Neuronal injury from cardiac arrest: aging years in minutes

Brandon H. Cherry, Nathalie Sumien, Robert T. Mallet

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Cardiac arrest is a leading cause of death and permanent disability. Most victims succumb to the oxidative and inflammatory damage sustained during cardiac arrest/resuscitation, but even survivors typically battle long-term neurocognitive impairment. Although extensive research has delineated the complex mechanisms that culminate in neuronal damage and death, no effective treatments have been developed to interrupt these mechanisms. Of importance, many of these injury cascades are also active in the aging brain, where neurons and other cells are under persistent oxidative and inflammatory stress which eventually damages or kills the cells. In light of these similarities, it is reasonable to propose that the brain essentially ages the equivalent of several years within the few minutes taken to resuscitate a patient from cardiac arrest. Accordingly, cardiac arrest-resuscitation models may afford an opportunity to study the deleterious mechanisms underlying the aging process, on an accelerated time course. The aging and resuscitation fields both stand to gain pivotal insights from one another regarding the mechanisms of injury sustained during resuscitation from cardiac arrest and during aging. This synergism between the two fields could be harnessed to foster development of treatments to not only save lives but also to enhance the quality of life for the elderly.

Original languageEnglish
Article number9680
JournalAge
Volume36
Issue number4
DOIs
StatePublished - 1 Jan 2014

Fingerprint

Heart Arrest
Resuscitation
Wounds and Injuries
Brain
Survivors
Cause of Death
Oxidative Stress
Quality of Life
Neurons
Therapeutics
Research

Keywords

  • Caspases
  • Glutathione
  • Inflammation
  • Ischemia
  • Neurodegeneration
  • Oxidative Stress

Cite this

@article{db1d63f399db4a7084c4c4992cac1cff,
title = "Neuronal injury from cardiac arrest: aging years in minutes",
abstract = "Cardiac arrest is a leading cause of death and permanent disability. Most victims succumb to the oxidative and inflammatory damage sustained during cardiac arrest/resuscitation, but even survivors typically battle long-term neurocognitive impairment. Although extensive research has delineated the complex mechanisms that culminate in neuronal damage and death, no effective treatments have been developed to interrupt these mechanisms. Of importance, many of these injury cascades are also active in the aging brain, where neurons and other cells are under persistent oxidative and inflammatory stress which eventually damages or kills the cells. In light of these similarities, it is reasonable to propose that the brain essentially ages the equivalent of several years within the few minutes taken to resuscitate a patient from cardiac arrest. Accordingly, cardiac arrest-resuscitation models may afford an opportunity to study the deleterious mechanisms underlying the aging process, on an accelerated time course. The aging and resuscitation fields both stand to gain pivotal insights from one another regarding the mechanisms of injury sustained during resuscitation from cardiac arrest and during aging. This synergism between the two fields could be harnessed to foster development of treatments to not only save lives but also to enhance the quality of life for the elderly.",
keywords = "Caspases, Glutathione, Inflammation, Ischemia, Neurodegeneration, Oxidative Stress",
author = "Cherry, {Brandon H.} and Nathalie Sumien and Mallet, {Robert T.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/s11357-014-9680-x",
language = "English",
volume = "36",
journal = "Age",
issn = "0161-9152",
publisher = "Springer Netherlands",
number = "4",

}

Neuronal injury from cardiac arrest : aging years in minutes. / Cherry, Brandon H.; Sumien, Nathalie; Mallet, Robert T.

In: Age, Vol. 36, No. 4, 9680, 01.01.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neuronal injury from cardiac arrest

T2 - aging years in minutes

AU - Cherry, Brandon H.

AU - Sumien, Nathalie

AU - Mallet, Robert T.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Cardiac arrest is a leading cause of death and permanent disability. Most victims succumb to the oxidative and inflammatory damage sustained during cardiac arrest/resuscitation, but even survivors typically battle long-term neurocognitive impairment. Although extensive research has delineated the complex mechanisms that culminate in neuronal damage and death, no effective treatments have been developed to interrupt these mechanisms. Of importance, many of these injury cascades are also active in the aging brain, where neurons and other cells are under persistent oxidative and inflammatory stress which eventually damages or kills the cells. In light of these similarities, it is reasonable to propose that the brain essentially ages the equivalent of several years within the few minutes taken to resuscitate a patient from cardiac arrest. Accordingly, cardiac arrest-resuscitation models may afford an opportunity to study the deleterious mechanisms underlying the aging process, on an accelerated time course. The aging and resuscitation fields both stand to gain pivotal insights from one another regarding the mechanisms of injury sustained during resuscitation from cardiac arrest and during aging. This synergism between the two fields could be harnessed to foster development of treatments to not only save lives but also to enhance the quality of life for the elderly.

AB - Cardiac arrest is a leading cause of death and permanent disability. Most victims succumb to the oxidative and inflammatory damage sustained during cardiac arrest/resuscitation, but even survivors typically battle long-term neurocognitive impairment. Although extensive research has delineated the complex mechanisms that culminate in neuronal damage and death, no effective treatments have been developed to interrupt these mechanisms. Of importance, many of these injury cascades are also active in the aging brain, where neurons and other cells are under persistent oxidative and inflammatory stress which eventually damages or kills the cells. In light of these similarities, it is reasonable to propose that the brain essentially ages the equivalent of several years within the few minutes taken to resuscitate a patient from cardiac arrest. Accordingly, cardiac arrest-resuscitation models may afford an opportunity to study the deleterious mechanisms underlying the aging process, on an accelerated time course. The aging and resuscitation fields both stand to gain pivotal insights from one another regarding the mechanisms of injury sustained during resuscitation from cardiac arrest and during aging. This synergism between the two fields could be harnessed to foster development of treatments to not only save lives but also to enhance the quality of life for the elderly.

KW - Caspases

KW - Glutathione

KW - Inflammation

KW - Ischemia

KW - Neurodegeneration

KW - Oxidative Stress

UR - http://www.scopus.com/inward/record.url?scp=84905305023&partnerID=8YFLogxK

U2 - 10.1007/s11357-014-9680-x

DO - 10.1007/s11357-014-9680-x

M3 - Article

C2 - 25104136

AN - SCOPUS:84905305023

VL - 36

JO - Age

JF - Age

SN - 0161-9152

IS - 4

M1 - 9680

ER -