Neuroinflammatory responses from microglia recovered from HIV-1-infected and seronegative subjects

Anuja Ghorpade, Yury Persidsky, Susan Swindells, Kathleen Borgmann, Raisa Persidsky, Spring Holter, Robin Cotter, Howard E. Gendelman

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Microglial and macrophage infection and immune activation underlie the pathogenesis of HIV-1-associated dementia (HAD). To assess microglial function in HAD, we isolated cells from brain tissues recovered from an HIV-1-infected patient within 4 h of death. Brain tissue from seronegative patients served as controls. Regional neuropathology was correlated to microglial function. HIV-1-patient microglia formed multinucleated giant cells and produced progeny virions. These microglia secreted reduced basal and LPS-stimulated TNF-α levels compared to controls. Monocytes from seronegative donors paralleled these diminished immune responses following repeated LPS-activation. These results demonstrate changes in innate microglial function following viral infection or chronic immune activation.

Original languageEnglish
Pages (from-to)145-156
Number of pages12
JournalJournal of Neuroimmunology
Volume163
Issue number1-2
DOIs
StatePublished - 1 Jun 2005

Keywords

  • Chronic inflammation
  • HIV-1-associated dementia
  • Microglia activation
  • Rapid autopsy

Fingerprint Dive into the research topics of 'Neuroinflammatory responses from microglia recovered from HIV-1-infected and seronegative subjects'. Together they form a unique fingerprint.

  • Cite this

    Ghorpade, A., Persidsky, Y., Swindells, S., Borgmann, K., Persidsky, R., Holter, S., Cotter, R., & Gendelman, H. E. (2005). Neuroinflammatory responses from microglia recovered from HIV-1-infected and seronegative subjects. Journal of Neuroimmunology, 163(1-2), 145-156. https://doi.org/10.1016/j.jneuroim.2005.01.022