Neuroglobin expression in ischemic stroke

Kunlin Jin, Ying Mao, Xiao Mao, Lin Xie, David A. Greenberg

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Background and Purpose:We investigated whether neuroglobin, a neuronal protein that protects neurons from hypoxic-ischemic injury, is upregulated in ischemic stroke. Methods: Neuroglobin immunoreactivity was measured in brain tissue from control subjects and patients with ischemic stroke. Results-Neuroglobin was detected in several brain areas, and its expression was increased in the cortical peri-infarct region after stroke. Conclusions:s: Ischemic stroke increases expression of the neuroprotective protein neuroglobin, suggesting neuroglobin may represent a novel target for stroke therapy.

Original languageEnglish
Pages (from-to)557-559
Number of pages3
JournalStroke
Volume41
Issue number3
DOIs
StatePublished - Mar 2010

Keywords

  • Ischemia
  • Neuroglobin
  • Neuroprotection

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