Neuroprotective effect of Sigma-2 modulator CT2074 in a mouse model of ocular hypertension

Keyphrases

• Ocular Hypertension 100%
• Neuroprotective Effect 100%
• Mouse Model 100%
• Retina 100%
• Retinal Ganglion Cells 100%
• Sigma-2 100%
• Neurodegenerative Diseases 75%
• Optic Nerve 75%
• Axon 75%
• Nave 75%
• Sigma-2 Receptor 75%
• Glaucoma 50%
• Anterograde Transport 50%
• Intraocular Pressure 25%
• Elevated Intraocular Pressure 25%
• Primary Open-angle Glaucoma 25%
• Neuroprotection 25%
• Brain Tissue 25%
• Treatment Group 25%
• Cell Density 25%
• Causes of Blindness 25%
• Drug Exposure 25%
• Nerve Tissue 25%
• Oral Administration 25%
• Retinal Ganglion Cell Axons 25%
• Axonal Loss 25%
• Male Mice 25%
• Receptor Occupancy 25%
• Current Therapies 25%
• Targeted Therapeutics 25%
• Neuroprotective Potential 25%
• Intraocular Injection 25%
• Receptor Targets 25%
• Vehicle Groups 25%
• Unmet Needs 25%
• Cholera Toxin B 25%
• Magnetic Beads 25%
• Optic Neuroprotection 25%
• Druggable Targets 25%
• Receptor Modulators 25%
• Cell Quantification 25%

Neuroscience

• Ocular Hypertension 100%
• Retinal Ganglion Cell 100%
• Neuroprotective Agent 100%
• Axon 80%
• Optic Nerve 60%
• Neurodegenerative Disorder 60%
• Sigma 2 Opiate Receptor 60%
• Intraocular Pressure 40%
• Glaucoma 40%
• Neuroprotection 40%
• Open-Angle Glaucoma 20%
• Cell Density 20%
• Receptor Occupancy 20%
• Cholera Toxin 20%
• Receptor Modulator 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Intraocular Hypertension 100%
• Neuroprotective Agent 100%
• Mouse Model 100%
• Sigma 2 Opiate Receptor 100%
• Glaucoma 66%
• Neuroprotection 66%
• Degenerative Disease 66%
• Open Angle Glaucoma 33%
• Receptor 33%
• Cholera Toxin 33%
• Treatment Group 33%
• Oral Administration 33%