New insights into the genetic organization of the FK228 biosynthetic gene cluster in chromobacterium violaceum No. 968

Vishwakanth Y. Potharla, Shane R. Wesener, Yi Qiang Cheng

Research output: Contribution to journalArticle

14 Scopus citations


The biosynthetic gene cluster of FK228, an FDA-approved anticancer natural product, was identified and sequenced previously. The genetic organization of this gene cluster has now been delineated through systematic gene deletion and transcriptional analysis. As a result, the gene cluster is redefined to contain 12 genes: depA through depJ, depM, and a newly identified pathway regulatory gene, depR.

Original languageEnglish
Pages (from-to)1508-1511
Number of pages4
JournalApplied and Environmental Microbiology
Issue number4
Publication statusPublished - Feb 2011


Cite this