Neuroglobin expression in neurogenesis

Bryan Haines, Xiao Ou Mao, Lin Xie, Steve Spusta, Xianmin Zeng, Kunlin Jin, David A. Greenberg

Research output: Contribution to journalComment/debate

11 Scopus citations

Abstract

Neuroglobin is a hypoxia-inducible, neuroprotective protein related to myoglobin and hemoglobin, but little is known about its neurodevelopmental expression or function. To begin to explore these issues, we measured neuroglobin protein expression during neuronal differentiation of human embryonic stem cells in vitro and in the neurogenic subventricular zone of adult rats in vivo. Neuroglobin protein expression was barely detectable by western blotting in human embryonic stem cells, but was readily demonstrable in neural stem cells, and was further induced upon differentiation to neurons. In the adult subventricular zone, neuroglobin expression coincided with that of the neuronal lineage marker doublecortin, but not with vimentin or glial fibrillary acidic protein. These findings suggest that neuroglobin is expressed early in the course of neuronal differentiation and may, therefore, have a role in neurodevelopment.

Original languageEnglish
Pages (from-to)3-6
Number of pages4
JournalNeuroscience Letters
Volume549
DOIs
StatePublished - 9 Aug 2013

Keywords

  • Neurogenesis
  • Neuroglobin
  • Stem cell
  • Subventricular zone

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    Haines, B., Mao, X. O., Xie, L., Spusta, S., Zeng, X., Jin, K., & Greenberg, D. A. (2013). Neuroglobin expression in neurogenesis. Neuroscience Letters, 549, 3-6. https://doi.org/10.1016/j.neulet.2013.04.039