TY - JOUR
T1 - New concepts on the immune modulation mediated by mesenchymal stem cells
AU - Bunnell, Bruce A.
AU - Betancourt, Aline M.
AU - Sullivan, Deborah E.
N1 - Funding Information:
The authors wish to acknowledge Ms Linda Ledet for excellent administrative and editorial assistance. The project described was supported by Award Number F31NS062588 from the National Institutes of Neurological Disorders and Stroke (NINDS), NIH/NINDS R21-NS059665, Louisiana Gene Therapy Research Consortium, and Tulane University to BAB. Funding was also provided to AMB by the National Institutes of Health 1P20RR20152-01 and Department of Defense OC073102 Concept Award and research support was obtained also from the Tulane Cancer Center and Center for Stem cell Research and Regenerative Medicine.
PY - 2010
Y1 - 2010
N2 - Mesenchymal stem cells (MSCs) are the nonhematopoietic multipotent progenitor cells found in various adult tissues. They are characterized by their ease of isolation and their rapid growth in vitro while maintaining their differentiation potential, allowing for extensive expansion in culture that yields large quantities suitable for therapeutic use. This article reviews the immunomodulatory activities associated with MSCs. Numerous studies have demonstrated that MSCs are potently immunosuppressive in vitro and in vivo. However, this article presents a new paradigm in MSC biology, in which MSCs, at least in vitro, can undergo polarization into either a pro-inflammatory or an immunosuppressive phenotype.
AB - Mesenchymal stem cells (MSCs) are the nonhematopoietic multipotent progenitor cells found in various adult tissues. They are characterized by their ease of isolation and their rapid growth in vitro while maintaining their differentiation potential, allowing for extensive expansion in culture that yields large quantities suitable for therapeutic use. This article reviews the immunomodulatory activities associated with MSCs. Numerous studies have demonstrated that MSCs are potently immunosuppressive in vitro and in vivo. However, this article presents a new paradigm in MSC biology, in which MSCs, at least in vitro, can undergo polarization into either a pro-inflammatory or an immunosuppressive phenotype.
UR - http://www.scopus.com/inward/record.url?scp=80052422003&partnerID=8YFLogxK
U2 - 10.1186/scrt34
DO - 10.1186/scrt34
M3 - Review article
C2 - 21092149
AN - SCOPUS:80052422003
SN - 1757-6512
VL - 1
JO - Stem Cell Research and Therapy
JF - Stem Cell Research and Therapy
IS - 5
M1 - 34
ER -