6-dideoxyglucose (4-amino-4-deoxyquinovose, Qui4N), respectively. The behavior of Qui4N derivatives with the dicarboxylic acids under conditions of acid hydrolysis and methanolysis was studied using GLC-MS.",

keywords = "4-amino-4,6-dideoxy-d-glucose, Aspartic acid, MS/MS, Malonic acid, O-polysaccharide, Proteus mirabilis, Succinic acid",

author = "Kondakova, {A. N.} and B. Linder and R. Fudala and Senchenkova, {S. N.} and H. Moll and Shashkov, {A. S.} and W. Kaca and U. Z{\"a}hringer and Knirel, {Y. A.}",

year = "2004",

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doi = "10.1023/B:BIRY.0000043546.46903.32",

language = "English",

volume = "69",

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journal = "Biochemistry (Moscow)",

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number = "9",

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Kondakova, AN, Linder, B, Fudala, R, Senchenkova, SN, Moll, H, Shashkov, AS, Kaca, W, Zähringer, U & Knirel, YA 2004, 'New structures of the O-specific polysaccharides of Proteus. 4. Polysaccharides containing unusual acidic N-acyl derivatives of 4-amino-4,6-dideoxy-D-glucose', Biochemistry (Moscow), vol. 69, no. 9, pp. 1034-1043. https://doi.org/10.1023/B:BIRY.0000043546.46903.32

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T1 - New structures of the O-specific polysaccharides of Proteus. 4. Polysaccharides containing unusual acidic N-acyl derivatives of 4-amino-4,6-dideoxy-D-glucose

AU - Kondakova, A. N.

AU - Linder, B.

AU - Fudala, R.

AU - Senchenkova, S. N.

AU - Moll, H.

AU - Shashkov, A. S.

AU - Kaca, W.

AU - Zähringer, U.

AU - Knirel, Y. A.

PY - 2004/9

Y1 - 2004/9

N2 - The structures of the O-polysaccharides of the lipopolysaccharides of Proteus mirabilis O7 and O49 were determined by chemical methods, mass spectrometry, including MS/MS, and NMR spectroscopy, including experiments run in an H2O/D2O mixture to reveal correlations for NH protons. The O-polysaccharides were found to contain N-carboxyacetyl (malonyl) and N-(3-carboxypropanoyl) (succinyl) derivatives of 4-amino-4,6-dideoxyglucose (4-amino-4-deoxyquinovose, Qui4N), respectively. The behavior of Qui4N derivatives with the dicarboxylic acids under conditions of acid hydrolysis and methanolysis was studied using GLC-MS.

AB - The structures of the O-polysaccharides of the lipopolysaccharides of Proteus mirabilis O7 and O49 were determined by chemical methods, mass spectrometry, including MS/MS, and NMR spectroscopy, including experiments run in an H2O/D2O mixture to reveal correlations for NH protons. The O-polysaccharides were found to contain N-carboxyacetyl (malonyl) and N-(3-carboxypropanoyl) (succinyl) derivatives of 4-amino-4,6-dideoxyglucose (4-amino-4-deoxyquinovose, Qui4N), respectively. The behavior of Qui4N derivatives with the dicarboxylic acids under conditions of acid hydrolysis and methanolysis was studied using GLC-MS.

KW - 4-amino-4,6-dideoxy-d-glucose

KW - Aspartic acid

KW - MS/MS

KW - Malonic acid

KW - O-polysaccharide

KW - Proteus mirabilis

KW - Succinic acid

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AN - SCOPUS:10044275297

SN - 0006-2979

VL - 69

SP - 1034

EP - 1043

JO - Biochemistry (Moscow)

JF - Biochemistry (Moscow)

IS - 9

ER -

New structures of the O-specific polysaccharides of Proteus. 4. Polysaccharides containing unusual acidic N-acyl derivatives of 4-amino-4,6-dideoxy-D-glucose

Abstract

Keywords

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