@article{ed93b64f5d0646898c7006e52edfc39f,
title = "Neuronal injury regulates fractalkine: Relevance for HIV-1 associated dementia",
abstract = "Fractalkine (FKN), a chemokine highly expressed in the central nervous system, participates in inflammatory responses operative in many brain disorders including HIV-1 associated dementia (HAD). In this report, HIV-1 progeny virions and pro-inflammatory products led to FKN production associated with neuronal injury and apoptosis. FKN was produced by neurons and astrocytes; but differentially produced by the two cell types. Laboratory tests paralleled those in infected people where cerebrospinal fluid FKN levels in HIV-1 infected cognitively impaired (n=16) patients were found to be increased when compared to infected patients without cognitive impairment (n=8, P=0.0345). These results demonstrate a possible role of FKN in HAD pathogenesis.",
keywords = "Chemokines, Fractalkine, HIV-1 associated dementia, Inflammation, Macrophage",
author = "David Erichsen and Lopez, {Alicia L.} and Hui Peng and Douglas Niemann and Clancy Williams and Michael Bauer and Susan Morgello and Cotter, {Robin L.} and Ryan, {Lisa A.} and Anuja Ghorpade and Gendelman, {Howard E.} and Jialin Zheng",
note = "Funding Information: This work was supported in part by National Institutes of Health research grants: R01 NS 41858-01 (to JZ) and P20 RR15635-01 (to JZ and HEG). Funding Information: We kindly thank Manhattan HIV Brain Bank for providing the cerebrospinal fluid samples from HIV-1 infected subjects which is currently supported by NIH (R24MH59724); Ms. Robin Shepard for critically reading this manuscript; Ms. Li Wu and Ms. Lesley Gendelman for technical support; and Ms. Julie Ditter, Ms. Robin Taylor, Ms. Theresa Grutel and Ms. Nellie Ingraham for outstanding administrative support. ",
year = "2003",
month = may,
doi = "10.1016/S0165-5728(03)00117-6",
language = "English",
volume = "138",
pages = "144--155",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",
}