New insights into the genetic organization of the FK228 biosynthetic gene cluster in chromobacterium violaceum No. 968

Vishwakanth Y. Potharla, Shane R. Wesener, Yi Qiang Cheng

Research output: Contribution to journalArticle

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Abstract

The biosynthetic gene cluster of FK228, an FDA-approved anticancer natural product, was identified and sequenced previously. The genetic organization of this gene cluster has now been delineated through systematic gene deletion and transcriptional analysis. As a result, the gene cluster is redefined to contain 12 genes: depA through depJ, depM, and a newly identified pathway regulatory gene, depR.

Original languageEnglish
Pages (from-to)1508-1511
Number of pages4
JournalApplied and Environmental Microbiology
Volume77
Issue number4
DOIs
Publication statusPublished - Feb 2011

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